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human papillomavirus and invasive cervical cancer in brazil.a hospital-based case-control study was undertaken to examine the role of human papillomavirus (hpv) in the development of invasive cervical cancer in brazil. the study included 199 histologically confirmed incident cases and 225 age-frequency-matched controls selected from a wide range of diagnostic categories. a polymerase chain reaction technique was used to detect hpv dna in cervical specimens collected with spatula and brush. hpv dna was detected in 84% of the cases compared with 17% of con ...19948286192
epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer.acquisition and clearance of cervical human papillomavirus (hpv) infection were analyzed among 1425 low-income women attending a maternal and child health program in são paulo, brazil. specimens collected every 4 months were tested by a polymerase chain reaction protocol (my09/11). in all, 357 subjects were positive at least once. there were 1.3% new infections per month, with 38% cumulative positivity after 18 months. of 177 positive subjects at enrollment, only 35% remained infected after 12 m ...199910515798
design and methods of the ludwig-mcgill longitudinal study of the natural history of human papillomavirus infection and cervical neoplasia in brazil. ludwig-mcgill study group.this article reports on a large longitudinal study, begun in 1993, of the natural history of human papillomavirus (hpv) infection and cervical neoplasia in a population of low-income women in são paulo, brazil, a city with one of the highest risks worldwide for cervical cancer. known as the ludwig-mcgill cohort study, the epidemiological investigation focuses on persistent infection with oncogenic hpv types as the precursor event leading to cervical neoplasia. the objectives of this study are to ...199910572472
relationship between human papillomavirus (hpv) genotyping and genital neoplasia in hiv-positive patients of santos city, são paulo, brazil.among hiv-positive women, infection with multiple human papillomavirus (hpv) types is known to be more frequent and persistent, as well as a greater prevalence of high-grade genital lesions. this study aims to characterize, for the first time in brazil, hpv presence and types among hiv-positive women of a high-risk population for genital intraepithelial neoplasia (gin) development. a non-anonymous, voluntary, cross-sectional epidemiological survey was conducted, from june 1996 to april 1997, amo ...199910639061
[hiv, hpv, and syphilis prevalence in a women's penitentiary in the city of são paulo, 1997-1998].incarcerated women as a group are particularly vulnerable to infections. the lack of public programs for prevention, early diagnosis, and treatment contribute to the increase in the incidence and prevalence of diseases in general and especially sexually transmitted diseases. this article aims to estimate the prevalence of infection by the human immunodeficiency virus (hiv), human papillomavirus (hpv), and syphilis among inmates at the women's penitentiary in the state capital of são paulo, brazi ...200111784908
evidence for chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in brazil and the philippines.chlamydia trachomatis infection was examined as a cause of invasive cervical cancer (icc) among women with human papillomavirus (hpv) infection. in total, 499 women with incident icc (icc patients) and 539 control patients from são paulo, brazil, and manila, the philippines, were included. c. trachomatis antibodies were detected by microimmunofluorescence assay. presence of hpv dna in cervical specimens was determined by a polymerase chain reaction-based assay. c. trachomatis seropositivity was ...200211807714
anogenital warts contributing to the risk of squamous intraepithelial lesions among hiv-positive women of são paulo, brazil.unsafe sexual practices may expose hiv-positive women to high-grade squamous intraepithelial lesions (sil) and to infection with oncogenic human papillomavirus (hpv) types. a cross sectional study of 141 hiv-positive women was designed to evaluate risk factors for the development of cervico-vaginal sil and hpv-dna detection/typing. uni- and multivariate forward stepwise analysis was used to determine the relationship between risk variables and hpv infection and between risk behaviour, hpv and hi ...200312803937
genetic damage in exfoliated cells of the uterine cervix. association and interaction between cigarette smoking and progression to malignant transformation?to determine, through the micronucleus (mn) test, the cytogenetic effects of cigarette smoking on exfoliated cells from the uterine cervix in women with normal smears and women with inflammatory atypia, squamous intraepithelial lesion (sil) (cervical intraepithelial neoplasia [cin] 1-3) and cervical cancer.19989622681
molecular strategies for identifying human papillomavirus infection in routinely processed samples: focus on paraffin sections.to optimize the protocols of human papillomavirus (hpv) detection in clinical samples, we used polymerase chain reaction (pcr)-based techniques in paraffin-embedded tissue sections and compared the results with those obtained with pcr and hybrid capture ii (hc2) performed in liquid-based cytology (lbc) preservation medium.200516205192
