| etiology of sporadic aseptic meningitis in children in the leningrad area. | the etiology of sporadic aseptic meningitis among children in the leningrad area in 1974 was studied. 184 patients and 284 healthy children of the same age groups were studied; altogether 540 stool specimens and 99 cerebrospinal fluid specimens were collected for virus isolations and 162 pairs of sera for virus antibody assays. mumps virus infection was the etiology of the disease only in 5% of cases. the main etiological role of enteroviruses was proved. strains most often associated with disea ... | 1979 | 223233 |
| [testing for the safety, reactogenicity and antigenic properties of a live thermostable mumps vaccine made from the leningrad-3 strain]. | a live mumps vaccine (lmv) from strain leningrad-3 with a new stabilizer ls-18 was tested for reactogenicity and antigenic potency. examinations of vaccinated children for vaccination reactions showed its complete areactogenicity and safety. lmv induced synthesis of virus-neutralizing antibodies in 78-82% of the vaccinees. determinations of the dynamics, intensity and duration of circulation of specific antihemagglutinating, antineuraminidase and virus-neutralizing antibodies demonstrated marked ... | 1991 | 1796587 |
| [a virological description of serous meningitis in children immunized with vaccine against epidemic parotitis]. | the morbidity structure was analyzed in children vaccinated against epidemic parotitis in 1993-2002. eight children (4 with serous meningitis and 4 with lesions of the salivary glands) underwent virologic and immunologic examinations. the molecular typing of the sh-gene fragment of the parotitis virus showed the process in 7 cases to be provoked by the vaccination strain. presumedly, progressing vaccine-associated meningitis inhibits antibody formation. the total incidence of vaccine-associated ... | 2004 | 15529861 |
| mumps vaccine failure investigation in novosibirsk, russia, 2002-2004. | the aims of this study were to estimate the importance of vaccine failure (vf) in cases of mumps during 2002-2004 in the city of novosibirsk, western siberia, russia, and to genotype the responsible virus strain. mumps virus-specific rt-pcr testing of saliva was performed for 18 cases of mumps. sera were tested for igm and igg, igg avidity, and the ability to neutralise a panel of mumps viruses, including the leningrad-3 mumps vaccine virus. of the 12 patients for whom vaccination status was pos ... | 2007 | 17484765 |
| [virus strain specific serum neutralizing antibodies in children and adolescents immunized with a russian mumps vaccine]. | postvaccination immunity was studied in the children and teenagers without a history of clinical mumps infection, who had been immunized with the leningrad-3 mumps vaccine. the level of specific lgg in elisa and that and spectrum of their neutralizing activity against a vaccine strain and three heterologous mumps virus (mv) strains (genotypes a, c, and h) were measured. the investigation included 151 sera from the vaccinees aged 3 to 17 years, possessing the detectable specific igg titers in eli ... | 2010 | 21381334 |
| [specific humoral immunity after single immunization with mumps vaccine: data of a 3-year follow-up]. | the level and spectrum of humoral specific immunity were studied in 60 volunteers immunized with russian mumps vaccine. specific igg levels were measured by enzyme immunoassay (eia) and neutralization test using the leningrad-3 (l-3) mumps virus (mv) vaccine strain and 5 heterologous mv strains of various genotypes (a, b, c, d, and h). the maximum functional activity of antibodies was recorded at an average of 18 months postvaccination. within 3 years after vaccination, starting at 6 months, spe ... | 2011 | 21786628 |
| [comparative evaluation of leningrad-3 mumps vaccine virus neurovirulence in a neonatal rat model]. | the neurovirulence and replication potential of several mumps virus strains, including leningrad-3 mumps vaccine virus (fsue sic "microgen", russia) and wild type strains isolated in the novosibirsk region (russia), were assessed in rat tests. the mean neurovirulence scores of the leningrad-3 virus (< 4.0) were significantly lower than those of wild type strains (ranging from 6.1 to 15.2) and were in accordance with the scores determined for other attenuated mumps vaccine strains (usually rangin ... | 2011 | 21899067 |