| the physical state of human papillomavirus type 16 dna in cervical carcinomas of hong kong chinese. | the presence of human papillomavirus (hpv) in 15 cervical carcinoma specimens obtained from hong kong chinese patients was analyzed by southern blot hybridization studies. in nine (60%) of them, hpv 16 genomes were detected, while two others (13.3%) were found to harbor hpv dna of unknown type closely related to hpv 16. all of them were classified as squamous cell carcinomas according to who guidelines. in addition, the presence of hpv 18 was shown in another two (13.3%) squamous cell carcinoma ... | 1991 | 1653409 |
| prevalence of low and high risk human papillomavirus types in cervical cells from hong kong pregnant chinese using filter in situ hybridization. | filter in situ hybridization, using separate probes for human papillomavirus deoxyribonucleic acid types 6, 11, 16 and 18, was used to determine the prevailing hpv types amongst a group of pregnant chinese women. this group had been previously identified using a mixture of probes for hpv types 6, 11, 16, 18, 31, 33, 35 (virapap). specimens from six of the eleven cases contained one hpv type (55%) while five were positive for two types (45%). the "low-risk" types (hbv6, 11) were identified as fre ... | 1991 | 1654045 |
| human papillomavirus 6, 11, and 16 in laryngeal papillomas. | twenty-seven cases of benign laryngeal papillomas, both single and multiple variants, were analysed for human papillomavirus (hpv) by dna slot-blot hybridization chiefly to determine the pattern of infection in hong kong chinese. dna was extracted from paraffin blocks of formalin-fixed tissue and probed separately for hpv 6, 11, 16, and 18. sixteen cases (59 per cent) showed the presence of at least one of these four hpv genomes. thirteen cases (48 per cent) were positive for hpv 11 only. three ... | 1991 | 1662265 |
| human papillomavirus infection in the cervix of pregnant females in hong kong. | routine cytological examination and hpv-dna probing were performed on cervical cells obtained from 215 pregnant chinese females. the procedure utilized the specific binding of a mixture of complementary [32p]-labelled rna probes to membrane-bound target hpv dna types 6, 11, 16, 18, 31, 33 and 35. positive results for hpv-dna were obtained in 11/215 (5%) of the cases. the cervical smears were routinely processed and in 3/215 (1.5%) cases a cytological diagnosis of wart virus infection was made. a ... | 1990 | 1966325 |
| reproductive and sexual risk factors and human papilloma virus infection in cervical cancer among hong kong chinese. | in this case-control study of cervical neoplasia in hong kong, 48 dysplasia and 68 cancer patients were matched with 116 surgical in-patient controls. the cases had an earlier age at first intercourse and more sex partners than the controls. the cases' husbands also had more sex partners and were less likely to use condoms regularly. in a multiple regression model the odds ratio were 6.0 (95% confidence interval 2.5-14.6) for the husband having more than one sex partner, 4.0 (1.5-10.7) for the w ... | 1989 | 2542172 |
| cervical human papilloma virus infection of women attending social hygiene clinics in hong kong. | to find the prevalence of hpv infection in women attending a sexually transmitted disease clinic in hong kong. | 1993 | 8098299 |
| human papillomavirus infection in hong kong chinese women with normal and abnormal cervix--detection by polymerase chain reaction method on cervical scrapes. | detection of human papillomavirus (hpv) was accomplished by utilizing polymerase chain reaction methods on cervical scrapes from a total of 488 hong kong chinese women attending the colposcopy, general, and antenatal clinics. from colposcopy clinic, 10% of normal cervix, 31% of condyloma, 56, 50, and 57% of cin i, cin ii, and cin iii, respectively, and 88% of squamous cell carcinoma contain hpv. the overall detection rate is 30%. the most prevalent type is 16. four percent of scrapes from normal ... | 1996 | 8631541 |
| presence of human papillomavirus in esophageal squamous cell carcinomas of hong kong chinese and its relationship with p53 gene mutation. | there is no scientific study that has investigated the association between human papilloma virus (hpv) and p53 mutation in hong kong chinese patients with esophageal cancers. the aim of this survey is to evaluate in details the prevalence and relationship of hpv and p53 mutation in these patients with esophageal squamous cell carcinomas. fresh tissues from the resected specimens of 70 chinese patients (59 men, 11 women) with primary esophageal squamous cell carcinomas (20 well-differentiated, 36 ... | 1997 | 9190999 |
