Publications

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in vitro activity of meropenem against common pathogenic bacteria isolated in taiwan.the in vitro antimicrobial activity of meropenem, in comparison with nine other antimicrobial agents, against 12 different common pathogenic bacteria were evaluated to know the susceptibility of common bacteria to meropenem in taiwan. meropenem was active against most gram-positive, gram-negative, and anaerobic bacteria, including methicillin-sensitive staphylococcus aureus, streptococcus pyogenes, enterococcus faecalis, escherichia coli, klebsiella pneumoniae, enterobacter cloacae, pseudomonas ...19989934544
relationships between antimicrobial use and antimicrobial resistance in gram-negative bacteria causing nosocomial infections from 1991-2003 at a university hospital in taiwan.this study was conducted to evaluate the relationship between antimicrobial resistance and antimicrobial use in a university hospital in taiwan. disk susceptibility data of escherichia coli, klebsiella pneumoniae, enterobacter cloacae, serratia marcescens, proteus spp., pseudomonas aeruginosa, acinetobacter spp., stenotrophomonas maltophilia and other non-fermentative gram-negative bacilli causing nosocomial infections were evaluated. data on annual patient-days and annual consumption (defined d ...200516280243
in vitro activity of isepamicin and other aminoglycosides against clinical isolates of gram-negative bacteria causing nosocomial bloodstream infections.isepamicin is a newly introduced aminoglycoside in taiwan. since in vitro data for isepamicin against nosocomial gram-negative bloodstream infection from taiwan are limited, we compared the activity of isepamicin, amikacin, gentamicin and tobramycin against nosocomial gram-negative blood isolates.200718087627
association between contaminated faucets and colonization or infection by nonfermenting gram-negative bacteria in intensive care units in taiwan.this study was designed to determine the strength of the association between the isolation of nonfermentative gram-negative bacilli (nfgnb) from tap water faucet aerators and the prevalence of colonization or infection of patients in intensive care units (icus). surveillance cultures were obtained during a 4-month period from 162 faucet aerators located in seven different icus. the prevalence of colonization or infection of icu patients with nfgnb was determined by prospective surveillance durin ...200919587299
correlation between antibiotic consumption and resistance of gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009.this study investigated the correlation between antibiotic consumption and antimicrobial resistance in gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009.201121436153
microbial isolation and emergence of antimicrobial resistance associated with tigecycline usage.background: with the increasing experience of tigecycline usage, its ecological impact on microorganisms raises concerns but remains unknown. we aimed to analyze the difference in microorganisms isolated before, during, and after tigecycline usage and their susceptibility to antimicrobial agents. methods: between july 2008 and august 2009, 66 patients who received tigecycline monotherapy for more than 2 days at a taiwan medical center were enrolled. antimicrobial susceptibility testing was perfo ...201121524975
infections occurring during extracorporeal membrane oxygenation use in adult patients.the application of extracorporeal membrane oxygenation in adults has been increasing, but infections occurring during extracorporeal membrane oxygenation use are rarely described.201020708754
epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia.all bacterial isolates from 7058 patients admitted to haemato-oncology wards at national taiwan university hospital between 2002 and 2006 were characterized. in total 1307 non-duplicate bloodstream isolates were made from all patients with haematological malignancy; 853 (65%) of these were from neutropenic patients. gram-negative bacteria predominated (60%) in neutropenic isolates with escherichia coli (12%), klebsiella pneumoniae (10%), acinetobacter calcoaceticus-baumannii complex (6%), and st ...201019941686
multidrug resistance in clinical isolates of stenotrophomonas maltophilia: roles of integrons, efflux pumps, phosphoglucomutase (spgm), and melanin and biofilm formation.integrons, efflux pumps, phosphoglucomutase (spgm), and melanin and biofilm formation were investigated in 40 multidrug-resistant (mdr) and 30 non-mdr stenotrophomonas maltophilia isolates recovered from patients treated at national taiwan university hospital (taipei, taiwan). class 1 integrons were clearly associated with multidrug resistance. sequencing data revealed that aminoglycoside-modifying genes occurred most frequently in the integron and disclosed a new bla(imp-8)/aac6-ii/aada5 gene c ...201019926255
