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cancer survival in khon kaen province, thailand.thailand is one of the few developing countries for which population-based cancer survival data are available. using clinical follow-up information and reply-paid postal enquiries, 10,333 residents of khon kaen province registered with cancer in the period 1985-1992 were followed-up to the end of 1993. the sites of the most common cancers in the province were liver (5-year relative survival rate 9.2%), cervix (60.1%), lung (15.4%), breast (48.1%) and large bowel (41.9%). results for khon kaen we ...19957729937
parasite-associated morbidity: liver fluke infection and bile duct cancer in northeast thailand.infection with the liver fluke, opisthorchis viverrini, remains a major public health problem in northeast thailand, where approximately one-third of the population is infected. the northeast region is largely populated by laos-descendent thais who enjoy eating raw fish, which harbour the infective stage of the fluke. the parasite has maintained its presence in the population despite the widespread use of praziquantel and dissemination of health education material throughout the region by vigoro ...19947982745
promotion of the health of rural women towards safe motherhood--an intervention project in northeast thailand.an intervention project focusing on the health of women in the reproductive age was conducted in three districts of khon kaen province, northeast thailand between 1991 and 1996. main emphasis was placed on improving reproductive health, the nutritional status including the iron deficiency anemia (ida) as well as iodine deficiency disorders (idd), and the parasitic diseases liver fluke (opisthorchis viverrini) and hookworm. for implementation a community based primary health care approach was use ...200011488446
prevalence of opisthorchis viverrini infection and incidence of cholangiocarcinoma in khon kaen, northeast thailand.liver cancer is the most common cancer in khon kaen, northeast thailand, because of the high incidence of cholangiocarcinoma (chca). opisthorchis viverrini (ov), a liver fluke, is endemic in the area, and has been evaluated as a cause of chca by international agency for research on cancer. residents of 20 districts in the province were invited to attend a mobile screening programme between 1990 and 2001. of 24 723 participants, 18 393 aged 35-69 years were tested for ov infection, by examining s ...200415117303
a prospective study of diet, lifestyle, and genetic factors and the risk of cancer in khon kaen province, northeast thailand: description of the cohort.cohort studies are the preferred design in observational epidemiology, but few involving the general population have been performed in asia, and most concern affluent urban populations. the khon kaen study has recruited about 25,000 subjects, aged mainly 35-64, from villages in the relatively underdeveloped north-east of thailand. all subjects underwent simple physical examination, completed an interviewer-administered questionnaire (including sections on lifestyle, habits, and diet) and donated ...200516235989
detection of opportunistic and non-opportunistic intestinal parasites and liver flukes in hiv-positive and hiv-negative subjects.we assessed the frequency and distribution of infection with opportunistic and non-opportunistic intestinal parasites and the liver fluke, opisthorchis viverrini, in hiv-seropositive and hiv-seronegative subjects. age- and sex-matched hiv-seropositive (n = 78) and hiv-seronegative patients (n = 78) from two hospitals in khon kaen province, thailand, participated in this study from november 1998 to august 2000. these subjects were divided according to the presence of diarrhea and cd4 counts. a si ...200516295534
ultrasound screening for opisthorchis viverrini-associated cholangiocarcinomas: experience in an endemic area.in thailand, liver cancer is the most common malignancy in males and the third most common among females. in the northeast region, cholangiocarcinoma (chca) is the prevalent type, with opisthorchis viverrini (ov), an endemic liver fluke, being considered the cause. we evaluated the role of ultrasound (u/s) for cholangiocarcinoma screening as part of a larger cohort to characterize the linkage between liver fluke infestation and chca in khon kaen (northeast thailand). most people (77%) had normal ...200617059338
