| carcinoma of the lung in okinawa, japan: with special reference to squamous cell carcinoma and squamous metaplasia. | in okinawa, a subtropical island in southern japan, squamous cell carcinoma (scc), especially the well-differentiated form, is prevalent, while this form is relatively rare in both the mainland and other countries (e.g. united states of america). more patients with scc from okinawa, moreover, were positive for human papillomavirus (hpv) dna by polymerase chain reaction (pcr) (79%), and harbored hpv types 6, 16 and 18, in combination. on the other hand, less than 30% of the mainland patients were ... | 1997 | 9361099 |
| comparative study of oral squamous cell carcinoma in okinawa, southern japan and sapporo in hokkaido, northern japan; with special reference to human papillomavirus and epstein-barr virus infection. | in okinawa, a subtropical island in southern japan, the incidence of oral squamous cell carcinoma is 1.5 times higher than that in mainland japan. sixty cases of oral squamous cell carcinoma from 1993 to 1996 in okinawa and 42 cases over the same period in sapporo were examined histologically. human papillomavirus (hpv) and epstein-barr virus (ebv) were detected by polymerase chain reaction (pcr) amplification with primers specific for hpv and ebv. in situ hybridisations of the viruses were also ... | 2000 | 10718402 |
| prognostic implication of human papillomavirus infection in squamous cell carcinoma of the lung. | on the subtropical island of okinawa, squamous cell carcinoma (scc), particularly the well-differentiated form, is the most frequent type of lung cancer, while this form is relatively rare on the japanese mainland and in other countries. furthermore, in okinawa, in 1993, 80% of scc cases of the lung were found to be infected with human papillomavirus (hpv). we studied the prognosis of scc of the lung with hpv infection (n = 25) and compared it with non-hpv-infected scc (n = 16). using the kaplan ... | 2000 | 10782464 |
| recent striking changes in histological differentiation and rate of human papillomavirus infection in squamous cell carcinoma of the lung in okinawa, a subtropical island in southern japan. | the incidence of lung cancer in okinawa has been the highest in japan since 1975, and squamous cell carcinoma (scc), especially the well differentiated form, is the most prevalent form in okinawa, although well differentiated scc is relatively rare in mainland japan. furthermore, a high proportion of scc of the lung in okinawa was positive for human papillomavirus (hpv). in this study, we report recent striking changes in histological features and in the incidence of hpv infection. | 2000 | 11041057 |
| detection of human papillomavirus dna in primary and metastatic lesions of carcinoma of the cervix in women from okinawa, japan. | of 351 patients with invasive cervical cancer treated at ryukyu university hospital, okinawa, 293 who were tested for human papilloma virus (hpv) dna of the primary cervical lesion before the initiation of treatment were considered for the study. the polymerase chain reaction (pcr) was performed using fresh specimens, immediately after sampling. in 250 of 293 patients (85.3%), hpv dna was detected in cervical tumor by pcr using l1 consensus primer. the positive rate by histology was 89.9% in squ ... | 2001 | 11319292 |
| prevalence of human papillomavirus in cervical swabs in the okinawa islands, japan. | although human papillomavirus (hpv) is the main risk factor for invasive cervical cancer, the mechanisms of developing carcinoma are not entirely understood. in particular, the biology and natural history of hpv infection are still unknown. therefore, we have investigated the incidence of human papillomavirus infection by polymerase chain reaction (pcr) in cervical swabs obtained from women who had cervical cancer screening in three separate areas of the islands of okinawa. the prevalence of hpv ... | 2002 | 12439548 |
| epstein-barr virus (ebv)-related oral squamous cell carcinoma in okinawa, a subtropical island, in southern japan--simultaneously infected with human papillomavirus (hpv). | up to now, many authors have reported on the ebv infection and its carcinogenic importance in undifferentiated nasopharyngeal carcinoma (who classification, type iii), but the infection of the virus in well differentiated oral squamous cell carcinoma has not been well described. we introduce the ebv-related well differentiated oral squamous cell carcinomas in okinawa, a subtropical island in the southernmost part of japan. this study aimed to clarify the pathogenesis of this malignancy in this a ... | 2003 | 12676263 |
| low prevalence of hpv infection and its natural history in normal oral mucosa among volunteers on miyako island, japan. | to investigate the prevalence of human papillomavirus (hpv) infection in normal oral mucosa, and to observe the natural history in the oral cavity in oral swab samples collected from healthy volunteers on miyako island, okinawa, japan. | 2004 | 15243477 |
| epidemiological study in okinawa, japan, of human papillomavirus infection of the uterine cervix. | to investigate the prevalence and type distribution of human papillomavirus (hpv) in women with normal cervical cytology and with cervical intraepithelial neoplasia i to iii(cin) or carcinoma of the cervix in okinawa, japan. | 2005 | 16011997 |
| prevalence and clinical features of human papillomavirus in head and neck squamous cell carcinoma in okinawa, southern japan. | previous studies from okinawa, a subtropical island in southern japan, demonstrated a higher prevalence of human papillomavirus (hpv) in oral carcinoma and a higher incidence of oral and pharyngeal carcinoma than those for mainland japan. the present study aims to investigate epidemiologic and clinical features of hpv in head and neck squamous cell carcinoma (hnscc) in okinawa. a total of 150 dna samples from 150 okinawan patients with head and neck squamous cell carcinoma (hnscc) were screened ... | 2011 | 21328000 |