| detection of a human papilloma virus type 5 dna in a renal allograft patient from scotland. | a renal allograft recipient with small raised red scaly lesions on a forearm is described. the clinical and histological picture was that of similar lesions reported in some epidermodysplasia verruciformis patients. virological investigations revealed the presence of human papilloma virus type 5; this is the second report of the occurrence of this type in allograft patients. as human papilloma virus type 5 is known to have malignant potential, clinicians should be on the lookout for these banal- ... | 1988 | 2854081 |
| a longitudinal study of hpv detection and cervical pathology in hiv infected women. | to monitor the presence and persistence of high risk (hr) human papillomavirus (hpv) in cervical brushings from hiv infected women. | 2000 | 11026879 |
| multiple high risk hpv infections are common in cervical neoplasia and young women in a cervical screening population. | if human papillomavirus (hpv) testing is to be included within cervical screening programmes, the importance of multiple hpv infections in cervical neoplasia needs to be determined. this study investigated the diversity of multiple hpv types in a routine cervical screening population, and assessed associations with cervical neoplasia. | 2004 | 14693839 |
| trial of management of borderline and other low-grade abnormal smears (tombola): trial design. | cervical screening reduces the risk of cervical cancer by detecting and treating cervical intraepithelial neoplasia (cin). the management of women with low-grade cervical abnormalities is controversial. two management policies exist: repeat smears in primary care and colposcopy examination. it is not clear which of these is the more effective and efficient. there is also uncertainty as to the most effective and efficient management of women at colposcopy when an area of abnormality is seen on th ... | 2006 | 16765101 |
| public awareness that hpv is a risk factor for cervical cancer. | we assessed awareness of human papillomavirus (hpv) in a population sample of british women (n=1620) using similar questions to those in a survey in 2002. only 2.5% cited hpv as the cause of cervical cancer without prompting; up from 0.9% in 2002. public education about hpv is urgently needed. | 2007 | 17687335 |
| predicted impact of vaccination against human papillomavirus 16/18 on cancer incidence and cervical abnormalities in women aged 20-29 in the uk. | human papillomavirus (hpv) vaccination has been approved in more than 90 countries and is being implemented in many of these. in the uk, vaccination for girls aged 12-13 with catch-up for girls up to age 18 was introduced in 2008, using the bivalent gsk vaccine (cervarix). | 2010 | 20104226 |
| distribution of hpv types associated with cervical cancers in scotland and implications for the impact of hpv vaccines. | this study evaluated human papillomavirus (hpv) type prevalence in 370 scottish invasive cervical cancers (iccs) using hpv genotyping and hpv mrna detection. | 2010 | 20145611 |
| hpv vaccination: vaccine acceptance, side effects and screening intentions. | as part of an evaluation of the introductory campaign of human papilloma virus (hpv) vaccine in a scottish health board, self-administered questionnaires were offered to all 5007 eligible girls in school following the third dose of hpv to identify side-effects, reasons for non-vaccination and future cervical screening intentions, and 2775 (56.2%) replied. in all, 630 (23.5%) of vaccinated girls reported side effects to the vaccination, about half of which were common injection-site reactions. ma ... | 2010 | 20586376 |
| knowledge and attitudes to reporting adverse drug reactions. | the reporting of adverse drug reactions (adrs) by health professionals forms an important component of ongoing surveillance of post-marketing drug safety. the extension of responsibility for all health professionals to report adrs has coincided with national immunization programmes, such as the national childhood immunization, human papillomavirus (hpv), and seasonal and h1n1 influenza programmes. the study objective was to evaluate knowledge of, and attitudes to, reporting adrs among the profes ... | 2010 | 20647982 |
| hpv type-specific prevalence using a urine assay in unvaccinated male and female 11- to 18-year olds in scotland. | we conducted a baseline prevalence survey of unvaccinated 11- to 18-year olds to inform effectiveness studies for the new human papillomavirus (hpv) immunisation programme in scotland. | 2011 | 21343934 |
| prevalence, risk factors, and uptake of interventions for sexually transmitted infections in britain: findings from the national surveys of sexual attitudes and lifestyles (natsal). | population-based estimates of prevalence, risk distribution, and intervention uptake inform delivery of control programmes for sexually transmitted infections (stis). we undertook the third national survey of sexual attitudes and lifestyles (natsal-3) after implementation of national sexual health strategies, and describe the epidemiology of four stis in britain (england, scotland, and wales) and the uptake of interventions. | 2013 | 24286785 |