extensively drug-resistant stenotrophomonas maltophilia in a tertiary care hospital in taiwan: microbiologic characteristics, clinical features, and outcomes.a retrospective study was performed in a university-affiliated referral center from year 1999 to year 2004 to understand the trend of resistance in stenotrophomonas maltophilia isolates associated with nosocomial infections and describe the emergence of an extensively drug-resistant s. maltophilia (xdrsm). a 49% increase in all types of nosocomial infections and an 85% increase in nosocomial bloodstream infections caused by s. maltophilia were noted over the 5-year period. trends of resistance t ...200817950557
removal of cadmium ions during stationary growth phase by an extremely cadmium-resistant strain of stenotrophomonas sp.stenotrophomonas sp. cd02 was isolated from a site that previously had been contaminated with high concentrations of the heavy metals cadmium (3 mg kg(-1)) and chromium (115 mg kg(-1)). this strain was able to grow on complex (luria bertani) medium containing high concentrations of cadmium ion (up to 4 mm). additionally, it could remove up to 80% of the dissolved ions but only after reaching stationary growth phase. strain cd02 also tolerated high concentrations of other heavy metals such as chr ...200717447550
stenotrophomonas maltophilia bacteremia in pediatric patients-- a 10-year analysis.stenotrophomonas maltophilia bacteremia is an important cause of mortality among immunocompromised children. however, there has been little information concerning s. maltophilia bacteremia in the pediatric population.200616604247
stenotrophomonas maltophilia bacteremia in adults: four years' experience in a medical center in northern taiwan.stenotrophomonas maltophilia has become an important nosocomial pathogen in immunocompromised patients in taiwan. patients with underlying diseases such as diabetes, uremia, and solid malignancy are extremely vulnerable to this organism. s. maltophilia bacteremia has a mortality rate of up to 62% if appropriate antibiotics are not instituted early. knowledge of the risk factors for infection as well as local susceptibility patterns is helpful in determining which patients should receive empirica ...200415599468
implantable venous port-related infections in cancer patients.to evaluate the characteristics of implantable venous port-related infections in patients with malignancies.200414727170
risk factors for hospital acquisition of trimethoprim-sulfamethoxazole resistant stenotrophomonas maltophilia in adults: a matched case-control study.the emergence of trimethoprim-sulfamethoxazole resistant stenotrophomonas maltophilia (tsrsm) represents a serious threat to patients. the aim of current study was to identify risk factors associated with hospital-acquired tsrsm occurrence in adult inpatients.201728688829
stenotrophomonas maltophilia bloodstream infection: comparison between community-onset and hospital-acquired infections.stenotrophomonas maltophilia has been recognized as an important nosocomial pathogen, but few reports have discussed s. maltophilia infection in the community settings. this study aimed to reveal characteristics of patients with community-onset s. maltophilia bloodstream infection (smbsi), to specify the subgroup of healthcare-associated (hca) infection in the community-onset group and to compare them with hospital-acquired (ha) smbsi patients.201423040236
clinical characteristics and outcomes of patients with pleural infections due to stenotrophomonas maltophilia at a medical center in taiwan, 2004-2012.stenotrophomonas maltophilia can cause various clinical diseases; however, pleural infections due to s. maltophilia are rare. we evaluated the clinical characteristics and outcomes of patients with pleural infections (complicated parapneumonic effusion or empyema) due to s. maltophilia who were treated at a medical center in taiwan from 2004 to 2012. during the study period, 40 patients were treated for pleural infections due to s. maltophilia. the incidence of s. maltophilia pleural infections ...201424458500
a multicenter surveillance of antimicrobial resistance on stenotrophomonas maltophilia in taiwan.background: stenotrophomonas maltophilia has emerged as an important opportunistic pathogen in debilitated hosts. clinical management of s. maltophilia is challenging due to its intrinsic resistance to a variety of antibiotics. this study investigated the trend and prevalence of antimicrobial resistance in s. maltophilia from a nationwide surveillance study in taiwan. methods: s. maltophilia isolates were collected biennially between 1998 and 2008 as part of the taiwan surveillance of antimicrob ...201122154599
trends in the susceptibility of clinically important resistant bacteria to tigecycline: results from the tigecycline in-vitro surveillance in taiwan (tist), 2006-2010.the tigecycline in-vitro surveillance in taiwan (tist), a nationwide, prospective surveillance during 2006 to 2010, collected a total of 7,793 clinical isolates, including methicillin-resistant staphylococcus aureus (mrsa) (n=1,834), penicillin-resistant streptococcus pneumoniae (prsp) (n=423), vancomycin-resistant enterococci (vre) (n=219), extended-spectrum β-lactamase (esbl)-producing escherichia coli (n=1,141), esbl-producing klebsiella pneumoniae (n=1,330), acinetobacter baumannii (n=1,645) ...201122203598
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