| p53 polymorphism and human papillomavirus infection in hong kong women with cervical cancer. | in this study we investigated the involvement of p53 polymorphism at codon 72, the infection and typing of human papillomavirus (hpv) and the correlation of p53 polymorphism with hpv type and other clinicopathologic characteristics in 72 hong kong women with cervical cancer. we developed a simple and nonradioactive method for determining polymorphism at codon 72 of the p53 gene. the homozygous p53 arginine allele (arg/arg) was detected in 22 (31%), the homozygous p53 proline allele (pro/pro) in ... | 2000 | 10895031 |
| human papillomavirus infection in non-neoplastic uterine cervical disease in hong kong. | the polymerase chain reaction (pcr) was used to detect and identify human papillomavirus (hpv) in 108 cases of formalin-fixed, paraffin-embedded, non-neoplastic uterine cervical biopsy tissue retrieved from the surgical pathology archives of the department of pathology, caritas medical centre, hong kong. after dna extraction, hpv l1 gene primers were used to detect the presence of hpv, and type-specific primers (to hpv types 6, 11, 16, 18, 31 and 33) were used to identify the specific hpv type o ... | 2001 | 11440211 |
| determinants of cervical human papillomavirus infection: differences between high- and low-oncogenic risk types. | this cross-sectional survey assessed the determinants of human papillomavirus (hpv) infections among 2080 women who participated in cervical cancer screening. hpvs were typed by restriction and sequencing analyses. the prevalence of hpv was 7.3% (4.2% for high-risk, 1.9% for low-risk, and 2.1% for unknown-risk types). high-risk hpv prevalence decreased with age, whereas low- and unknown-risk hpvs had a second peak in older women. young age was the only common variable associated with the 3 group ... | 2002 | 11756978 |
| association of human papillomavirus type 58 variant with the risk of cervical cancer. | human papillomavirus (hpv) type 58 has been found to be prevalent among chinese patients with cervical cancer. this study examined the oncogenic risk of hpv58 variants in hong kong, a southern part of china. altogether, 1924 women were studied: 42.8% with a normal cervix, 16.2% with cervical intraepithelial neoplasia (cin) i, 12.7% with cin ii, 20.8% with cin iii, and 7.6% with invasive cervical cancer (icc). the overall prevalence of hpv58 was 11.4% (220) and increased statistically significant ... | 2002 | 12189229 |
| human papillomavirus type 16 intratypic variant infection and risk for cervical neoplasia in southern china. | a case-control study was conducted on 1986 hong kong women to assess the risk of human papillomavirus (hpv) type 16 variants for cervical neoplasia. in total, 255 women were hpv-16 positive and were analyzed for e6 and e7 sequence variation. two novel substitutions at e6 (t86i and q116e) and 1 at e7 (r66w) were found. most hpv-16 variants were of asian (50.6%) or european (44.3%) lineage, and both lineages showed similar risk associations for high-grade and invasive cervical neoplasia. no increa ... | 2002 | 12195358 |
| genotype spectrum of cervical human papillomavirus infection among sexually transmitted disease clinic patients in hong kong. | previous studies have suggested that a few uncommon human papillomavirus (hpv) genotypes are prevalent in chinese cervical cancer patients. to elucidate the genotype spectrum of hpvs circulating among hong kong chinese, a cross-sectional study was conducted on 553 women who attended a public sexually transmitted disease clinic. hpv dna was detected from cervical samples using the polymerase chain reaction, followed by genotype identification based on restriction fragment length polymorphism and ... | 2002 | 12210419 |
| viral load, e2 gene disruption status, and lineage of human papillomavirus type 16 infection in cervical neoplasia. | the clinical utility of human papillomavirus (hpv) load and integration status remains unclear. we applied refined methods to delineate the viral load, integration status, and lineage of 104 women with hpv-16 monotype infection, including 19 with normal cervices, 9 with histologically proven cervical intraepithelial neoplasia (cin) 1, 24 with cin 2, 27 with cin 3, and 25 with squamous cell carcinoma (scc). higher crude viral load, as determined by real-time polymerase chain reaction (pcr) target ... | 2006 | 17109343 |
| human papillomavirus dna and liquid-based cervical cytology cotesting in screening and follow-up patient groups. | to compare the use of human papillomavirus (hpv) dna and cervical cytology cotesting in screening and follow-up of patients with previous cervical abnormalities and to assess the significance of a positive hpv dna test result in re-screening of cytologically normal cases. | 2006 | 17152273 |
