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seroepidemiologic study of helicobacter pylori infection in children in taipei city.to study the epidemiology of helicobacter pylori (h. pylori) infection in children, the presence of the igg antibody against h. pylori was evaluated by enzyme-linked immunosorbent assay (elisa) method in unselected children in taipei city. serum samples were collected there from 428 apparently healthy children under 12 years of age. the overall prevalence of h. pylori infection was 8.4%. a low prevalence was found in the groups 1-3 years old (0.9%) and 3-6 years old (3.7%). the prevalence rate i ...19957572166
serum levels of pepsinogen i in healthy volunteers and patients with gastric ulcers and gastric carcinoma in taiwan.in order to investigate the clinical usefulness of human pepsinogen i (pgi) as a noninvasive diagnostic tool for gastric lesions, 92 healthy volunteers, 87 patients with a gastric ulcer and 94 patients with gastric carcinoma, verified by histologic examinations, were enrolled. the serum level of pgi in each patient was measured by radioimmunoassay. mean serum pgi levels were 95.4 +/- 39.4 ng/ml in patients with gastric ulcers, 77.6 +/- 29.3 ng/ml in healthy volunteers, and 52.1 +/- 26.5 ng/ml in ...19937904845
genetic analysis and clinical evaluation of vacuolating cytotoxin gene a and cytotoxin-associated gene a in taiwanese helicobacter pylori isolates from peptic ulcer patients.the aims of this study were to investigate the cytotoxin-associated gene a (caga) and vacuolating cytotoxin gene a (vaca) subtype in taiwanese h. pylori isolates from patients with gastroduodenal diseases and to assess the relationship between genotypes of isolates and clinical features. the vaca s1a allele was found in all isolates and vaca m1 allele was found in 15% of isolates. the caga gene was found in 82.5% of isolates. the vaca s1a/m2 strains had a significantly higher prevalence rate tha ...200010716078
helicobacter pylori infection and gastric emptying in cirrhotic patients with symptoms of dyspepsia.chronic gastric helicobacter pylori infection is common in patients with dyspeptic symptoms. the effect of h. pylori infection on gastric emptying, in cirrhotic patients with dyspeptic symptoms, has never been studied. therefore, we investigated the incidence of h. pylori infection and its relationship with gastric emptying in cirrhotic patients with dyspepsia.199910626179
heterogeneous helicobacter pylori isolates from h. pylori-infected couples in taiwan.helicobacter pylori strain diversity was investigated in 55 h. pylori seropositive couples in taiwan in biopsy samples from the antrum and corpus. two dna typing methods were used to characterize 90 isolates from 25 couples. in only 1 of the 25 couples was the same strain colonized from both partners. comparison of isolates from 2 sites in each of 40 patients showed that 9 pairs were distinct but might be related. peptic ulcer occurred in 77.8% of these 9 patients compared with 29% of 31 patient ...199910558972
smoking and male gender rather than caga protein are associated with increased risk for duodenal ulcer in helicobacter pylori-infected patients in taiwan.the aim of this study was to examine the seroprevalence of antibody to caga antigen, as well as other major h. pylori antigens by western blot in h. pylori-infected subjects with endoscopically normal mucosa (n = 54) and duodenal ulcer (n = 51). the role of the host and environmental factors was also evaluated. there was no significant difference in the prevalence of antibodies against the major h. pylori antigens between the two groups. a high prevalence of antibody to caga was detected in pati ...199910548360
lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of epstein-barr virus infection.to evaluate the clinicopathological features of lymphoepithelioma-like carcinoma of stomach in taiwan.199910370694
development of helicobacter pylori infection model in balb/c mice with domestic caga-positive and -negative strains in taiwan.we aimed to develop an h. pylori-infected mouse model using clinically stored strains in taiwan and to test whether development of h. pylori infection in an in vivo animal model is related to the status of the caga gene. a total of 100 male balb/c mice, 6-8 weeks old, including 80 in the experimental group and 20 in the control group, were used. two clinically stored h. pylori isolates, a caga-positive and a caga-negative strain, were selected to induce the h. pylori infection in half (n = 40) o ...199910235589
association between seropositivity of antibodies against hepatitis a virus and helicobacter pylori.helicobacter pylori and hepatitis a virus (hav) are documented to share common transmission routes including fecal-oral. this study examined the association between seropositivity of antibodies against h. pylori (anti-hp) and hav (anti-hav) via a community-based survey of 40 randomly selected kindergartens in 10 urban and 10 rural areas. serum samples from 2,047 healthy preschool children and 104 teachers were screened for anti-hp by enzyme-linked immunosorbent assay, and for anti-hav by micropa ...200011388513
helicobacter pylori infection in hemodialysis patients. 200111817316
helicobacter pylori in gastric biopsies of taiwanese patients with gastroduodenal diseases.this study was designed to study the in vivo prevalence and the heterogeneity of h. pylori in patients with gastroduodenal diseases in central taiwan. h. pylori infection was detected in 74.1% (575/776) of the symptomatic population studied. the prevalence of h. pylori infection increased from 11.1% in those between the ages of one to 20, to 82.9% in those between the ages of 41 and 50, and to 84% in those between the ages of 51 and 60. there was no significant difference in the prevalence of h. ...199810211428
