phenotypical and genotypical characterization of bordetella pertussis strains isolated in são paulo, brazil, 1988-2002.whooping cough or pertussis was a major cause of childhood morbidity and mortality in the world until the introduction of a whole-cell vaccine in the 1940's. however, since the early 1980's whooping cough cases have increased in many countries, becoming an important problem of public health. this increase may be due to accuracy of laboratory diagnosis and reporting of the disease, a decline in immunity over time, demographic changes, and adaptation of the bacterial population to vaccine-induced ...200717505674
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