| new evidence for geographic variation in the role of human papillomavirus in tonsillar carcinogenesis. | our previous studies of tonsillar cancers from new south wales, australia, and jilin province in the north-east of china, provided evidence that the proportion of these cancers attributable to human papillomavirus (hpv) varies geographically. this study provides the first data on hpv in tonsillar cancers from hong kong. | 2007 | 17454751 |
| association between hla-drb1 polymorphism, high-risk hpv infection and cervical neoplasia in southern chinese. | multiple determinants are involved in the progression of human papillomavirus (hpv)-infected cervical lesion to invasive cancer. human leukocyte antigen (hla) polymorphism seems to play a role. this study examined the association between hla-drb1 polymorphism, high-risk hpv infection, and the development of cervical neoplasia in southern chinese. three hundred and seventy women with cervical neoplasia (43 cervical intraepithelial neoplasia grade ii, 154 grade iii, and 173 invasive cancers) and 3 ... | 2007 | 17516530 |
| patients with malignant or pre-malignant cervical lesion have increased risk of becoming hepatitis b carrier. | human papillomavirus (hpv) and hepatitis b virus (hbv) are known aetiology of cervical and hepatocellular carcinoma, respectively. both diseases share a similar clinical course, that is, the vast majority of those infected by these two viruses can eradicate the viruses spontaneously. a small sub-group who fails to clear the virus becomes chronic carrier and can progress to carcinoma many years later. we postulated that patients with pre-malignant or malignant cervical lesion are at increased ris ... | 2007 | 17550135 |
| women's attitudes on human papillomavirus vaccination to their daughters. | this study assessed the impact of an information pamphlet on acceptance of human papillomavirus (hpv) vaccine in chinese women. the pamphlet increased the self-perceived knowledge on cervical cancer and hpv of the study subjects and had a positive influence on women accepting hpv vaccination for their daughters (p < .001). | 2007 | 17659226 |
| the potential impact of a prophylactic vaccine for human papillomavirus on the current cervical screening programme in hong kong. | to review and summarise current controversies in cervical screening in hong kong and discuss the potential impact of prophylactic human papillomavirus vaccination. | 2007 | 17664535 |
| profile of viral load, integration, and e2 gene disruption of hpv58 in normal cervix and cervical neoplasia. | the clinical utility of viral-load and integration status of human papillomavirus (hpv) infection remains uncertain. we examined 75 women infected with hpv58, a worldwide rare type found to be prevalent in cervical cancers in eastern asia. viral load was significantly higher for cervical intraepithelial neoplasia (cin) 1/2, but those for a normal control group and for cin 3 or cancer overlapped substantially. a pure integrated genome was found for all lesion grades, giving a poor positive predic ... | 2007 | 17703417 |
| beliefs about cervical cancer and human papillomavirus (hpv) and acceptability of hpv vaccination among chinese women in hong kong. | to assess the knowledge and beliefs on cervical cancer and hpv infection and to evaluate the acceptability of hpv vaccination among chinese women. | 2007 | 17707077 |
| barriers and facilitators to human papillomavirus vaccination among chinese adolescent girls in hong kong: a qualitative-quantitative study. | to explore perceptions towards cervical cancer, human papillomavirus (hpv) infection and hpv vaccination and to identify factors affecting the acceptability of hpv vaccination among chinese adolescent girls in hong kong. | 2008 | 18256106 |
| increase of integration events and infection loads of human papillomavirus type 52 with lesion severity from low-grade cervical lesion to invasive cancer. | infection load and the integration of human papillomaviruses (hpv) have been implicated as determinants for oncogenesis, but whether variation among different hpv types exists remains unclear. we investigated 91 women infected with hpv type 52 (hpv-52), a type that is rare worldwide but common in east asia. the median viral load increased with the severity of the lesion (248 copies/cell equivalent for normal/cervical intraepithelial neoplasia [cin] grade 1, 402 copies/cell equivalent for cin 2, ... | 2008 | 18272718 |