high frequency of cytotoxin-associated gene a in helicobacter pylori isolated from asymptomatic subjects and peptic ulcer patients in taiwan.cytotoxin-associated gene a (caga), expressed in about 60% of h. pylori isolates in western countries, may play a role in the pathogenesis of peptic ulcer. in this study, we determined the prevalence and significance of the h. pylori caga gene and protein expression in taiwan. genomic dna from antrum biopsies and h. pylori isolates were analyzed for caga using polymerase chain reaction, southern hybridization, or colony hybridization. caga seropositivity was analyzed using helico blots. in addit ...19989706771
quantification of helicobacter pylori infection: simple and rapid 13c-urea breath test in taiwan.the 13c-urea breath test (13c-ubt) is a non-invasive method for detecting helicobacter pylori. this study was performed to determine the cutoff value and evaluate the sensitivity and specificity of 13c-ubt in taiwan. 13c-urea (100 mg of 99% 13c-labeled urea) was dissolved in 50 ml sterile water for the test. the test meal for delaying gastric emptying was 100 ml fresh milk. patients fasted for at least 6h. a baseline breath sample was collected 5 min after they had the test meal. two other sampl ...19989658310
distinct clinicopathologic characteristics of diffuse- and intestinal-type gastric cancer in taiwan.the clinicopathologic features of 221 patients with intestinal-type (it) gastric cancer were compared retrospectively with those of 290 diffuse type (dt). intestinal type was characterized by an older mean age (65.0 +/- 10.8 years vs. 56.2 +/- 13 years), a higher male-female ratio (2.56 vs. 1.06), predominance of blood group o (46.2% vs. 31.1%), and frequent habitual smoking (50.7% vs. 31.4%) and drinking (28.5% vs. 17.6%) than did dt. in contrast, dt had a higher frequency of positive history o ...19979451680
genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in helicobacter pylori strains isolated from taiwanese patients.two virulence factors encoded by the cytotoxin-associated (caga) gene and the vacuolating toxin (vaca) gene of helicobacter pylori are known to be associated with gastroduodenal pathologic conditions. in this report, nucleotide sequence of caga and vaca and the serum antibody response to the caga antigen in h. pylori isolates from taiwanese patients were studied.19979260797
increased prevalence of helicobacter pylori infection among patients affected with intestinal-type gastric cancer at non-cardiac locations.previous data on the association of helicobacter pylori infection with gastric cancer by demographic or histological features are inconsistent due to a univariate analysis of limited case numbers. the aim of the present study was to determine such an association by the use of a large series of patients and multiple variables analysis. the serum igg antibodies against h. pylori were measured in 397 patients with histologically verified gastric cancer. a multiple logistic regression analysis was u ...19979195398
seroprevalences of hepatitis b and c viruses and helicobacter pylori infection in a small, isolated population at high risk of gastric and liver cancer.the objective of this study was to examine the seroprevalences of chronic infection with hepatitis b and c viruses and helicobacter pylori in matzu, a group of small islets with 5,566 civilian residents who have extremely high mortality from cancers of the stomach and liver. the standardized mortality ratios (smr) of all cancer sites combined, liver cancer and stomach cancer in 1984-1993 were calculated using the general population in taiwan as the referent (smr = 100). the smrs (95% confidence ...19979180145
high seroprevalence of igg against helicobacter pylori among endoscopists in taiwan.a prospective survey to investigate the seroprevalence of igg against helicobacter pylori among endoscopists in taiwan was conducted by analyzing blood samples of 70 study subjects and 64 nonendoscopist physicians with quantitative elisa. personal information and the practices of infection control related to gastroscopy examination were obtained by a self-administered questionnaire. significant differences were detected in the igg prevalence between study and control subjects (80.0% vs 51.6%; p ...19968769281
helicobacter pylori infection in a randomly selected population, healthy volunteers, and patients with gastric ulcer and gastric adenocarcinoma. a seroprevalence study in taiwan.to investigate the association of helicobacter pylori and gastric ulcer and adenocarcinoma, igg antibodies against h. pylori were examined in 823 randomly selected subjects, 92 healthy volunteers, 117 patients with gastric ulcer, and 148 with gastric adenocarcinomas in taiwan, where the prevalence of gastric adenocarcinoma is high. the seropositivity of this population in taiwan was 54.4%. gastric ulcer patients had a higher seropositivity (83.8%) than healthy volunteers (62.0%) and gastric aden ...19938303209
helicobacter pylori infection in early and advanced gastric adenocarcinoma: a seroprevalence study in 143 taiwanese patients.the association between gastric adenocarcinoma and helicobacter pylori infection remains controversial. a seroprevalence study of helicobacter pylori infection in 143 patients with gastric adenocarcinoma and a control group of 823 subjects randomly selected from four areas in taiwan, was carried out to elucidate the association. the overall seropositivity of helicobacter pylori in gastric adenocarcinoma patients (62.9%) was higher than in controls (54.4%), but the difference was not statisticall ...19938119647
time-dependent amplified pharmacokinetic and pharmacodynamic responses of rabeprazole in cytochrome p450 2c19 poor metabolizers.to determine the pharmacokinetic and pharmacodynamic rationale for the optimum regimen of rabeprazole in the treatment of helicobacter pylori infection in patients who are cytochrome p450 (cyp) 2c19 poor metabolizers or extensive metabolizers.200312820812