sexually transmitted disease/hiv risk behaviour among women who have sex with women.to analyse the epidemiological aspects of sexually transmitted diseases (std) among women who have sex with women (wsw) in são paulo, brazil.200516249657
human papillomavirus in the oral mucosa of women with genital human papillomavirus lesions.human papillomavirus (hpv) infection is one of the most common sexually transmitted diseases worldwide. we determined the frequency of hpv in the oral cavity of women with and without genital hpv lesions.200616324781
human papillomavirus (hpv) infections as risk factors for cytological and histological abnormalities in baseline pap smear-negative women followed-up for 2 years in the lams study.to assess the role of hpv as determinant of the incident cytological abnormalities (sil) and cervical lesions (cin) during a 24-month follow-up of baseline pap smear-negative subgroup of women included in the latin american screening study (lams).200716814450
[prevalence of genital hpv infection among women screened for cervical cancer].to assess the prevalence of high-risk genital human papillomavirus (hpv) infection by age group and risk factors associated.200818200349
diet and serum micronutrients in relation to cervical neoplasia and cancer among low-income brazilian women.cervical cancer is a leading cancer among women in developing countries. infection with oncogenic human papillomavirus (hpv) types has been recognized as a necessary cause of this disease. serum carotenoids and tocopherols have also been associated with risk for cervical neoplasia, but results from previous studies were not consistent. we evaluated the association of serum total carotene and tocopherols, and dietary intakes with the risk of newly diagnosed, histologically confirmed cervical intr ...201019642096
phylogenetic classification of human papillomavirus genotypes in high-grade cervical intraepithelial neoplasia in women from a densely populated brazilian urban region.differences in human papillomavirus (hpv) types may correlate with the biological potential and invasion risk of high-grade cervical intraepithelial neoplasia (cin 2 and cin 3). the objective of this study was to determine the relationship between different combinations of hpv types and cin severity.200919820871
epidemiologic correlates of cervical neoplasia and risk of human papillomavirus infection in asymptomatic women in brazil.to investigate whether the epidemiologic correlates of cervical cancer are predictors of infection with genital human papillomavirus (hpv), we performed a prevalence survey in two metropolitan areas of brazil, recife and são paulo. the data records of four randomly selected hpv-negative women were matched on the basis of age, clinic, and admission period with those of each of 136 patients with positive hpv dna hybridizations. anal intercourse [prevalence rate ratio (prr) = 1.7] and current pregn ...19892536815
human papillomavirus up-date. meeting held in são paulo, brazil, november 8-10, 1990. 19911673450
prevalence of and risk factors for anal human papillomavirus infection in men who have sex with women: a cross-national study.although the primary cause of anal cancer is human papillomavirus (hpv) infection in the anal canal, little attention has been paid to the epidemiology of anal hpv infection in men who have sex with women (msw).201020367457
no association between endogenous retinoic acid and human papillomavirus clearance or incident cervical lesions in brazilian women.although oncogenic human papillomavirus (hpv) infections have been established as the necessary cause of cervical cancer, most hpv infections are transient and rarely progress to squamous cervical lesions. the activity of hpv is tightly associated with epithelial cell differentiation; therefore, regulators of differentiation, such as retinoic acid (ra), have been considered targets for the prevention of hpv-associated squamous intraepithelial lesion (sil) development. the purpose of this study w ...201020606041
dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.women with human papillomavirus (hpv) infections are at risk for developing squamous intraepithelial lesions (sil) of the cervix; however, other factors are required for infections to progress to sil. we hypothesize that consumption of fruits and vegetables high in antioxidant nutrients may prevent, in part, the development of hpv-associated sil.201020691333
the epidemiology of laryngeal cancer in brazil.the city of são paulo exhibits one of the highest incidences of laryngeal cancer in world and brazil presents remarkable occurrence, compared with other latin american countries. around 8,000 new cases and 3,000 deaths by laryngeal cancer occur annually in the brazilian population. in the city of são paulo, incidence rates for laryngeal cancer among males have been decreasing since the late 1980s while, among females, the rates have shown a stable trend. this phenomenon is probably the expressio ...200415558139
associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking.smoking has been positively and fruit and vegetable intake has been negatively associated with cervical cancer, the second most common cancer among women worldwide. however, a lower consumption of fruits and reduced serum carotenoids have been observed among smokers. it is not known whether the smoking effect on the risk of cervical neoplasia is modified by a low intake of fruits and vegetables. the present study examined the combined effects of tobacco smoking and diet using a validated ffq and ...201021092390
prevalence of human papillomaviruses in urine samples of male patients infected with hiv-1 in sao paulo, brazil.human papillomavirus is a dna virus that includes 118 genotypes. hpv16 is responsible for 80% of cervical cancer in women. men are important reservoirs and major transmitters of hpv to their partners. the aim of this study was to detect hpv dna and to determine the prevalence of hpv types 6, 11, 16, and 18 in urine samples of men infected with hiv-1. this study included 223 patients infected with hiv-1 from the center of reference on hiv/aids (crt-sp) and an outpatient clinic of hiv. urine sampl ...200919856467
awareness and knowledge of hpv, cervical cancer, and vaccines in young women after first delivery in são paulo, brazil--a cross-sectional study.the success of hpv vaccination programs will require awareness regarding hpv associated diseases and the benefits of hpv vaccination for the general population. the aim of this study was to assess the level of awareness and knowledge of human papillomavirus (hpv) infection, cervical cancer prevention, vaccines, and factors associated with hpv awareness among young women after birth of the first child.201021176230
cervical cytology and histopathologic abnormalities in women living with aids in são paulo, brazil.women living with hiv/aids present with a higher prevalence of human papillomavirus (hpv) infection, higher rates of squamous intraepithelial lesions, and are more susceptible to invasive cervical carcinoma progression.201121857321
Six-month incidence, persistence, and factors associated with persistence of anal human papillomavirus in men: the HPV in men study.Although there are limited numbers of incidence and persistence estimates for anal human papillomavirus (HPV) in women and in men who have sex with men (MSM), there are no such reports for men who have sex with women (MSW).201121964400
The prevalence of genital HPV and factors associated with oncogenic HPV among men having sex with men and men having sex with women and men: the HIM study.Comparative studies of genital human papillomavirus (HPV) among men having sex with men (MSM), men having sex with women and men (MSWM), and men having sex with women (MSW) have not been conducted so far; however, such comparisons may be important for planning prevention strategies like vaccination.201121934568
cost of production of live attenuated dengue vaccines: a case study of the instituto butantan, sao paulo, brazil.a vaccine to prevent dengue disease is urgently needed. fortunately, a few tetravalent candidate vaccines are in the later stages of development and show promise. but, if the cost of these candidates is too high, their beneficial potential will not be realized. the price of a vaccine is one of the most important factors affecting its ultimate application in developing countries. in recent years, new vaccines such as those for human papilloma virus and pneumococcal disease (conjugate vaccine) hav ...201222406455
prevalence, distribution and correlates of endocervical human papillomavirus types in brazilian women.we determined the prevalence, distribution and correlates of human papillomavirus (hpv) types in 386 mixed-income, sexually active women in são paulo, brazil. endocervical samples were tested for hpv dna with l1 primers my09 and my11; negative and indeterminate samples were retested using gp 5+/6+ consensus primers. hpv was detected in 35% of all women; high-risk/probable high-risk types in 20%; low-risk types in 7%; and an indeterminate type in 10%. twenty-five hpv types were found overall: 17 ...201020089995
low prevalence of hpv in brazilian children with retinoblastoma.retinoblastoma is the most frequent intra-ocular malignant tumor of the childhood, occurring in 1 of 18,000-30,000 live births. little is known about the causes of sporadic retinoblastoma and only a few authors have investigated the etiologic role of human papillomavirus (hpv), with controversial results. formalin-fixed, paraffin-embedded tissue blocks containing retinoblastoma were retrieved from the archives of the department of pathology at hospital a c camargo, são paulo, brazil. all patient ...201121108347
seroprevalence of human papillomavirus 6, 11, 16, and 18 in young primiparous women in sao paulo, brazil.data on epidemiology of hpv infection are needed for the development of human papillomavirus (hpv) vaccine recommendations, especially in countries where hpv vaccination is not yet included in public vaccination programs. the aim of this study was to determine the prevalence of serum antibodies to hpv types 6, 11, 16, and 18 and associated factors among young women after birth of the first child.201021051985
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