| epidemiology of human papillomavirus infection and cervical cancer and future perspectives in hong kong, singapore and taiwan. | hong kong, singapore and taiwan are three island states that are newly emerged affluent economic areas in asia. the majority of the populations are ethnically chinese with a total population of 6.98, 4.5 and 23 million, respectively. cervical cancer has been declining over the last thirty years in all three states and is largely attributable to widespread opportunistic cervical cancer screening. the age-standardized incidence rates of cervical cancer are 9.6 per 100,000 women in hong kong in 200 ... | 2008 | 18945415 |
| acceptability of human papillomavirus vaccination among chinese women: concerns and implications. | to explore chinese women's perceptions of human papillomavirus (hpv) vaccination and their intention to be vaccinated. | 2009 | 19250361 |
| distribution of human papillomavirus types in cervical cancers in hong kong: current situation and changes over the last decades. | human papillomavirus (hpv) type distribution among cervical cancers and its possible changes over time are key issues that determine the cost-effectiveness of hpv vaccines. cervical cancers diagnosed during 3 periods (1997-2007, n = 280; 1984-1986, n = 74; 1972-1973, n = 81) in hong kong were examined for hpv type distribution using sensitive broad-catching methods. the results showed a variation in hpv distribution between histological groups. among cervical squamous cell carcinoma (scc) cases ... | 2009 | 19507252 |
| acceptance of human papillomavirus vaccination among first year female university students in hong kong. | the present study assessed sexual behaviour, knowledge and attitudes among first year university students in order to identify factors that may affect their acceptance of human papillomavirus (hpv) vaccination. a cross-sectional survey was conducted at the chinese university of hong kong in august 2006. the survey was a self-administered questionnaire comprising questions regarding general health, sexual behaviour, knowledge about hpv and cervical cancer, and attitudes towards vaccination. chi2, ... | 2009 | 19917193 |
| de-stigmatising human papillomavirus in the context of cervical cancer: a randomised controlled trial. | to identify the components of a human papillomavirus (hpv) message contributing to reducing the stigma of hpv in cervical cancer. | 2010 | 20186874 |
| human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy chinese women from hong kong. | to assess the immunogenicity and safety of human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine in chinese women aged 18 to 35 years enrolled from hong kong. | 2010 | 20519752 |
| the effect of school-based cervical cancer education on perceptions towards human papillomavirus vaccination among hong kong chinese adolescent girls. | objective: to evaluate the effects of school-based cervical cancer education on hong kong chinese adolescent girls. methods: adolescent girls (n=953) in local secondary schools attended a tailored educational program on cervical cancer prevention. self-administered questionnaires were used before and after the program to measure its effects on participants' knowledge, attitude and perceived social norms towards human papillomavirus (hpv) vaccination and their intention to be hpv vaccinated. resu ... | 2010 | 20650592 |
| risk factors for cervical abnormalities among hong kong chinese women: a large-scale community-based cervical screening program. | we sought to identify the prevalence of and risk factors associated with cervical abnormalities among chinese women in hong kong. | 2010 | 21091197 |
| psychological burden of testing positive for high-risk human papillomavirus on women with atypical cervical cytology: a prospective study. | to assess the psychological burden of testing positive for high-risk human papillomavirus (hpv) on chinese women with atypical squamous cells of undetermined significance (ascus). | 2011 | 21306349 |
| prevalence and risk factors of human papillomavirus (hpv) infection in southern chinese women - a population-based study. | persistent high-risk type human papillomavirus (hpv) infection is recognized as a necessary cause of cervical cancer. this study aimed to compare the hpv prevalence and risk factors between women residing in hong kong (hk) and guangzhou (gz) region of china. | 2011 | 21559276 |
| prevalence of human papillomavirus, epstein-barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in hong kong patients. | background: the purpose of this study of human papillomavirus (hpv), epstein-barr virus (ebv), p21, and p53 in sinonasal inverted papilloma (ip) was to help elucidate its pathogenesis. methods: seventy-three ips, 48 nasal polyps, and 85 hypertrophied turbinates were subjected to hpv polymerase chain reaction (pcr) study. seventy-three ips, 30 nasal polyps, and 32 hypertrophied turbinates were subjected to ebv in situ hybridization (ish), p21, and p53 immunohistochemical (ihc) studies. results: h ... | 2011 | 21608063 |