seroprevalence and associated risk factors of helicobacter pylori infection in taiwan.in order to estimate the seroprevalence and explore multiple risk factors associated with helicobacter pylori infection among residents in taiwan, a total of 823 subjects randomly selected from one metropolitan precinct and three townships were studied. serum samples were tested for igg antibodies against h. pylori by enzyme-linked immunosorbent assay using commercial kits. the overall seropositive rate was 54.4% with no gender difference (53.7% for males and 55.2% for females). there was a sign ...19948067711
seroprevalence of helicobacter pylori in school-aged chinese in taipei city and relationship between abo blood groups.to explore the seropositive rate of antibodies against h. pylori (anti-hp) in taipei city and to compare the relationship of abo blood groups and h. pylori infection.200312918114
seroprevalence study of helicobacter pylori infection in patients with gastroduodenal diseases.to investigate helicobacter pylori (h. pylori) infection in subjects with and without gastroduodenal diseases in taiwan, igg antibodies to h. pylori were examined in 136 healthy volunteers, 101 patients with non-ulcer dyspepsia, 122 gastric ulcers, 119 duodenal ulcers, and 161 gastric adenocarcinomas. the seropositivity was highest in duodenal ulcers (87.4%) (p < 0.001, as compared to healthy volunteers), followed by gastric ulcers (76.2%) (p < 0.01, as compared to healthy volunteers), but simil ...19947912582
ecological study of association between helicobacter pylori infection and gastric cancer in taiwan.the association between helicobacter pylori infection and gastric cancer remains controversial. a community-based serosurvey was carried out in taiwan to investigate the association. serum igg antibodies against helicobacter pylori were examined in 728 subjects randomly selected from three townships with different gastric cancer mortality rates. the overall seropositivity of helicobacter pylori was 54.7% (398/728) with no gender difference (males: 54.5%; females: 54.8%). the seroprevalence of he ...19957851203
t(11;18)(q21;q21) in gastric malt lymphoma and diffuse large b-cell lymphoma of chinese patients.t(11;18)(q21;q21) occurs at variable frequencies in mucosa-associated lymphoid tissue (malt) lymphomas of different sites. in gastric malt lymphoma, it occurs in 30% cases and the translocation positive tumours are frequently at advanced stages and do not respond to helicobacter pylori eradication. intriguingly, t(11;18)(q21;q21) has been observed only rarely in mucosal diffuse large b-cell lymphomas (dlbcl), despite that at least a proportion of these tumours are believed to be the result of tr ...200314502259
helicobacter pylori caga, icea and vaca status in taiwanese patients with peptic ulcer and gastritis.helicobacter pylori causes chronic gastritis, peptic ulcer, gastric cancer and mucosa-associated lymphoid tissue (malt) lymphoma. different genotypes of h. pylori are confirmed from diverse geographical areas. its association with clinical diseases remains controversial. the aim of the present study was to investigate the h. pylori vacuolating cytotoxin (vaca) alleles, cytotoxin-associated gene (caga) and icea, in patients with peptic ulcer and gastritis.200314535980
[gastric cancer in taiwan].the study of gastric cancer is important in clinical medicine as well as in public health. environmental factors play an important role in gastric carcinogenesis and thus primary prevention is feasible after improvement of these factors. the 5-year survival rate of resected early gastric cancer is over 90% and this provides an excellent paradigm for secondary prevention. though its mortality rate has declined since 1970, gastric cancer remains common and carries a high mortality in taiwan where ...19947719165
epstein-barr virus-associated gastric carcinomas: relation to h. pylori infection and genetic alterations.the association of epstein-barr virus (ebv) and gastric carcinomas (gcs) has been shown to vary among different populations and certain histological subtypes. few studies have addressed the status of helicobacter pylori infection and genetic alterations in these ebv-positive or -negative gcs.200010833477
seroepidemiology of helicobacter pylori among adolescents in taiwan.helicobacter pylori has been documented to be associated with chronic type b gastritis, peptic ulcer and gastric cancer. in order to examine the seroprevalence and risk factors for helicobacter pylori infection in taiwan, a total of 871 adolescents were selected randomly from junior high school children in 20 study precincts and townships. serum samples collected were tested for igg antibodies against helicobacter pylori by enzyme-linked immunosorbent assay using commercial kits. the overall ser ...199610592783
helicobacter pylori and bleeding peptic ulcer: do we really need a gold standard? 200010882990
triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of helicobacter pylori in duodenal ulcer patients in asia and africa.studies assessing the efficacy of triple therapy containing clarithromycin and amoxicillin for the eradication of helicobacter pylori infection and healing of duodenal ulcers in asian and african countries are limited.200011069326
stable seroprevalence of helicobacter pylori infection in children during 1989-1999 in taipei, taiwan.helicobacter pylori (h. pylori) is thought to be acquired in childhood. the present study aimed to examine the changing seroepidemiology of h. pylori in children in the same area of taipei city during 1989-1999, and to try to elucidate the possible transmission route of h. pylori in children by comparing hepatitis a virus (hav) seroprevalence in taipei during the same decade.200415151548
seroepidemiology of helicobacter pylori infection among preschool children in taiwan.helicobacter pylori is associated with chronic antral gastritis that is related to duodenal ulcer, gastric ulcer, and probably gastric adenocarcinoma. infection with h. pylori during childhood is considered an important risk factor for gastric carcinoma in adult life. to examine the epidemiologic characteristics of h. pylori infection among preschool children in central taiwan, a community-based survey was carried out in 54 kindergartens in 10 urban townships, 10 metropolitan precincts, and 2 ab ...199910548288
