| human metapneumovirus as a cause of community-acquired respiratory illness. | human metapneumovirus (hmpv) is a recently identified paramyxovirus first isolated from hospitalized children with acute respiratory tract infections (arti). we sought evidence of hmpv infection in patients who had visited general practitioners, had influenzalike illnesses (ili), and had negative tests for influenza and human respiratory syncytial virus (hrsv). as part of national virologic surveillance, sentinel general practices in england and wales collected samples from patients of all ages ... | 2002 | 12194763 |
| influenza-related hospitalizations among young children in leicestershire. | population-based data on influenza hospitalizations are unavailable in the united kingdom, but they represent an essential component of health economic analyses that could support the use of vaccines and antiinfluenza drugs in healthy children. we collected data on hospitalizations for influenza infections among young children in leicester, uk. | 2003 | 14551481 |
| detection of human metapneumovirus in respiratory secretions by reverse-transcriptase polymerase chain reaction, indirect immunofluorescence, and virus isolation in human bronchial epithelial cells. | over two winters in newcastle upon tyne, respiratory secretions, negative by immunofluorescence staining for other respiratory viruses, were tested for the presence of human metapneumovirus (hmpv) by rt-pcr. in the second winter, specimens were also tested by immunofluorescence staining with an anti-hmpv polyclonal rabbit antiserum and immunofluorescence positive specimens were inoculated into a line of human bronchiolar cells, 16hbe140. overall, 55 of 549 (10%) specimens tested were positive fo ... | 2006 | 16847967 |
| diagnosis of human metapneumovirus by immunofluorescence staining with monoclonal antibodies in the north-east of england. | since its discovery in 2001 human metapneumovirus (hmpv) has been shown to be a significant cause of human respiratory disease, responsible for 5-8% of respiratory infections in hospitalised children. diagnosis hitherto has been largely carried out by reverse tanscriptase polymerase chain reaction (rt-pcr) but immunofluorescence staining of cells from nasopharyngeal secretions (if) offers advantages for some laboratories and may produce a more rapid result in urgent cases. we have recently demon ... | 2007 | 17869169 |
| detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west england, uk. | human metapneumovirus (hmpv) causes a spectrum of respiratory disease ranging from trivial coryzal symptoms to fatal pneumonia, with a predilection for the very young, the immune suppressed and the frail elderly. five distinct lineages of the virus genome have been described. | 2008 | 18455957 |
| human metapneumovirus: a new threat? | | 2009 | 19478119 |
| Mycoplasma pneumoniae and respiratory virus infections in children with persistent cough in England: a retrospective analysis. | Persistent cough following an acute respiratory tract infection is common in children, but clinicians may find it difficult to give accurate prognostic information on likely duration of cough without a microbiologic diagnosis. This study estimates the prevalence of Mycoplasma pneumoniae (Mp) and assesses the prognostic value of detecting Mp and respiratory viruses in children with persistent cough. | 2011 | 21857262 |
| a new laboratory-based surveillance system (respiratory datamart system) for influenza and other respiratory viruses in england: results and experience from 2009 to 2012. | during the 2009 influenza a(h1n1) pandemic, a new laboratory-based virological sentinel surveillance system, the respiratory datamart system (rdms), was established in a network of 14 health protection agency (now public health england (phe)) and national health service (nhs) laboratories in england. laboratory results (both positive and negative) were systematically collected from all routinely tested clinical respiratory samples for a range of respiratory viruses including influenza, respirato ... | 2014 | 24480060 |
| respiratory viral infections during the 2009-2010 winter season in central england, uk: incidence and patterns of multiple virus co-infections. | acute viral respiratory infections are the most common infections in humans. co-infection with different respiratory viruses is well documented but not necessarily well understood. the aim of this study was to utilise laboratory data from the winter season following the 2009 influenza a(h1n1) outbreak to investigate rates of respiratory virus co-infections, virus prevalence in different age groups and temporal variations in virus detection. the health protection agency public health laboratory ( ... | 2012 | 22678349 |
| a human metapneumovirus outbreak at a community hospital in england, july to september 2010. | we describe an outbreak of human metapneumovirus (hmpv) which occurred in july-september 2010 at a community hospital in the east of england. based on the medical and nursing records, cases were retrospectively defined as suspected if they had had an influenza-like illness (ili), and probable if they had had an ili and an epidemiological link to a laboratory-confirmed case. of a total of 17 symptomatic inpatients, five were classified as probable cases, five were laboratory confirmed and seven w ... | 2012 | 22516049 |