Publications

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epidemiology of genital herpes.new serological methods, based on the detection of type-specific antibodies to herpes simplex virus (hsv) glycoproteins, have allowed a reappraisal of the prevalence of genital herpes. during the 1980s, genital herpes continued to be an infection of epidemic proportions in many developed countries. in the usa, although there was evidence of a decline in the age-specific prevalence of hsv type 1 (hsv-1) infection, the seroprevalence of hsv type 2 (hsv-2) has continued to increase. among those att ...19948063020
serologic evidence of human herpesvirus 8 transmission by homosexual but not heterosexual sex.epidemiologic studies link kaposi's sarcoma with a sexually transmitted agent. human herpesvirus 8 (hhv-8) is likely to be that agent, but routes of transmission are poorly described. a seroepidemiologic study was conducted to determine whether hhv-8 is transmitted sexually between heterosexuals. sera from 2718 patients attending a sexually transmitted disease (std) clinic were tested for antibodies to hhv-8 and herpes simplex virus type 2 (hsv-2). information on sex partners in the previous 12 ...199910438345
the burden of infection with hsv-1 and hsv-2 in england and wales: implications for the changing epidemiology of genital herpes.to measure the burden of infection with herpes simplex type 1 (hsv-1) and herpes simplex type 2 (hsv-2) in the general population of england and wales and to assess temporal changes in the incidence of hsv-1 infection in childhood.200010961195
national survey of diagnostic services for genital herpes.to investigate the provision of diagnostic services for genital herpes simplex virus (hsv) infection in the united kingdom.200516061538
relationship between antibodies to herpes simplex virus (hsv) and symptoms of hsv infection.to determine the relationship between antibodies to herpes simplex virus (hsv) types 1 and 2 and diagnosis of orolabial and genital herpes, a cross-sectional survey was done among 869 sexually transmitted disease clinic attendees and 1594 blood donors in london. among clinic attenders, the prevalence of hsv-1 infection was 59.5% and that of hsv-2 infection was 22.7%, and among blood donors the prevalence was 44.6% and 7.6%, respectively. the sensitivity and specificity of a diagnosis of oral her ...19968769602
a comparison of referral patterns and characteristics of patients with first episode symptomatic genital hsv-1 and hsv-2 infections in sheffield.to ascertain factors associated with hsv-1 and hsv-2 isolates in patients attending a genitourinary medicine clinic with symptomatic first episode genital herpes (fegh).19968707325
apparent increase in the prevalence of herpes simplex virus type 1 genital infections among women. 19948039792
antibody to herpes simplex virus type 2 as serological marker of sexual lifestyle in populations.to examine the epidemiology of antibody to herpes simplex virus type 2 and to assess its suitability as a serological marker of sexual behaviour in populations with high and low prevalences.19947866079
epidemiology of herpes simplex virus types 2 and 1 amongst men who have sex with men attending sexual health clinics in england and wales: implications for hiv prevention and management.the objective was to investigate herpes simplex virus (hsv) epidemiology amongst hiv-positive and hiv-negative men who have sex with men (msm) in england and wales. unlinked anonymous sera from 3,968 msm attending 12 sexual health clinics in 2003 were tested for hiv, hsv-2 and hsv-1 antibodies. fifty-five percent of hiv-positive msm were hsv-2-seropositive, compared to 17% of hiv-negative msm (adj rr: 2.14 [ci: 1.92-2.37]). amongst hiv-positive individuals, there was no significant difference in ...200919941804
seroprevalence of herpes simplex virus type 2 in multiple sclerosis.it has been proposed that multiple sclerosis (ms) might be a sexually transmitted disorder. there is evidence that seropositivity to herpes simplex virus type 2 (hsv-2) correlates well with the number of sexual partners. accordingly, a raised overall hsv-2 seroprevalence in ms would lend support to this theory.200617083334
how safe is safer sex? high levels of hsv-1 and hsv-2 in female sex workers in london.female sex workers in europe have low levels of sexually transmitted infections, attributable to condom use. the aim of this paper is to describe the seroepidemiology of hsv-1 and hsv-2 in female sex workers in london by using a 15-year prospective study of 453 sex workers. the seroprevalence of hsv-1 was 74.4% and independently associated with birth in a 'transitional country' (or 5.4, 95% ci 1.61-18.20). the seroprevalence of hsv-2 was 60% and declined over time; it was also independently asso ...200616569273