Diagnostic values of parasite-specific antibody detections in saliva and urine in comparison with serum in opisthorchiasis.Infection by the liver fluke (Opisthorchis viverrini) causes hepatobiliary disease and bile duct cancer (cholangiocarcinoma, CCA) in endemic areas in Southeast Asia. Measurements of humoral immune response particularly parasite-specific antibodies are useful not only for serodiagnosis but they have been implicated as risk factors of CCA. In this study, we used indirect Enzyme Immunosorbent Assay (ELISA) to measure O. viverrini-specific immunoglobulins in serum, urine and saliva and assessed effi ...201121704727
Fecal bacterial contamination in natural water reservoirs as an indicator of seasonal infection by Opisthorchis viverrini in snail intermediate hosts.Opisthorchis viverrini, a carcinogenic liver fluke, requires Bithynia snails as the first intermediate host, which release cercariae after ingesting fluke eggs from contaminated water. Fecal bacterial contamination and O. viverrini-infected Bithynia snails were investigated in samples collected from natural water reservoirs in Ban Phai, Chonnabot and Muang Districts (Ban Lerngpeuy) in Khon Kaen Province, northeast Thailand, where there is a high incidence of cholangiocarcinoma. Water was sampled ...201221871971
a cross-sectional study on the potential transmission of the carcinogenic liver fluke opisthorchis viverrini and other fishborne zoonotic trematodes by aquaculture fish.throughout southeast asia and china, eating raw and or partially cooked cyprinid fish causes liver (hepatobiliary) disease and cancer (cholangiocarcinoma) due to fishborne zoonotic trematodes (fzt), in particular clonorchis sinensis and opisthorchis viverrini. the primary source of transmission is by native fish, but aquaculture fish are also reported to have high infective potential. here, a cross-sectional survey of fzt in fish farms was conducted in an endemic area in khon kaen province, thai ...201323320421
roles of liver fluke infection as risk factor for cholangiocarcinoma.several factors are known to be associated with risk of cholangiocarcinoma (cca) and infection with the liver flukes, opisthorchis viverrini and clonorchis sinensis, has often been singled out as the leading risk factor in east and southeast asia. in this review, current knowledge of their biology, life cycle, and pathogenesis of o. viverrini, and its role as a carcinogenic parasite are presented. the trends of age-specific incidence of liver cancer in khon kaen, northeast thailand are considere ...201424408775
role of socio-cultural and economic factors in cyprinid fish distribution networks and consumption in lawa lake region, northeast thailand: novel perspectives on opisthorchis viverrini transmission dynamics.opisthorchis viverrini (ov) is a fish-borne parasite endemic in parts of lao pdr, cambodia, southern vietnam and northeast thailand (isaan) where an estimated 10 million people are infected. human ov infection, associated with hepatobiliary complications, including cholangiocarcinoma (cca), occurs when infected fish are consumed raw or undercooked, a longstanding cultural tradition in the region. this mixed- methods descriptive study was carried out in isaan villages around lawa lake, khon kaen ...201728216369
the lawa model: a sustainable, integrated opisthorchiasis control program using the ecohealth approach in the lawa lake region of thailand.opisthorchiasis caused by the carcinogenic liver fluke opisthorchis viverrini is a major foodborne parasitic zoonotic disease in thailand and neighboring mekong countries. the infection is associated with several hepatobiliary diseases including cholangiocarcinoma (cca). the rates of cca in regions where the parasite is endemic are unprecedented. extensive research on various aspects of opisthorchiasis has been conducted in recent decades. however, the current status of o. viverrini infection in ...201627890720
association between opisthorchis viverrini and leptospira spp. infection in endemic northeast thailand.opisthorchiasis caused by opisthorchis viverrini is an important foodborne trematodiasis in thailand, laos and cambodia. interestingly, the opisthorchiasis endemic region overlaps with an area of leptospirosis emergence. here we report an association between opisthorchiasis and leptospirosis in thailand. of 280 sera collected from villagers living around the lawa wetland complex in khon kaen province, 199 (71%) were seropositive for leptospirosis by immunochromatography. individuals with o. vive ...201627746382
