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[studies on infection of helicobacter pylori and their subtypes caga+ and hspa+ in population living in the areas with high and low incidence of gastric cancer].to explore the difference in infection of helicobacter pylori (hp) and their subtypes caga+ and hspa+ in the residents living in the areas with high and low incidence of gastric cancer.199810322798
helicobacter-ápylori infection in asymptomatic hbv carriers, alcohol users and normal adult population in shandong province, china.the purpose of this study was to investigate the prevalence of helicobacter-ápylori (h.-ápylori) in asymptomatic hbv carriers (ascs), alcohol users and in the normal adult population in the littoral region of shandong, china.201121680277
randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions.randomized trials have yielded mixed results on the effects of treatment for helicobacter pylori and little information on the effects of vitamins or garlic supplements on precancerous gastric lesions. we conducted a randomized trial to test the effects of one-time h. pylori treatment and long-term vitamin or garlic supplements in reducing the prevalence of advanced precancerous gastric lesions.200616849680
h. pylori genotypes and cytokine gene polymorphisms influence the development of gastric intestinal metaplasia in a chinese population.cytokine gene polymorphisms and helicobacter pylori (hp) genotypes have been linked to gastric cancer development in western countries. we determined the role of host cytokine polymorphisms and bacterial virulent factors in the development of gastric intestinal metaplasia (im) in a chinese population with a high background gastric cancer incidence.200616635219
etiology and prevention of gastric cancer: a population study in a high risk area of china.a series of studies has been carried out in linqu county, shandong province, china, a high-risk area for gastric cancer, to investigate the risk factors associated with gastric cancer, precancerous lesions and the prevention of gastric cancer. our studies showed that sour pancakes (a popular local food), salted foods, cigarette smoking, and family history of gastric cancer were risk factors, whereas fresh vegetables, and intake of vitamin c and calcium were inversely associated with the risk of ...200516246221
efficacy of cranberry juice on helicobacter pylori infection: a double-blind, randomized placebo-controlled trial.helicobacter pylori infection is a major cause of peptic ulcer disease and gastric cancer. this study postulated that cranberry juice would be effective in the suppression of h. pylori in an endemically infected population at high risk for gastric cancer.200515810945
helicobacter pylori infection and gastric cancer: evidence from a retrospective cohort study and nested case-control study in china.to explore the association between helicobacter pylori (hp) infection and risk of gastric cancer in china.200212439934
helicobacter pylori prevalence and caga status among children in two counties of china with high and low risks of gastric cancer.background: studies in adult populations in selected countries with widely varying rates of gastric cancer have shown a weak correlation between gastric cancer mortality rates and the prevalence of caga+ strains of h. pylori. however, only limited data are available in ethnically homogenous populations with varying rates in the same region. methods; we compared the prevalence of h. pylori in general and of caga+ strains in particular among children in shandong province, china in areas at high (l ...200111709273
helicobacter pylori infection in rural china: exposure to domestic animals during childhood and adulthood.little is known about the mode of transmission of helicobacter pylori, one of the most common human bacterial infections. some domestic animals, including the cat, have been suggested as a reservoir of h. pylori disease, but the data have been inconsistent. this paper evaluates the role of exposure to pets and other domestic animals in the etiology of h. pylori in a rural area of china with a high prevalence of h. pylori infection. in this double-blind, population-based, cross-sectional investig ...200111669227
an intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and s-allyl cysteine levels, and toxicity.gastric cancer is the second most frequent cause of death from cancer in the world and the leading cause of death from cancer in china. in september 1995, we launched a randomized multi-intervention trial to inhibit the progression of precancerous gastric lesions in linqu county, shandong province, an area of china with one of the world's highest rates of gastric cancer. treatment compliance was measured by pill counts and quarterly serum concentrations of vitamin c, vitamin e and s-allyl cystei ...200111432713
helicobacter pylori infection, garlic intake and precancerous lesions in a chinese population at low risk of gastric cancer.cangshan county of shandong province has one of the lowest rates of gastric cancer (gc) in china. while intestinal metaplasia (im) and dysplasia (dys) are less common in cangshan than in areas of shandong at high risk of gc, these precursor lesions nevertheless affect about 20% of adults age > or = 55.199810024185
factorial trial of three interventions to reduce the progression of precancerous gastric lesions in shandong, china: design issues and initial data.in the fall of 1995, 3411 subjects in 13 rural villages in linqu county, shandong province, china, began participating in a blinded, randomized 23 factorial trial to determine whether interventions can reduce the prevalence of dysplasia and other precancerous gastric lesions. one intervention is treatment for infection by helicobacter pylori with amoxicillin and omeprazole. a second is dietary supplementation with capsules containing vitamin c, vitamin e, and selenium. a third is dietary supplem ...19989683311
recent changes in the prevalence of helicobacter pylori infection among children and adults in high- or low-incidence regions of gastric cancer in china.the prevalence of helicobacter pylori (h. pylori) infection varies by geographic locations. studies indicate that the infection rate of h. pylori was previously high in china but that rates had been declining worldwide over recent decades. the aims of our study were: (1) to determine the current prevalence of h. pylori infection among children and adults residing in areas with high (muping county, shandong) and low (yanqing county, beijing) incidences of gastric cancer in china, and (2) to compa ...200919781321
