Publications

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time trends in peptic ulcer, erosive reflux oesophagitis, gastric and oesophageal cancers in a multiracial asian population.dramatic changes in the prevalence and pattern of gastrointestinal disease has taken place in asia in recent years.200919183160
helicobacter pylori: prevalence, clinical and endoscopic findings in children who underwnet upper endoscopy for abdominal ailments.a total of 97 children aged 1 month to 16 years (mean 6.6 years) had upper endoscopies performed in paediatric institute, kuala lumpur hospital between january 1997 and december 1999 for various gastrointestinal symptoms. of these 70 children were tested for helicobacter pylori. the four most common indications for upper endoscopy were recurrent abdominal pain, upper gastrointestinal bleeding, epigastric pain and vomiting. the overall prevalence of this infection in this heterogenous group of sy ...200112014759
functional and molecular surveillance of helicobacter pylori antibiotic resistance in kuala lumpur.helicobacter pylori is the etiological agent for diseases ranging from chronic gastritis and peptic ulcer disease to gastric adenocarcinoma and primary gastric b-cell lymphoma. emergence of resistance to antibiotics possesses a challenge to the effort to eradicate h. pylori using conventional antibiotic-based therapies. the molecular mechanisms that contribute to the resistance of these strains have yet to be identified and are important for understanding the evolutional pattern and selective pr ...201425003707
comparative efficacy sensitivity and specificity of the tests used for the diagnosis of helicobacter pylori.abstract: a total number of 157 samples were examined by 4 different tests-in-house rapid urease (irut), culture, histopathology and immunochromatography (immuno cardstat) for the detection of helicobacter pylori from the patients reported to hospital kuala lumpur, malaysia during 2007 to 2008. out of the samples examined 47 (29.9%) were positive for h. pylori by the tests used in the laboratory. efficacy of detection of the bacteria by the tests- in-house rapid urease, culture, histopathology a ...201021313878
gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial asian population: a prospective, endoscopy based study.to determine the prevalence of and risk factors for gastro-oesophageal reflux disease (gord), reflux oesophagitis and non-erosive reflux disease (nerd) amongst malaysian patients undergoing upper gastrointestinal endoscopic examination.200415097043
the racial cohort phenomenon: seroepidemiology of helicobacter pylori infection in a multiracial south-east asian country.malaysia is a multiracial country where three major asian races live together: malay, chinese and indian. in addition, there are a number of native or indigenous races, particularly in east malaysia. differences in prevalence of gastric diseases between races have been noted, particularly with respect to peptic ulcer disease and gastric cancer. the aim of this study is to determine the prevalence rates and risk factors for helicobacter pylori infection among various races in malaysia.200111246618
gastro-oesophageal reflux is more prevalent in western dyspeptics: a prospective comparison of british and south-east asian patients with dyspepsia.there is a paucity of data directly comparing dyspepsia in western and eastern populations.200515948816
prevalence of and risk factors for helicobacter pylori infection in a multi-racial dyspeptic malaysian population undergoing endoscopy.the aim of the present study was to determine the risk factors for helicobacter pylori in a dyspeptic malaysian population. a cross-sectional survey of 1060 consecutive patients presenting with dyspepsia at the endoscopic unit, university hospital, kuala lumpur, malaysia from january 1994 to july 1995 was undertaken. all patients answered a detailed questionnaire and underwent endoscopy, with two antral biopsies taken for diagnosis of h. pylori using a rapid urease test. an overall h. pylori pre ...19979195409
distribution of helicobacter pylori caga, cage and vaca in different ethnic groups in kuala lumpur, malaysia.there is a geographic variation in helicobacter pylori (hp) genotypes and virulence factors. cytotoxin associated genes a (caga) and e (cage), and certain vacuolating cytotoxin (vaca) genotypes are associated with peptic ulcer disease (pud). there is also a different prevalence of pud among different ethnic groups in malaysia. the present study compared the distribution of vaca alleles and caga and cage status in three ethnic groups residing in kuala lumpur, malaysia, and their association with ...200515836708
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