high seroprevalence of igg against helicobacter pylori among endoscopists in taiwan. 19979378231
a novel tree-structured analysis for non-invasive diagnosis of gastric adenocarcinoma.non-invasive diagnosis of gastric adenocarcinoma (gac) is usually difficult due to the low sensitivity and specificity of serologic markers,including pepsinogens and gastrin. for the improvement of the diagnostic values of these markers, a "recursive partitioning and amalgamation" algorithm was employed to construct a decision protocol. a total of 636 subjects including 161 healthy subjects, 163 patients with gac, 196 with gastric ulcer and 116 with duodenal ulcer were enrolled. serum levels of ...19958669856
the rdxa gene plays a more major role than frxa gene mutation in high-level metronidazole resistance of helicobacter pylori in taiwan.metronidazole-resistant h. pylori associating with mutations of rdxa or frxa is still a debated topic. this study investigates whether rdxa and frxa mutations of h. pylori accounted for the high mic value (>/= 64 micro g/ml) of metronidazole (mtz).200415361078
the interleukin-1 rn polymorphism and helicobacter pylori infection in the development of duodenal ulcer.the host genetic factors that determine the clinical outcomes for helicobacter pylori-infected individuals remain unclear.200415610073
screening of anti-helicobacter pylori herbs deriving from taiwanese folk medicinal plants.in this study, extracts from 50 taiwanese folk medicinal plants were examined and screened for anti-helicobacter pylori activity. ninety-five percent ethanol was used for herbal extraction. paederia scandens (lour.) merr. (psm), plumbago zeylanica l. (pzl), anisomeles indica (l.) o. kuntze (aiok), bombax malabaricum dc. (bmdc) and alpinia speciosa (j. c. wendl.) k. schum. (asks) and bombax malabaricum dc. (bmdc) all demonstrated strong anti-h. pylori activities. the minimum inhibitory concentrat ...200515681161
a nested case-control study on the association between helicobacter pylori infection and gastric cancer risk in a cohort of 9775 men in taiwan.a nested case-control study was carried out to investigate the association between helicobacter pylori infection and gastric cancer risk in taiwan. a total of 29 patients newly affected with gastric cancer and 220 healthy controls matched with cases on age, sex and residence were selected from a cohort of 9,775 men recruited from 1984 through 1986. frozen serum samples collected at recruitment examination were tested for igg antibodies against helicobacter pylori by an enzyme-linked immunosorben ...19957763044
serologic response to lower-molecular-weight proteins of h. pylori is related to clinical outcome of h. pylori infection in taiwan.the study aimed to examine the serum serological response among h. pylori-infected patients with various upper gastrointestinal diagnoses; to ascertain whether it could be predictive to the diagnostic outcome of dyspepsia. one hundred seventy h. pylori-infected patients with dyspeptic symptoms but without previous treatment were enrolled, including those with duodenal ulcer disease (n = 47), gastric ulcer (n = 23), nonulcer dyspepsia (n = 60), gastric cancer (n = 34), and maltoma (n = 6). sera f ...200010759250
correlation between helicobacter pylori infection and gastrointestinal symptoms in pregnancy.nausea, vomiting, and other dyspeptic symptoms are common in pregnancy. this hospital-based, cross-sectional study was designed to determine the role of helicobacter pylori infection in gastrointestinal (gi) symptoms during pregnancy. standardized verbal scales were used to evaluate the frequency and severity of gi symptoms in 54 women whose pregnancies were in the first 16 gestational weeks. h. pylori infection was defined as a positive serum immunoglobulin g result on an immunochromatographic ...200011183452
primary resistance to antibiotics and its clinical impact on the efficacy of helicobacter pylori lansoprazole-based triple therapies.to evaluate helicobacter pylori primary resistance and its clinical impact on the efficacy of two lansoprazole-based eradication triple therapies.200211860412
association of hla-dqb1*0301 and hla-dqb1*0602 with different subtypes of gastric cancer in taiwan.gastric cancer (gc) is a heterogeneous disorder with multifactorial etiologies. genetic predisposition, environmental factors, and helicobacter pylori infection are thought to interact in the manifestation of gc. particular human leukocyte antigen (hla) alleles play a pivotal role in cellular immunity and may be an important genetically determined host trait. to elucidate the association between the genotype of hla class ii genes and the clinical phenotype of gc, polymorphisms of hla-drb1 and hl ...200211985790
clinical relevance of the vaca, icea, caga, and flaa genes of helicobacter pylori strains isolated in eastern taiwan.the genotypes of helicobacter pylori flaa, caga, vaca, and icea were determined for dna isolated from patients with chronic gastritis or peptic ulcer in eastern taiwan. the vaca gene encoding the s1a subtype was found to predominate in peptic ulcer patients, and the icea1 genotype was associated with chronic gastritis. caga and flaa genes were not found to be associated with these types of disease.200515956417
risk factors for intestinal metaplasia in adult residents of matzu: a cross-sectional study.people living on matzu, a group of small islets, have the highest mortality rate from gastric cancer (gc) in taiwan. intestinal metaplasia (im) is a precursor lesion of gc. we therefore conducted a gastroscopic screening program in this district to evaluate the risk factors associated with im.200212632816
helicobacter pylori and hepatitis a virus infection in school-aged children on two isolated neighborhood islands in taiwan.the transmission routes of helicobacter pylori and hepatitis a virus (hav) infections have been extensively discussed in previous literature. however, whether h. pylori and hav shared the same transmission pattern or not remains unclear. lower socioeconomic status was recognized as a consistent risk factor to both infections. however, whether fecal-oral transmission was a risk factor to both infections is still under debate.200312752727