| human papillomavirus vaccine: what are women most concerned about? | aim: this study aims to investigate the areas of concerns that women have regarding human papillomavirus (hpv) vaccination. material and methods: a cross-sectional questionnaire survey was conducted in a convenience sample of 1450 women attending outpatient family planning clinics in hong kong to assess women's concerns regarding hpv vaccination. the associations between each demographic characteristics and the importance of various issues concerning the vaccine, such as short and long-term si ... | 2011 | 21917074 |
| Assessment of knowledge and stigmatizing attitudes related to human papillomavirus among Hong Kong Chinese healthcare providers. | To assess knowledge and stigmatizing attitudes related to human papillomavirus (HPV) and HPV testing among Chinese healthcare providers in Hong Kong. | 2012 | 22036061 |
| a qualitative study on hpv vaccination from a nursing perspective in hong kong. | to identify the perception on human papillomavirus (hpv) vaccination among female nursing students in hong kong. | 2011 | 22320952 |
| cervical cancer prevention through cytologic and human papillomavirus dna screening in hong kong chinese women. | | 2011 | 21673355 |
| attitude, acceptability and knowledge of hpv vaccination among local university students in hong kong. | the human papillomavirus (hpv) vaccine has the great potential to prevent hpv-related infections for millions of women and men worldwide. however, the success of the vaccine is highly dependent on the vaccination rate. factors influencing the attitudes of undergraduate students towards hpv vaccination should be studied. this is a cross-sectional survey that was conducted to estimate the hpv vaccination rate among undergraduate students in hong kong, and to identify the predictors of their attitu ... | 2016 | 27187424 |
| the role of human papillomavirus in head and neck squamous cell carcinoma: a case control study on a southern chinese population. | hpv plays a role in the development of a portion of head and neck squamous cell carcinoma (hnscc), but only limited information on its role in southern chinese population is available. a multicenter case-control study was conducted. hpv type, viral integration, e6/7 mrna expression status, and tp53 mutation were determined. a total of 228 hnscc were recruited including 137 (60.1%) oral scc, 34 (14.9%) oropharyngeal scc, 31 (13.6%) laryngeal scc, 21 (9.2%) hypopharyngeal scc, and 5 (2.2%) lip and ... | 2016 | 26467027 |
| a home-school-doctor model to break the barriers for uptake of human papillomavirus vaccine. | a high coverage of human papillomavirus (hpv) vaccination is required to achieve a clinically significant reduction in disease burden. countries implementing free-of-charge national vaccination program for adolescent girls are still challenged by the sub-optimal uptake rate. voluntary on-site school-based mass vaccination programs have demonstrated high coverage. here, we tested whether this could be an option for countries without a government-supported vaccination program as in hong kong. | 2015 | 26392084 |
| cervical cancer prevention practices through screening and vaccination: a cross-sectional study among hong kong chinese women. | no published data are available that currently evaluate chinese adult women's cervical cancer prevention practices through screening and vaccination using population-based samples. this study describes patterns and correlates of these behaviors among hong kong chinese women aged 30-59 years. | 2015 | 26022528 |
| genomic aberrations in cervical adenocarcinomas in hong kong chinese women. | although the rates of cervical squamous cell carcinoma have been declining, the rates of cervical adenocarcinoma are increasing in some countries. outcomes for advanced cervical adenocarcinoma remain poor. precision mapping of genetic alterations in cervical adenocarcinoma may enable better selection of therapies and deliver improved outcomes when combined with new sequencing diagnostics. we present whole-exome sequencing results from 15 cervical adenocarcinomas and paired normal samples from ho ... | 2015 | 25626421 |
| editorial. dissemination reports related to influenza, viral hepatitis and human papillomavirus. | | 2014 | 25482961 |