| 'just that little bit of doubt': scottish parents', teenage girls' and health professionals' views of the mmr, h1n1 and hpv vaccines. | parental decision making about childhood vaccinations is complex and the vaccination schedule ever-changing. vaccination may be controversial even in countries with historically high vaccination rates such as scotland. health behaviour models have aided understanding of individual vaccine intentions for specific vaccines. these are limited in explaining actual behaviours and are divorced from the impact of socio-cultural contexts on vaccination decision making. | 2014 | 24198038 |
| adverse event monitoring of the human papillomavirus vaccines in scotland. | human papillomavirus (hpv) vaccines are currently utilised globally in national immunisation programmes. while evidence from clinical trials and epidemiological studies suggest that the hpv vaccines are both effective and safe, concerns about the safety of the vaccine and scientifically unproven associations with severe adverse events following immunisation have led to dramatic decreases in vaccine uptake in japan and acceptance issues in other countries. | 2016 | 26765074 |
| human papillomavirus prevalence and herd immunity after introduction of vaccination program, scotland, 2009-2013. | in 2008, a national human papillomavirus (hpv) immunization program using a bivalent vaccine against hpv types 16 and 18 was implemented in scotland along with a national surveillance program designed to determine the longitudinal effects of vaccination on hpv infection at the population level. each year during 2009-2013, the surveillance program conducted hpv testing on a proportion of liquid-based cytology samples from women undergoing their first cervical screening test for precancerous cervi ... | 2016 | 26692336 |
| population-based p16 and hpv positivity rates in oropharyngeal cancer in southeast scotland. | we assessed a population-based cohort of patients diagnosed with oropharyngeal squamous cell carcinoma in southeast scotland over 13 months. p16 and human papilloma virus (hpv) expression were determined, and correlated with stage, treatment, smoking and alcohol history, and disease outcomes. retrospective analysis was performed on 60 patients. p16 immunohistochemistry and hpv genotyping were performed on formalin-fixed paraffin-embedded tissues. hpv infection (as defined by p16 positivity and/o ... | 2015 | 26152733 |
| the views of young women on hpv vaccine communication in four european countries. | the human papilloma virus (hpv) is the most common sexually transmitted infection (sti) and can cause cervical cancer. two vaccines are available to protect against the most common strands of the virus. vaccination programs differ across europe but most neglect young adults, who are the group with the highest risk of contracting stis. our aim was to explore the views of young women from four european countries—scotland, spain, serbia, and bulgaria - about the hpv vaccine communication strategy. ... | 2015 | 26149158 |
| the costs of managing genital warts in the uk by devolved nation: england, scotland, wales and northern ireland. | genital warts, 90% of which are caused by human papillomavirus types 6 and 11, are a significant problem in the uk. the cost of managing genital warts was previously estimated at £52.4 million for 2010. the objective of this study was to estimate the cost of genital warts management up to 2012 in the uk and by jurisdiction. population statistics and the number of reported genital warts cases in genito-urinary medicine clinics were obtained and extrapolated to 2012. cases of genital warts treated ... | 2016 | 25681263 |
| human papilloma virus (hpv) oral prevalence in scotland (hopscotch): a feasibility study in dental settings. | the purpose of this study was to test the feasibility of undertaking a full population investigation into the prevalence, incidence, and persistence of oral human papilloma virus (hpv) in scotland via dental settings. male and female patients aged 16-69 years were recruited by research nurses in 3 primary care and dental outreach teaching centres and 2 general dental practices (gdps), and by dental care teams in 2 further gdps. participants completed a questionnaire (via an online tablet compute ... | 2016 | 27861508 |
| high uptake of hpv immunisation in scotland--perspectives on maximising uptake. | in september 2008, scotland introduced a national human papillomavirus (hpv) immunisation programme with bivalent hpv vaccine, to prevent cervical cancer. this school-based programme routinely vaccinates girls aged between 12 and 13 years. a catch-up campaign, running over three years, also began at this time, offering vaccination to all girls aged 13 years to under 18 years old. the hpv immunisation campaign presented challenges due to this vaccine being targeted to girls in school and older gi ... | 2013 | 24094062 |