relationship between helicobacter pylori infection and erosive gastroesophageal reflux disease.the role of helicobacter pylori in the pathogenesis of gastroesophageal reflux disease remains controversial. the aims of the study were to assess the factors that influence the severity of erosive esophagitis in taiwanese and to determine the prevalence of h. pylori infection in symptomatic patents.200415124045
using enzyme immunoassay to detect helicobacter pylori stool antigen for investigating the prevalence of helicobacter pylori infection in children and adolescents in changhua.to investigate the prevalence of helicobacter pylori (h. pylori) infection in adolescents and children in changhua and to compare the differences between urban and rural areas, we used enzyme immunoassay to detect h. pylori stool antigen for feco-prevalence study. in addition, a questionnaire was designed to obtain demographic and clinical information. children and adolescents under 18 years of age living in changhua city and yung-chin village were divided into 6 groups respectively, ie. 0-3, 3- ...200212148962
lack of evidence for fecal-oral transmission of helicobacter pylori infection in taiwanese.helicobacter pylori infection is primarily acquired in early childhood and its transmission routes are debated. the aims of this study were to determine the seroprevalence of anti-h. pylori immunoglobulin g (igg) in taiwanese and to investigate whether a common mode of transmission could be shared between h. pylori and hepatitis a virus (hav).200312923589
influences of lifestyle habits and p53 codon 72 and p21 codon 31 polymorphisms on gastric cancer risk in taiwan.influences of lifestyle habits and p53 codon 72 and p21 codon 31 polymorphisms on the risk for developing primary gastric cancer were examined in 89 gastric adenocarcinoma cases (51 males, 38 females) and 192 controls (106 males, 86 females) in a hospital-based, case-control study in taiwan. in the final regression model, helicobacter pylori infection and substance use (cigarette smoking, areca chewing) were significant predictors of risk for developing gastric cancer. compared with subjects neg ...200415036662
interleukin-10 genotypes associate with the risk of gastric carcinoma in taiwanese chinese.the association of cytokine genotypes with gastric carcinoma (gc) may be influenced by environmental factors and varies among different populations. few studies have addressed the impact of different cytokine genotypes on the development and progression of gc. we analyzed 11 functional polymorphisms in tumor necrosis factor-alpha (tnf-alpha), interleukin (il)-1, il-4 and il-10 genes in 220 taiwanese chinese with gc and in 230 healthy controls. the risk of genotypes was adjusted with confounding ...200312594817
lower prevalence of helicobacter pylori infection with vacas1a, caga-positive, and baba2-positive genotype in erosive reflux esophagitis disease.increased prevalence of esophagitis has been recognized in the west. helicobacter pylori infection, particularly virulent strains, is proposed as a protective factor against the development of gastroesophageal reflux disease. to evaluate the relationship of reflux esophagitis with virulent h. pylori infection, we studied the prevalence of reflux esophagitis among h. pylori-infected and -uninfected patients and the genotype of isolates in taiwan.200516302983
trends in prescribing proton pump inhibitors in taiwan: 1997 - 2000.the prescribing of proton pump inhibitors (ppis) had increased greatly in recent years worldwide. aim of our study was to analyze the utilization patterns of ppis within the national health insurance program in taiwan from 1997 - 2000.200312776811
host gastric lewis expression determines the bacterial density of helicobacter pylori in baba2 genopositive infection.we tested if host gastric lewis antigens and the baba2 genotype of helicobacter pylori correlated with clinicohistological outcome.200312801945
clinical characteristics and endoscopic findings associated with blastocystis hominis in healthy adults.ninety-nine individuals with stools positive for blastocystis hominis but negative for other parasites were identified from medical records of healthy adults who had received a physical examination at taipei veterans general hospital from november 2000 to october 2002. the medical records of these 99 positive cases and 193 randomly selected controls, matched for age, sex, and date of examination, were retrospectively reviewed. the pathogenicity of b. hominis could not be demonstrated due to a la ...200313677378
genotypes of helicobacter pylori in patients with peptic ulcer bleeding.helicobacter pylori causes chronic gastritis, peptic ulcer, gastric cancer and malt-lymphoma. different genotypes of helicobacter pylori are confirmed from diverse geographic areas. its association with bleeding peptic ulcer remains controversial. the aim of this study was to investigate the helicobacter pylori vaca alleles, caga and icea in patients with bleeding peptic ulcer.200414966926
silent peptic ulcer disease: frequency, factors leading to "silence," and implications regarding the pathogenesis of visceral symptoms.peptic ulcer disease may occur in the absence of dyspeptic symptoms. the pathogenesis of dyspepsia in peptic ulcer disease is unclear. whether the presence of helicobacter pylori infection or use of non-steroidal anti-inflammatory drugs affects dyspeptic symptoms in patients with peptic ulcer disease has not been determined. the aim of the study was to determine the frequency and risk factors for peptic ulcer disease in a cohort of asymptomatic, unselected patients undergoing routine screening e ...200415229422