| factors influencing adolescent girls' decision in initiation for human papillomavirus vaccination: a cross-sectional study in hong kong. | cervical cancer is one of the common cancers among women worldwide. despite hpv vaccination being one of the effective preventive measures, it is not included in government vaccination programme in hong kong. this study aimed to assess the knowledge of and attitude towards cervical cancer prevention among chinese adolescent girls in hong kong, and to identify factors influencing the initiation of hpv vaccination. | 2014 | 25195604 |
| perceptions of and barriers to vaccinating daughters against human papillomavirus (hpv) among mothers in hong kong. | significant others are noted to be remarkable influences in modelling children's and young people's health perceptions and their adoption of health behaviour. the vaccinations which a child receives are shown to be significantly influenced by his or her parents. however, there is a paucity of chinese-based studies. when discussing the human papillomavirus (hpv) vaccine, very few studies examine the perceptions of chinese parents regarding the vaccine as a preventive health measure, and even fewe ... | 2014 | 24890226 |
| hpv vaccination in hong kong: uptake and reasons for non-vaccination amongst chinese adolescent girls. | the study aims to determine hpv vaccine uptake (≥ 1 dose) amongst adolescent girls in hong kong and to explore the reasons for non-acceptance of the vaccine. | 2013 | 24148571 |
| knowledge, attitude, practice and barriers on vaccination against human papillomavirus infection: a cross-sectional study among primary care physicians in hong kong. | this study explored the knowledge, attitude, practice and barriers to prescribe human papillomavirus (hpv) vaccines among private primary care physicians in hong kong. a self-administered questionnaire survey was conducted by sending letters to doctors who had joined a vaccination program for school girls. from 720 surveys sent, 444 (61.7%) completed questionnaires were returned and analyzed. for knowledge, few responded to questions accurately on the prevalence of cervical hpv (27.9%) and genit ... | 2013 | 23990994 |
| barriers to receiving human papillomavirus vaccination among female students in a university in hong kong. | this paper investigates, using a qualitative approach, barriers to receiving human papillomavirus (hpv) vaccine among female undergraduate students in a hong kong university. by conducting individual semi-structured interviews with 35 young women aged 19 to 23, seven intertwining perceptual, social and cultural, healthcare provider and financial barriers were identified. these barriers included the perception as being low-risk due to an absence of sexual contact, lack of confidence in the safety ... | 2013 | 23826650 |
| transvaginal ultrasound probe contamination by the human papillomavirus in the emergency department. | to determine if human papillomavirus (hpv) dna can be detected on the transvaginal sonography (tvs) probe in the emergency department (ed) and whether the current barrier method plus disinfection can prevent hpv contamination of the tvs probe. | 2013 | 22761513 |
| comparison of the genoflow human papillomavirus (hpv) test and the linear array assay for hpv screening in an asian population. | high-risk human papillomavirus (hr-hpv) dna detection in cervical cytology samples is useful for primary screening of cervical cancer and for triage of patients with equivocal cytological findings. the genoflow hpv array test (gf assay; diagcor bioscience inc., hong kong) was recently developed to detect 33 hpv genotypes by a "flowthrough" hybridization technology. in this study, we assessed the analytical sensitivity and reproducibility of the gf assay and compared its genotyping results with t ... | 2012 | 22337983 |
| facilitators and barriers to the acceptance of human papillomavirus (hpv) vaccination among adolescent girls: a comparison between mothers and their adolescent daughters in hong kong. | the aim of this study is to examine knowledge and attitude as facilitators and barriers to the acceptance of hpv vaccination for adolescent girls by mothers and adolescent girls. | 2017 | 28797277 |
| determinants of human papillomavirus vaccination uptake among adolescent girls: a theory-based longitudinal study among hong kong chinese parents. | human papillomavirus (hpv) vaccination uptake among chinese adolescent girls remains extremely low. this two-year longitudinal study examined theoretical predictors of adolescent girls' hpv vaccination uptake using an extended theory of planned behaviour (tpb). between february and november 2014, a random sample of 1996 (response rate 60%) hong kong chinese parents of 12- to 17-year-old hpv unvaccinated girls completed baseline telephone interviews assessing attitudes and intention towards hpv v ... | 2017 | 28652087 |