| young women's constructions of the hpv vaccine: a cross-cultural, qualitative study in scotland, spain, serbia and bulgaria. | following international trends, the hpv (human papilloma virus) vaccine was introduced in europe for protection against infection from common strands of the hpv virus which can lead to cervical cancer. young women aged 18-26 years are at greatest risk of infection by the hpv virus yet have been neglected in research, policy, and practice. | 2014 | 24092427 |
| cervical cancers associated with human papillomavirus types 16, 18 and 45 are diagnosed in younger women than cancers associated with other types: a cross-sectional observational study in wales and scotland (uk). | most cervical cancers are attributable to infection with one of fourteen types of human papillomavirus (hpv), but hpv types differ in oncogenic potential. characterisation of cancers associated with specific hpv types is required to predict the likely impact of current prophylactic vaccines and the potential benefits of vaccine formulations including additional hpv types. | 2013 | 24051043 |
| achieving high and equitable coverage of adolescent hpv vaccine in scotland. | the national immunisation records of over 220,000 girls offered vaccine in the routine or catch-up programme of the human papillomavirus (hpv) programme in scotland were analysed. descriptive statistics and multilevel modelling were used to determine individual and organisational factors associated with uptake. age, school year, school denomination, deprivation and, for school-leavers, mode of delivery were explored. additional aggregate data were used to examine the effect of late uptake of mis ... | 2014 | 23986492 |
| gaps in detailed knowledge of human papillomavirus (hpv) and the hpv vaccine among medical students in scotland. | a vaccination programme targeted against human papillomavirus (hpv) types 16 and 18 was introduced in the uk in 2008, with the aim of decreasing incidence of cervical disease. vaccine roll out to 12-13 year old girls with a catch-up programme for girls aged up to 17 years and 364 days was accompanied by a very comprehensive public health information (phi) campaign which described the role of hpv in the development of cervical cancer. | 2013 | 23521847 |
| the impact of bivalent hpv vaccine on cervical intraepithelial neoplasia by deprivation in scotland: reducing the gap. | cervical cancer disproportionately affects women from lower socioeconomic backgrounds. a human papillomavirus (hpv) vaccination programme was introduced in scotland in 2008 with uptake being lower and inequitable in a catch-up cohort run for the first three years of the programme compared with the routine programme. the socioeconomic differences in vaccine uptake have the potential to further increase the inequality gap in regards to cervical disease. | 2017 | 28756395 |
| prevalence of human papillomavirus types 16 and 18 in cervical adenocarcinoma and its precursors in scottish patients. | our aim was to determine the prevalence of human papillomavirus (hpv) types 16 and 18 in cervical adenocarcinoma (and its precursors) in scottish patients. nucleic acid was extracted from paraffin-embedded, formalin-fixed tissues. we examined 119 cases of invasive adenocarcinoma, 20 cases of adenocarcinoma in situ, and 16 cases of normal glandular epithelium. hpv dna was detected by polymerase chain reaction using type-specific primers for the e6 and e7 genes of hpv-16 and hpv-18 with conformati ... | 2006 | 16803480 |
| oral contraceptives and cervical cancer--further findings from the oxford family planning association contraceptive study. | in 1983, we reported results from the oxford family planning association contraceptive study regarding the association between oral contraceptives (ocs) and cervical neoplasia, after a 10 year follow-up of a cohort of 17,000 women. further findings from this study are reported here after an additional 12 years of follow-up. a nested case--control design was used in which cases were all women diagnosed under 45 years of age with invasive carcinoma (n = 33), carcinoma in situ (n = 121) or dysplasi ... | 1996 | 8630295 |
| human papillomavirus infection is rare in nonmalignant tonsil tissue in the uk: implications for tonsil cancer precursor lesions. | the incidence of human papillomavirus (hpv)-associated tonsil cancer is increasing but the prevalence of hpv, and of premalignant precursors, in tonsil tissue is unknown. we aimed to assess prevalence of hpv infection in nonmalignant tonsillar crypt epithelia and to histopathologically characterise positive samples. formalin-fixed paraffin-embedded (ffpe) tonsil tissue specimens were obtained from an age- and sex-stratified random sample of patients aged 0-69 years whose paired tonsils were arch ... | 2014 | 24723209 |