personal history and family history as a predictor of gastric cardiac adenocarcinoma risk: a case-control study in taiwan.to clarify the risk of gastric cardiac adenocarcinoma for patients with a personal and/or family history of gastrointestinal diseases.200415233662
resistance rate to antibiotics of helicobacter pylori isolates in eastern taiwan.prevalence of helicobacter pylori (h. pylori) strains resistant to metronidazole, clarithromycin and amoxicillin is increasing worldwide. the aim of this study was to determine the antibiotic susceptibility patterns in h. pylori strains isolated from eastern taiwan.200717444862
helicobacter pylori infection: a protective factor for esophageal squamous cell carcinoma in a taiwanese population.many researchers have reported the inverse relationship between helicobacter pylori (h. pylori) infection and esophageal adenocarcinoma risk, but very few studies have examined the association between h. pylori infection and the development of esophageal squamous-cell carcinoma (escc). therefore, the aim of this study is to evaluate the relationship between h. pylori infection and escc risk.200515743356
presence of icea1 but not caga, cagc, cage, cagf, cagn, cagt, or orf13 genes of helicobacter pylori is associated with more severe gastric inflammation in taiwanese.the presence of the cag pathogenicity island (pai) may enhance the virulence of helicobacter pylori. this study determined the prevalence of genotypes of the pai, is605, and icea1 in h. pylori strains in taiwanese and whether these genotypes were related to the type of clinical disease or gastric pathology.200211911033
lewis blood genotypes of peptic ulcer and gastric cancer patients in taiwan.the lewis b (le(b)) antigen has been implicated as a possible binding site for attachment of helicobacter pylori (h pylori) to gastric mucosa. however, studies both supporting and denying this association have been reported in the literature. differences in secretor (se) genotype have been suggested as a possible reason for previous discrepancies. therefore, we investigated the relationship between le and se genotypes and h pylori infection rates in people with peptic ulcer or gastric cancer.200516097066
modification effects of gstm1, gstt1 and cyp2e1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer.incomplete intestinal metaplasia (im) is a precursor of stomach cancer. to identify risk factors of incomplete im, a 2-stage survey was carried out in 1995 among 1,485 residents in matzu, an area with highest mortality from stomach cancer in taiwan. there were 312 study subjects including 174 men and 138 women sampled for the gastroendoscopic examination of im. information on personal and familial history of stomach cancer, cigarette smoking, alcohol consumption and intake frequency of various s ...200414696128
the effects of eradication of helicobacter pylori on the recurrence of duodenal ulcers in patients with cirrhosis.the role of helicobacter pylori in patients with cirrhosis and increased prevalence of peptic ulcers is still poorly defined. the objective is to evaluate the effect of h pylori eradication on ulcer recurrence in patients with cirrhosis.200516111950
a seroepidemiologic study of helicobacter pylori and hepatitis a virus infection in primary school students in taipei.helicobacter pylori and hepatitis a virus (hav) share a common fecal-oral transmission route. the aim of this study was to investigate the prevalence of and risk factors for h. pylori and hav infection in primary school students in taiwan. we studied 289 grade 1 to 6 students from a single primary school in taipei county in 2003. the students volunteered for blood tests for h. pylori immunoglobulin g (igg) antibody and anti-hepatitis a antibody after consent from their parents. questionnaires we ...200515986067
association of nonsynonymous substitutions in the intermediate region of the vaca gene of helicobacter pylori with gastric diseases in taiwan.the amino acid sequences corresponding to the vaca intermediate region from 39 isolates of helicobacter pylori were investigated. the substitution of a g for the third s in the i1-type cluster b sequence (qasegitssk) conferred a greater risk of gastric diseases (p < 0.03; fisher's exact test). the conserved substitutions of an f for the y in the cluster a sequence and of an m for the second n in the i1-type cluster c sequence could be a marker of vaca in the taiwanese strains.200919020071
helicobacter pylori caga, icea and vaca genotypes in patients with gastric cancer in taiwan.helicobacter pylori (h pylori ) has been linked to chronic gastritis, peptic ulcer, gastric cancer and malt-lymphoma. the link of genotypes of h pylori to gastric cancer remains controversial. the aim of this study was to investigate the h pylori vaca alleles, caga and icea in patients with gastric cancer in taiwan.200415300891
the peopling of the pacific from a bacterial perspective.two prehistoric migrations peopled the pacific. one reached new guinea and australia, and a second, more recent, migration extended through melanesia and from there to the polynesian islands. these migrations were accompanied by two distinct populations of the specific human pathogen helicobacter pylori, called hpsahul and hspmaori, respectively. hpsahul split from asian populations of h. pylori 31,000 to 37,000 years ago, in concordance with archaeological history. the hpsahul populations in ne ...200919164753
a case-control study of association of helicobacter pylori infection with morbid obesity in taiwan.obesity is an increasing health problem in developed countries, where the prevalence of helicobacter pylori infection is decreasing. recent studies suggested colonization of the stomach by h pylori might affect gastric expression of appetite- and satiety-related hormone and patients cured of h pylori infection gained weight. it was hypothesized that h pylori could be a contributing pathogenic factor in childhood and adult obesity.200516009873