the epidemiology of genital infection with herpes simplex virus types 1 and 2 in genitourinary medicine attendees in inner london.to characterise the epidemiological and clinical features of genital herpes and the diagnostic role of hsv-2 specific serology in an ethnically diverse cohort of genitourinary medicine (gum) attendees in inner london.200516061536
new estimates of herpes simplex virus type 2 seroprevalence in england: 'high' but stable seroprevalence over the last decade.there have been few recent population-based herpes simplex virus type 2 (hsv-2) seroprevalence studies in england, but reports from the united states have indicated a 30% rise in hsv-2 seroprevalence between 1976 and 1994. this study aimed to ascertain trends in hsv-2 infection in england between 1991 and 2000.200415028940
prevalence of hsv-1/hsv-2 antibodies in hiv seropositive patients in coventry, united kingdom. 200414755048
the acceptability of the introduction of a type specific herpes antibody screening test into a genitourinary medicine clinic in the united kingdom.to determine the uptake of a type specific herpes simplex antibody test if it were offered as part of routine screening in a genitourinary medicine clinic in a district general hospital in the united kingdom.200312690134
genital herpes serotesting: a study of the epidemiology and patients' knowledge and attitude among std clinic attenders in coventry, uk.to examine the seroprevalence and correlates of antibodies to herpes simplex viruses type 1 (hsv-1) and type 2 (hsv-2), and to assess patients' knowledge and attitude towards genital herpes infection and its serotesting, before and after counselling.200312576612
ethnic variation in type of genital herpes simplex virus infection in a south london genitourinary medicine clinic.the aims of this study were to investigate the prevalence of herpes simplex virus (hsv) types 1 and 2 in the study population and correlate the results with clinical and demographic details. consecutive hsv isolates from 334 clinic attendees were typed by immunofluorescence. patient information was collected from the case notes. overall, hsv-1 was isolated from 48 and hsv-2 from 287 samples, respectively. there was no significant difference in isolation rates according to gender. however, 33% of ...200312436485
seroprevalence of antibodies to herpes simplex virus types 1 and 2 among two sexually active female populations in middlesbrough, england.herpes simplex virus (hsv) infection occurs worldwide but its epidemiology varies between different countries and between groups of individuals. seroprevalence of hsv-1 and hsv-2 antibodies is a more accurate method of determining epidemiology of this infection. in this cross-sectional study, 467 blood samples were obtained from women attending the genitourinary medicine clinic (gum) and antenatal clinic (anc) in middlesbrough, england. analysis of their blood samples showed that 69.5% gum patie ...200212134761
sero-epidemiological patterns of epstein-barr and herpes simplex (hsv-1 and hsv-2) viruses in england and wales.the aim was to carry out a population-based sero-prevalence survey of epstein-barr virus (ebv) across a wide age range in england and wales and to identify any associations between ebv and herpes simplex virus types one and two (hsv-1 and 2). sera from an age-stratified sample of 2,893 individuals, submitted for diagnostic purposes to 15 public health laboratories in england and wales in 1994, were tested for immunoglobulin g (igg) antibody to ebv. the samples had been tested previously for igg ...200212115998
serological prevalence of herpes simplex virus type 2 amongst gum clinic attenders in a district general hospital setting.our objective was to determine the seroprevalence of herpes simplex virus (hsv) type 2 infection amongst genitourinary medicine (gum) clinic attenders at a district general hospital using a commercially available enzyme immunoassay (eia). in a prospective study, heterosexual patients attending the department of gum at trafford general hospital attending with a new clinical problem and having a blood sample taken for routine syphilis serology had the same sample tested for hsv type 2 antibodies. ...200010872911
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