assessing the role of landscape connectivity on opisthorchis viverrini transmission dynamics.opisthorchis viverrini (ov) is one of the most important human parasitic diseases in southeast asia. although the concept of connectivity is widely used to comprehend disease dispersal, knowledge of the influences of landscape connectivity on ov transmission is still rudimentary. this study aimed to investigate the role of landscape connectivity in ov transmission between the human and the first intermediate snail hosts. fieldwork was conducted in three villages respectively in kamalasai distric ...201627265875
community-based health education and communication model development for opisthorchiasis prevention in a high risk area, khon kaen province, thailand.this study aimed to evaluate the impact of a community-based health education and communication programme on reducing liver fluke infections caused by the consumption of uncooked fish among people in a high-risk area of thailand.201526625799
pathological characteristics of intraductal polypoid neoplasms of bile ducts in thailand.intraductal papillary or tubular neoplasms of the bile duct have recently been proposed as one of the pre-invasive lesions of cholangiocarcinoma. herein, a total of 50 cases of intraluminal polypoid neoplasms of the bile ducts experienced in khon kaen university hospital in thailand were pathologically examined. these cases presumably had a history of infection of opisthorchis viverrini. these neoplasms were histologically composed of high-grade intraepithelial neoplasm showing a tubular and/pap ...201526339398
cohort profile: cholangiocarcinoma screening and care program (cascap).cholangiocarcinoma (cca) is an extremely aggressive cancer that is usually fatal. although globally morbidity and mortality are increasing, knowledge of the disease remains limited. the mekong region of southeast asia, and particularly the northeast of thailand, has by far the highest incidence of cca worldwide with 135.4 per 100,000 among males and 43.0 per 100,000 among females being reported in khon kaen province. most patients are first seen during late stage disease with 5-year survival bei ...201526054405
trematode diversity in the freshwater snail bithynia siamensis goniomphalos sensu lato from thailand and lao pdr.in order to obtain a comprehensive understanding of trematode diversity in bithynia siamensis goniomphalos sensu lato, the first intermediate host of the liver fluke opisthorchis viverrini s.l., the prevalence of larval trematode species was investigated in different localities in thailand and lao people's democratic republic (lao pdr). in thailand, snail samples were collected from 29 localities in the nine provinces: buri ram, surin, chaiya phum, maha sarakham, khon kaen, kalasin, mukdahan, sa ...201625997613
toward integrated opisthorchiasis control in northeast thailand: the lawa project.human liver fluke, opisthorchis viverrini, a food-borne trematode is a significant public health problem in southeast asia, particularly in thailand. despite a long history of control programmes in thailand and a nationwide reduction, o. viverrini infection prevalence remains high in the northeastern provinces. therefore, a new strategy for controlling the liver fluke infection using the ecohealth/one health approach was introduced into the lawa lake area in khon kaen province where the liver fl ...201525102053
an ecological study of bithynia snails, the first intermediate host of opisthorchis viverrini in northeast thailand.infection with the food-borne trematodiasis, liver fluke opisthorchis viverrini, is a major public health concern in southeast asia. while epidemiology and parasitic incidence in humans are well studied, ecological information on the o. viverrini intermediate hosts remains limited. this study aimed to investigate the factors affecting the distribution and abundance of the first intermediate host, bithynia siamensis goniomphalos snails. water quality and snails were sampled in 31 sites in muang d ...201524561073
prevalence and co-infection of intestinal parasites among thai rural residents at high-risk of developing cholangiocarcinoma: a cross-sectional study in a prospective cohort study.intestinal parasitic infections (ipis) are still important to the health of thai rural residents. ipis are the cause of many chronic diseases with, for example, opisthorchiasis resulting in progression to cholangiocarcinoma (cca). this cross-sectional study in a prospective cohort study aimed to examine the prevalence and co- infection of intestinal parasites among northeastern thai rural residents, recruited into the khon kaen cohort study (kkcs), and who were residing in areas of high-risk for ...201223464426
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