low molecular weight protein of helicobacter pylori and its relation to gastroduodenal diseases.in taiwan, caga and vaca cannot be used as markers to evaluate the risk of developing serious gastroduodenal pathogenesis in the hosts. recent research suggests that the low molecular weight proteins, 35kda and 19kda, in helicobacter pylori may be related to duodenal ulcers and gastric maltoma (mucosa-associated lymphoid tissue lymphoma) respectively. the aims of this study were to examine the sero-prevalence of antibodies against specific helicobacter pylori antigen in patients with different g ...200312845945
multistate and multifactorial progression of gastric cancer: results from community-based mass screening for gastric cancer.although multistate progression models for gastric cancer have been proposed, estimation of quantitative parameters of such models is yet to be done. the present study was conducted to elucidate risk factors for gastric cancer and its precursors, and to model the progression rates from superficial gastritis to gastric cancer. data were derived from a community-based screening programme for gastric cancer in the matzu region of taiwan. a total of 2184 residents participated in a two-stage screeni ...200617227633
rate of helicobacter pylori infection in children and clonality of taiwan strains.the infection rate of helicobacter pylori in children from < 1 to 17 years old was investigated. three techniques, namely culture, clo test, and pcr, were employed to check the presence or absence of the organism in the antrum of the stomach. several pcr positives without viable cultures were observed in babies of less than one year old. on the other hand, only two viable cultures were obtained from toddlers of less than two years old. the percentage of positive cultures steadily increased from ...200314638992
the role of helicobacter pylori infection in children with acute immune thrombocytopenic purpura.the outcome of immune thrombocytopenic purpura (itp) is classified as acute or chronic depending on whether platelet count returns to normal. the prevalence of helicobacter pylori infection increases with age and is independent of gender. we investigated the prevalence of h. pylori infection in chinese children from northern taiwan and analyzed the association between h. pylori infection and acute itp. our prospective cohort studies found no statistically significant relation between h. pylori i ...200616261593
long-term results of anti-helicobacter pylori therapy in early-stage gastric high-grade transformed malt lymphoma.several independent clinical studies have reported that helicobacter pylori eradication therapy could achieve complete remission in some patients with h. pylori-positive early-stage gastric mucosa-associated lymphoid tissue (malt) lymphoma.200516174856
helicobacter pylori infection is not associated with increased risk of colorectal polyps in taiwanese. 200616708392
genotypic characterization of helicobacter pylori caga and vaca from biopsy specimens of patients with gastroduodenal diseases.helicobacter pylor i infection is closely associated with gastroduodenal diseases. h. pylori infection with different vaca and caga genotypes may result in divergent consequences. the aim of the present study was to investigate the prevalence of h. pylori infection and the correlation between caga and vaca genotypes with the consequences of h. pylori infection in taiwan.200616758102
abnormal acid reflux in asthmatic patients in a region with low gerd prevalence.a high prevalence of gastroesophageal reflux disease (gerd) in asthmatic patients has been reported from north america and europe. however, only a few data from asia are available. this study evaluated the incidence of abnormal gastroesophageal reflux (ger) in asthmatic patients in taiwan.200515692784
evaluation of urine elisa test for detecting helicobacter pylori infection in taiwan: a prospective study.to evaluate the diagnostic accuracy and clinical utility of a new elisa (urinelisa) test for detecting helicobacter pylori (h pylori) antibody in the urine of taiwanese population.200516222752
short-term recurrent abdominal pain related to helicobacter pylori infection in children.the causal relationship between helicobacter pylori infection and recurrent abdominal pain in children is still under debate. this study assessed the relationship between h. pylori infection and recurrent abdominal pain (rap) in preschool and school children.200515740482
il-1b-511 c-->t polymorphism is associated with increased host susceptibility to helicobacter pylori infection in chinese.the heritability of helicobacter pylori infection from twin studies has been reported to be 0.66. however, few data were available on the host susceptibility to h. pylori infection in chinese. we aimed to evaluate the impact of the il-1b and il-1rn single-nucleotide polymorphisms (snp) and abo blood types on the host susceptibility to h. pylori infection.200717309751
high frequency of unusual gastric/duodenal ulcers in patients with behçet's disease in taiwan: a possible correlation of mhc molecules with the development of gastric/duodenal ulcers.the gastrointestinal (gi) involvement of behçet's disease (bd) mainly affects the ileocecal region and colon. the gastroduodenal mucosa appears to be the least frequently involved segment of the gastrointestinal tract. the objective of this study was to assess the severity of gastric/duodenal involvement in bd patients in taiwan. behçet's disease was diagnosed according to the diagnostic criteria issued by the international study group for behçet's disease. we obtained and recorded clinical and ...200515856366
polymorphism in cox-2 modifies the inverse association between helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in taiwan: a case control study.overexpression of cyclooxygenase-2 (cox-2) was observed in many types of cancers, including esophageal squamous cell carcinoma (escc). one functional snp, cox-2 -1195g/a, has been reported to mediate susceptibility of escc in chinese populations. in our previous study, the presence of helicobacter pylori (h. pylori) was found to play a protective role in development of escc. the interaction of cox-2 and h. pylori in gastric cancer was well investigated. however, literature on their interaction i ...200919463183
