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human papillomavirus genotypes associated with cervical cytologic abnormalities and hiv infection in ugandan women.human papillomavirus (hpv) infection is associated with almost all cases of cervical cancer, and cervical cancer is a common malignancy in women living in developing countries. a cross-sectional study was conducted to determine the prevalence of hpv infection, human immunodeficiency virus (hiv) infection, and cervical cytologic abnormalities in women presenting to a sexually transmitted infections clinic in kampala, uganda. in june and july, 2002, 135 women underwent complete physical exams incl ...200717457908
infection with human papillomavirus and hiv among young women in kampala, uganda.information on the prevalence of cervical infection with different human papillomavirus (hpv) types among young women is essential to support the introduction of hpv vaccine in uganda.200818237268
prevalence and risk factors for carcinogenic human papillomavirus infections in rural rakai, uganda.to investigate self-administered vaginal swabs for assessing prevalence and correlates of carcinogenic human papillomavirus (hpv) infection in rural rakai, uganda.200818385223
a case-control study of cancer of the uterine cervix in uganda.as part of an epidemiological study of cancer in uganda, we investigated social, sexual and reproductive factors in relation to the risk of cancer of the uterine cervix. patients with all cancer types or with benign tumours were recruited from hospitals in kampala, uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against the human immunodeficiency virus-1 (hiv). the case-control study reported here involves 702 hiv-seronegative women, 343 of whom were ...200718090129
comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in rakai, uganda.the objective of this study was to compare human papillomavirus (hpv) dna testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural rakai district, uganda.200717075437
carcinoma of the conjunctiva and hiv infection in uganda and malawi.to investigate the association of human immunodeficiency virus (hiv) infection and carcinoma of the conjunctiva in africa, and the role of human papilloma virus type 16 (hpv-16).19968759259
multiple infections in cases of cervical cancer from a high-incidence area in tropical africa.the presence of several infections was determined in tissue and serum samples from 34 cases and 23 controls seen in 1984-85 at mulago hospital in kampala, uganda. when assessing single infections, association with cervical cancer could be shown for 5 agents, namely by southern blot assay for human papillomavirus types 16 and 18 (hpv), and by serological tests at varying levels of antibody titres, for herpes simplex virus type i and/or 2 (hsv), cytomegalovirus (cmv), epstein-barr virus, viral cap ...19892714885
circumcision of hiv-infected men and transmission of human papillomavirus to female partners: analyses of data from a randomised trial in rakai, uganda.background: male circumcision reduces the transmission of high-risk human papillomavirus (hpv) in hiv-uninfected men and their female partners. we assessed whether circumcision of hiv-infected men would reduce the transmission of high-risk hpv to their female partners. methods: female partners of hiv-infected men (aged 15-49 years) in rakai, uganda, with cd4 counts of greater than 350 cells per ml who were randomly assigned to undergo circumcision immediately (intervention group) and after 24 mo ...201121489882
male circumcision and anatomic sites of penile high-risk human papillomavirus in rakai, uganda.male circumcision (mc) reduces penile high-risk human papillomavirus (hr-hpv) on the coronal sulcus and urethra. hr-hpv varies by anatomic site, and it is unknown whether mc decreases hr-hpv on the penile shaft. we assessed the efficacy of mc to reduce hr-hpv on the penile shaft and compared it to known efficacy of mc to reduce hr-hpv on the coronal sulcus. hiv-negative men randomized to receive immediate circumcision (intervention) or circumcision delayed for 24 months (control) were evaluated ...201121462185
a modeling framework for the analysis of hpv incidence and persistence: a semi-parametric approach for clustered binary longitudinal data analysis.human papillomavirus (hpv) infection is a common sexually transmitted disease of growing public health importance, and over 40 genotypes have been identified in genital infections. current hpv cohort studies often follow participants at pre-determined visits, such as every 6 months, and data generated from such epidemiology studies can be described as clustered longitudinal binary data where correlation arises in two ways: the directionless clustering due to the multiple genotypes tested within ...201020839368
parametric frailty models for clustered data with arbitrary censoring: application to effect of male circumcision on hpv clearance.in epidemiological studies, subjects are often followed for a period during which study outcomes are measured at selected time points, such as by diagnostic testing performed on biological samples collected at each visit. although test results may indicate the presence or absence of a disease or condition, they cannot provide information on when exactly it occurred. such study designs generate arbitrarily censored time-to-event data, which can include left, interval and right censoring. adding t ...201020459614
male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in hiv-negative men: a randomized trial in rakai, uganda.uncircumcised human immunodeficiency virus (hiv)-negative men aged 15-49 years were randomized to immediate circumcision (intervention arm, 441 subjects) or delayed circumcision (control arm, 399 subjects). human papillomavirus (hpv) was detected by roche hpv linear array at enrollment, and at 6, 12, and 24 months. incident high-risk hpv (hr-hpv) was estimated in men who acquired a new hr-hpv genotype. hr-hpv clearance was determined in men with prior genotype-specific hr-hpv infections. rate ra ...201020370483
circumcision of hiv-infected men: effects on high-risk human papillomavirus infections in a randomized trial in rakai, uganda.in rakai, uganda, human immunodeficiency virus (hiv)-positive men were randomized to undergo either immediate circumcision (intervention arm) or delayed circumcision (control arm). penile swab samples were assayed for high-risk human papillomavirus (hr-hpv) by roche hpv linear array at enrollment and at 24 months (intervention arm, 103 subjects; control arm, 107 subjects). rate ratios (rrs) of hr-hpv were estimated by poisson regression. at 24 months, hr-hpv prevalence was found in 57 (55.3%) of ...201020370481
human papillomavirus prevalence and cytopathology correlation in young ugandan women using a low-cost liquid-based pap preparation.screening for hpv-driven cervical dysplasia and neoplasia is a significant public health concern in the developing world. the purpose of this study was to use a manual, low-cost liquid-based pap preparation to determine hpv prevalence in hiv-positive and hiv-negative young women in kampala, uganda and to correlate cervical cytopathology with hpv-dna genotype. about 196 post-partum women aged 18-30 years underwent rapid hiv testing and pelvic examination. liquid-based cervical cytology samples we ...201019937939
prevalence, incidence and clearance of human papillomavirus infection among young primiparous pregnant women in kampala, uganda.the proportion of women who have already been exposed to human papillomavirus (hpv) infection by the time they first become pregnant, and the influence of pregnancy and delivery on the course of hpv infection are unclear. in kampala, uganda, 987 young primiparous pregnant women aged <25 years had gynaecological examination and liquid-based cytology. in the follow-up, women acted as their own controls, i.e., 1st/2nd versus 3rd trimesters (105 women), and during pregnancy versus after delivery (28 ...200818711697
human papillomavirus type distribution in invasive cervical cancer in uganda.we conducted a study aiming to describe human papillomavirus (hpv) type distribution in invasive cervical carcinoma in uganda.200818577214
determinants of incidence and clearance of high-risk human papillomavirus infections in rural rakai, uganda.we used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (hpv) infections in rural rakai, uganda.200818559545
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