| diagnostic sensitivity of polymerase chain reaction and southern blot hybridization for the detection of human papillomavirus dna in biopsy specimens from cervical lesions. | human papillomaviruses (hpvs) are associated with benign and malignant neoplasms of the cervix. one of the criteria for their etiologic role requires an assessment of whether virtually all or only a small fraction of lesions contain viral genomes. dna preparations from colposcopically directed punch biopsies of cervical lesions were analyzed by southern blot hybridization and the polymerase chain reaction (pcr) for the presence of hpv dna. the biopsy specimens represented different pathologic en ... | 1991 | 1850950 |
| genital human papillomavirus infection among women from major ethnic groups in singapore. | the close epidemiological relationships between specific genital human papillomavirus (hpv) types and neoplasia of the cervix uteri have been extensively documented worldwide, including singapore. cervical cancer incidence rates in singapore show variations between the major ethnic groups. to ascertain the corresponding hpv infection rates among the various races in singapore, we analysed the cervical smears of 225 women by filter in situ dna hybridization, and compared the data with a previous ... | 1990 | 1966000 |
| is genital human papillomavirus infection always sexually transmitted? | the occurrence of genital human papillomavirus (hpv) infection was studied prospectively by colposcopy and histology in 43 virginal and 162 sexually active women attending a colposcopy clinic. the study also included 111 husbands of the latter group. by colposcopic criteria, the prevalence of hpv infection was 51.1% in the virginal and 69.1% in the sexually active women. the prevalence was 77.1% among men whose wives had hpv infection compared to 13.3% among men whose wives did not have the infe ... | 1990 | 2256864 |
| role of herpes simplex virus type-2 and human papilloma virus in penile cancers in singapore. | to detect the presence of herpes simplex virus type 2 (hsv-2) and human papilloma virus (hpv), common structural antigens in penile cancers, 20 squamous cell carcinomas were studied by immunohistochemical methods. all specimens were from singaporeans ranging in age from 44 to 69 years. none of the specimens contained hsv-2 and hpv common structural antigens. the reasons for the absence of hpv common antigen were discussed. the significance of the association of hpv with penile cancers is uncerta ... | 1987 | 2829697 |
| human papillomavirus in dysplasia and carcinoma of the cervix in singapore. | a prospective study was conducted in singapore in 1985 where 107 women with abnormal cervical smears were studied for cervical neoplasia and its association with the human papillomaviruses (hpv), using hpv 11, 16 and 18 dna as probes. cervical biopsies were performed for histology as well as for dna southern blot hybridization studies to detect the presence of hpv 11, 16 or 18 genome. the prevalence of the various types of papillomavirus dna in cervical tissue samples from cervical carcinoma and ... | 1988 | 2853859 |
| atypical condylomas of the cervix uteri in singapore women: a histopathological and immunohistochemical study. | subclinical flat cervical warts are commonly recognized by means of colposcopy. these warty lesions frequently contain cellular atypia of a varying degree showing all the features of cervical intraepithelial neoplasia (cin) together with the features of wart virus infection e.g. koilocytosis. human papillomavirus (hpv) antigens and dna have been found in these lesions which can be called atypical condylomas. the presence of such markers in lesions regarded as having neoplastic potential implicat ... | 1986 | 3021107 |
| human papillomavirus dna testing in community screening for diseases of the cervix uteri. | | 1996 | 8869401 |
| phylogenetic analysis of the human papillomavirus type 2 (hpv-2), hpv-27, and hpv-57 group, which is associated with common warts. | human papillomavirus types 2 (hpv-2), hpv-27, and hpv-57, are three closely related viruses within the phylogenetic supergroup formed by the remotely related genital papillomaviruses. in contrast to this phylogenetic association, these three viruses are most often found in common warts at nongenital sites, but also occasionally in genital warts and mucosal lesions of the nasopharyngeal cavity. we studied the genomic diversity of hpv sequences in skin warts presumably caused by these viruses. the ... | 1997 | 9434721 |
| a comparative study of cervical cytology, colposcopy and pcr for hpv in female sex workers in singapore. | this study examined the prevalence of human papillomavirus (hpv) infection in a cohort of female sex workers in singapore. hpv infection was diagnosed by clinical examination, papanicolaou (pap) smears, histology and polymerase chain reaction (pcr). one hundred and eighty-seven female sex workers who came for their routine medical screening were enrolled into the study. pcr was positive for hpv in 27 (14.4%), 20 of these had a single hpv type detected, while 7 had multiple types of hpv detected. ... | 2001 | 11231868 |
| human papillomavirus triage of patients with atypical squamous cells of undetermined significance on cervical papanicolaou smear. | the recent development of affordable human papillomavirus (hpv) testing has prompted consideration of its use as adjuvant and primary screening for cervical dysplasia. this review focuses on the use of hpv testing in triage management of atypical squamous cells of undetermined significance (asc-us) pap smears. | 2003 | 14626785 |
| epidemiology of human papillomavirus infection and cervical cancer and future perspectives in hong kong, singapore and taiwan. | hong kong, singapore and taiwan are three island states that are newly emerged affluent economic areas in asia. the majority of the populations are ethnically chinese with a total population of 6.98, 4.5 and 23 million, respectively. cervical cancer has been declining over the last thirty years in all three states and is largely attributable to widespread opportunistic cervical cancer screening. the age-standardized incidence rates of cervical cancer are 9.6 per 100,000 women in hong kong in 200 ... | 2008 | 18945415 |