anthropology. where bacteria and languages concur. 200919164735
precancerous gastric conditions in high helicobacter pylori prevalence areas: comparison between eastern european (lithuanian, latvian) and asian (taiwanese) patients.the aim of the study was to compare the prevalence and severity of precancerous condition--gastric atrophy and intestinal metaplasia (im) between eastern european (lithuania and latvia) and asian (taiwan) countries in population older than 55 years.200717895638
anti-helicobacter pylori activity of plumbago zeylanica l.it has been shown that the presence of infection by helicobacter pylori is strongly associated with gastric cancer and peptic ulceration. in western medicine, a 3-fold therapeutic regimen, emphasizing the use of antibiotics, is typically used to suppress h. pylori activity. however, antibiotic drug resistance frequently develops as a consequence of such treatment. in our previous study, 50 taiwanese folk medicinal plants were screened for their anti-h. pylori activities. the results revealed tha ...200515708315
etiology and treatment of childhood peptic ulcer disease in taiwan: a single center 9-year experience.peptic ulcer disease (pud) in children is relatively rare as compared with adults. this study aimed to assess the etiology, clinical and histological characteristics, and treatment of pud in children.201020123589
helicobacter pylori infection and the risk of gastric malignancy.this prospective cohort study investigated the impact of helicobacter pylori infection on the development of various gastric malignancies.200717324128
seroprevalence of helicobacter pylori infection among schoolchildren and teachers in taiwan.helicobacter pylori are associated with chronic antral gastritis that is related to duodenal ulcer, gastric ulcer, and probably gastric adenocarcinoma. infection of h. pylori during childhood is considered an important risk factor for gastric carcinoma in adult life.200717493007
functional polymorphisms of cd14 and toll-like receptor 4 in taiwanese chinese with helicobacter pylori-related gastric malignancies.interindividual differences in degrees and extent of gastritis are responsible for the divergent outcomes after h. pylori infection. cellular responses in gastric inflammation are mediated by lipopolysaccharide of h. pylori, which activate monocytes to express cytokine expression and growth factors via cd14 and toll-like receptor 4 (tlr4). whether functional polymorphisms of tlr 4 and cd14 account for h. pylori-related gastric malignancies remains unknown. this study aimed to investigate the con ...200617086894
prevalence of helicobacter pylori infection in duodenal ulcer and gastro-duodenal ulcer diseases in taiwan.the prevalence of helicobacter pylori-negative duodenal ulcer (du) is increasing in western countries but is rare in japan. we aimed to examine the prevalence of h. pylori infection and the characteristics in du and gastro-duodenal ulcer (gdu) diseases in taiwan.201020074147
role of omeprazole dosage and cytochrome p450 2c19 genotype in patients receiving omeprazole-amoxicillin dual therapy for helicobacter pylori eradication.to determine the factors that may influence helicobacter pylori eradication in patients receiving omeprazole-amoxicillin dual therapy.201121361732
early helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease.helicobacter pylori (h pylori) is a risk factor for gastric cancer. we investigated whether early h pylori eradication is associated with gastric cancer risk in patients with peptic ulcer diseases.200919664631
matrix metalloproteinase-3 promoter polymorphisms but not dupa-h. pylori correlate to duodenal ulcers in h. pylori-infected females.this study investigated if the h. pylori dupa genotype and certain host single nucleotide polymorphisms (snps) of matrix metalloproteinases (mmps) and their inhibitors (timps), including mmp-3, mmp-7, mmp-9, timp-1 and timp-2, might correlate with ulcer risk of h. pylori-infected taiwanese patients.201020707923
effect of helicobacter pylori eradication therapy on risk of hospitalization for a major ulcer event.to compare helicobacter pylori eradication therapy with antisecretory therapy alone on the risk of hospitalization for a major ulcer event.201121361733
gut check: can cost-effectiveness analysis help eliminate gastric cancer in asia? 200717507608
gastric cardia adenocarcinoma in taiwanese men: positive associations due to selection bias.the factors associated with an increase in gastric cardia adenocarcinoma are poorly understood. environmental factors such as helicobacter pylori (h. pylori) infection and diet have been hypothesized to play a role in the recently increased risk of this disease, but additional studies are needed. in conducting studies to establish the relationship between potential risk factors and gastric cardia adenocarcinoma, it is necessary to carefully consider the role of bias. in a recently published stud ...201020333802
cost-effectiveness analysis between primary and secondary preventive strategies for gastric cancer.the present study is done to assess the relative cost-effectiveness, optimal initial age, and interscreening interval between primary and secondary prevention strategies for gastric cancer.200717507609
interleukin-1beta and -10 polymorphisms influence erosive reflux esophagitis and gastritis in taiwanese patients.helicobacter pylori (h. pylori) infection induces cytokine production and is associated with gastrointestinal diseases. this study examined the relationship of gene polymorphisms, including interleukin (il)-1beta, -10, -8, and tumor necrosis factor-alpha (tnf-alpha), h. pylori infection, and susceptibility to gastrointestinal disorders in taiwanese patients.201020659236
helicobacter pylori: antibiotic resistance and treatment options. 200919682186
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