a randomized factorial study of the effects of long-term garlic and micronutrient supplementation and of 2-wk antibiotic treatment for helicobacter pylori infection on serum cholesterol and lipoproteins.little is known about the long-term effects of garlic or micronutrient supplementation on total, hdl, and ldl cholesterol in disease-free persons.200617023720
a factorial trial including garlic supplements assesses effect in reducing precancerous gastric lesions.the shandong intervention trial was a factorial, double-blind, placebo-controlled trial to determine whether any of 3 interventions, alone or in combination, could reduce the prevalence of precancerous gastric lesions in linqu county, shandong province, china, a region with high gastric cancer mortality rates and a prevalence in adults of helicobacter pylori of approximately 67%. the 3 interventions were one-time treatment with amoxicillin and omeprazole for helicobacter pylori infection, and lo ...200616484571
the changing trends of the incidence of gastric cancer after helicobacter pylori eradication in shandong area. 200516045599
etiology and prevention of gastric cancer in linqu county, shandong province, china. 200516045598
[studies of the relationship of hla polymorphisms and the infection of h. pylori in the population of linqu in shandong province].in order to analyze the relationship of hla polymorphisms and the infection of h. pylori in the population of linqu county in shandong province, polymerase chain reaction with sequence-specific primers(pcr-ssp) was used to determine the alleles of hla type i and ii in 90 hp-positive persons and 49 hp-negative controls. the results showed that among the 68 alleles of hla type i ,4 alleles were found significantly different between hp-positive and hp-negative population,while no significant differ ...200415662734
helicobacter pylori infection in rural china: demographic, lifestyle and environmental factors.although helicobacter pylori is one of the most common human bacterial infections worldwide, its mode of transmission is unclear.200212055167
probability of helicobacter pylori infection based on igg levels and other covariates using a mixture model.to use igg antibody measurements to detect infection with helicobacter pylori (h. pylori). one typically defines a cut-off value based on samples of persons presumed to be infected or uninfected. when there are no good 'gold standard' tests to determine infection status, or when laboratory conditions vary, it is useful to have a method based on the igg measurements themselves to determine infection status.200011142602
[preliminary investigation of helicobacter pylori infection in linqu county of shandong province].a preliminary epidemiological investigation of helicobacter pylori (hp) infection was performed with 13c-urea breathing test for 218 residents at the age from 40 to 69 years in a high risk area of gatric cancer, linqu county of shandong province. our results show an overall hp infection rate of 71.10%, or 69.49% for men and 73.00% for women. the hp infection rate in the group of serious chronic atrophic gastritis was significantly higher than that of mild chronic atrophic gatritis (p < 0.05). th ...19969208603
[epidemiology of helicobacter pylori infection in shandong and beijing areas.].to study the current prevalence and recent epidemiological changes of helicobacter pylori (h. pylori) infection among children and adults residing in regions with high (muping, shandong) and low (yanqing, beijing) incidence of gastric cancer in china.200920193516
a placebo-controlled trial of 10-day bismuth-based quadruple therapy to eradicate helicobacter pylori infection; a pilot study for the large linqu county trial.to explore a low-cost and highly-effective therapy for eradication of helicobacter pylori (h. pylori), a placebo-controlled trial of quadruple therapy was conducted in a population at high risk of gastric cancer in linqu county of shandong province, china.201019996977
polymorphism of cypia1 and gstm1 genes associated with susceptibility of gastric cancer in shandong province of china.to explore whether polymorphisms of the cypia1 and gstm1 genes are associated with susceptibility of stomach cancer.200516270381
serum antibodies to helicobacter pylori and the caga antigen do not explain differences in the prevalence of precancerous gastric lesions in two chinese populations with contrasting gastric cancer rates.incidence and mortality rates for gastric cancer in rural people's republic of china differ greatly over short distances. in shandong province, we studied asymptomatic adult subjects from bei duan village (n = 196) in linqu county (a high-risk area for gastric cancer) and from shi huang village (n = 192) in cangshan county (a low-risk area for gastric cancer). the prevalence of advanced precancerous gastric lesions (apgl) was assessed by microscopic examination of endoscopic stomach biopsies. el ...200212376512
[the correlation between polymorphisms of toll-like receptor 2 and toll-like receptor 9 and susceptibility to gastric cancer].to explore the relationship between the polymorphisms of toll-like receptor 2 (tlr2) and tlr9 and the susceptibility to gastric cancer.201122041559
[the associations of serum gastrin level with helicobacter pylori infection].to investigate the associations of serum gastrin-17 (g-17) concentration with helicobacter pylori (hp) infection.200717767867
Genetic variants of toll-like receptor 2 and 5, helicobacter pylori infection, and risk of gastric cancer and its precursors in a chinese population.Genetic polymorphisms of Toll-like receptors (TLR) may influence the outcome of Helicobacter pylori infection and play important roles in gastric carcinogenesis. To screen the genetic variants of TLR2 and TLR5, and evaluate their associations with gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shandong Province, China.201121994405
fifteen-year effects of helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality.in the shandong intervention trial, 2 weeks of antibiotic treatment for helicobacter pylori reduced the prevalence of precancerous gastric lesions, whereas 7.3 years of oral supplementation with garlic extract and oil (garlic treatment) or vitamin c, vitamin e, and selenium (vitamin treatment) did not. here we report 14.7-year follow-up for gastric cancer incidence and cause-specific mortality among 3365 randomly assigned subjects in this masked factorial placebo-controlled trial. conditional lo ...201222271764
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