| the prevalence and significance of high-risk human papillomavirus dna test in southern malaysia and singapore. | to investigate the prevalence of high-risk human papillomavirus (hpv) and its associated cytological abnormalities among women attending cervical screening clinics in southern malaysia and singapore. | 2009 | 19566569 |
| singaporean women's knowledge of human papillomavirus (hpv) and attitudes toward hpv vaccination. | with a vaccination program currently planned to protect singaporean women from human papillomavirus, a need arises for assessing singaporean women's knowledge of human papillomavirus and attitudes toward human papillomavirus vaccination to identify barriers to a successful program and to help inform health education campaigns. a representative sample of 2,145 women aged between 18 and 49 years were randomly selected from households throughout singapore and interviewed with a similar questionnair ... | 2009 | 19753508 |
| assessing knowledge of human papillomavirus and collecting data on sexual behavior: computer assisted telephone versus face to face interviews. | education campaigns seeking to raise awareness of human papillomavirus (hpv) and promoting hpv vaccination depend on accurate surveys of public awareness and knowledge of hpv and related sexual behavior. however, the most recent population-based studies have relied largely on computer-assisted telephone interviews (cati) as opposed to face to face interviews (ftfi). it is currently unknown how these survey modes differ, and in particular whether they attract similar demographics and therefore le ... | 2009 | 19930668 |
| cost-effectiveness of different human papillomavirus vaccines in singapore. | human papillomavirus (hpv) vaccines are widely available and there have been studies exploring their potential clinical impact and cost-effectiveness. however, few studies have compared the cost-effectiveness among the 2 main vaccines available - a bivalent vaccine against hpv 16/18, and a quadrivalent vaccine against 6/11/16/18. we explore the cost-effectiveness of these two hpv vaccines in tropical singapore. | 2011 | 21453537 |
| the impact of cytology screening and hpv vaccination on the burden of cervical cancer. | aim: to evaluate the impact of different strategies of human papillomavirus (hpv) vaccination on the burden of cervical cancer in singapore. methods: the incidence of cervical cancer was calculated using a markov model with inputs based on singapore data for the prevalence of hpv infection, socioeconomic characteristics and screening prevalence. the evaluation was performed for 10 scenarios: no screening, current opportunistic cytology screening, ideal optimal screening, universal adolescent h ... | 2011 | 21585695 |
| high-risk hpv genotypes and p16ink4a expression in a cohort of head and neck squamous cell carcinoma patients in singapore. | human papillomavirus (hpv), especially hpv16 genotype, is associated with oropharyngeal squamous cell carcinoma (opscc). we aim to determine the prevalence and characterize the high-risk (hr)-hpv genotypes in head and neck scc (hnscc) in a south-east asian multi-ethnic society in singapore and examine its prognostic significance.159 hnscc archival tissue samples were retrieved and tumour dna was screened for 18 hr-hpv genotypes using a pcr-based assay (qiagen, digene hpv genotyping rh test). p16 ... | 2016 | 27893418 |
| knowledge, attitudes and practices regarding human papillomavirus vaccination among young women attending a tertiary institution in singapore. | this study aimed to describe the knowledge, attitudes and practices of young women regarding human papillomavirus (hpv) vaccination. | 2016 | 27353611 |
| incidence, trends and ethnic differences of oropharyngeal, anal and cervical cancers: singapore, 1968-2012. | in recent decades, several western countries have reported an increase in oropharyngeal and anal cancers caused by human papillomavirus (hpv). trends in hpv-associated cancers in asia have not been as well described. we describe the epidemiology of potentially hpv-related cancers reported to the singapore cancer registry from 1968-2012. analysis included 998 oropharyngeal squamous cell carcinoma (opscc), 183 anal squamous cell carcinoma (ascc) and 8,019 invasive cervical cancer (icc) cases. addi ... | 2015 | 26720001 |
| interactions between clinical factors, p16, and cyclin-d1 expression and survival outcomes in oropharyngeal and hypopharyngeal squamous cell carcinoma. | p16 and cyclin-d1 are cell cycle proteins commonly dysregulated in head and neck carcinoma. we assessed their expression, clinicopathological variables, and overall survival (os) in oropharyngeal and hypopharyngeal squamous cell carcinoma (scc). | 2015 | 24953865 |
| human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in asia. | independent, prospective, multicenter, hospital-based cross-sectional studies were conducted across 5 countries in asia, namely, malaysia, vietnam, singapore, south korea, and the philippines. the objectives of these studies were to evaluate the prevalence of human papillomavirus (hpv) types (high risk and others including coinfections) in women with invasive cervical cancer (icc) and high-grade precancerous lesions. | 2013 | 23221730 |
| are there socioeconomic disparities in women having discussions on human papillomavirus vaccine with health care providers? | human papillomavirus (hpv) vaccine recommendation by a health care provider (hcp) is an important predictor of vaccine receipt. we examined whether being of a minority race/ethnicity, having lower income and education, and the lack of health insurance and a regular hcp are each associated with a lower likelihood of a discussion on hpv vaccine occurring between a woman and her hcp. | 2012 | 23033931 |
| health and economic burden of hpv-related diseases in singapore. | to assess the health and economic burden of human papillomavirus (hpv)-related diseases (cervical cancer, cervical intraepithelial neoplasia (cin) 1/2/3, and genital warts) in singapore over a period of 25 years beginning in 2008. | 2012 | 22502690 |