| kaposi's sarcoma in childhood: an analysis of 100 cases from uganda and relationship to hiv infection. | we report 100 cases of kaposi's sarcoma (ks) in children under 15 years of age treated at the uganda cancer institute in the 6-year period 1989-1994. the incidence of childhood ks has risen more than 40-fold in the era of aids, and 78% of 63 cases tested were seropositive for hiv-1. there were 63 boys and 37 girls. the median age was 4 years and the median age of onset was 33 months. tumour distribution was lymphadenopathic and muco-cutaneous, with 2 major patterns: pattern i, oro-facial dominan ... | 1996 | 8567117 |
| human immunodeficiency virus and aids in uganda. | hiv-1 infection, initially described as "slim disease", was first recognized in uganda in 1982, and is now a predominant health problem. approximately 1.5 million ugandans are now infected, largely through heterosexual transmission. in many areas half of adult deaths are now caused by hiv. seroprevalence rates in urban antenatal clinics have been dropping in the last several years, as have rates in young adults in two rural community cohorts where the epidemic is long established. tuberculosis c ... | 1996 | 8625856 |
| risk factors for kaposi's sarcoma in hiv-positive subjects in uganda. | kaposi's sarcoma (ks) is associated epidemiologically with hiv infection and with human herpesvirus 8 (hhv-8 or kshv). both ks and hiv infection are common in uganda. we conducted a case-control study of 458 hiv-seropositive. ugandan adults with ks and 568 hiv-seropositive subjects without ks to examine risk factors for hiv-associated ks. | 1997 | 9365767 |
| prevalence of kaposi sarcoma-associated herpesvirus compared with selected sexually transmitted diseases in adolescents and young adults in rural rakai district, uganda. | kaposi sarcoma-associated herpesvirus (kshv) is transmitted by routes such as homosexual intercourse and is associated with hiv infection in industrialized countries. however, there is little information about its transmission in developing countries where kaposi sarcoma is an endemic disease. | 2001 | 11234789 |
| a case-control study of human immunodeficiency virus infection and cancer in adults and children residing in kampala, uganda. | uganda offers a unique setting in which to study the effect of human immunodeficiency virus-1 (hiv-1) on cancer. hiv-1 is prevalent there, and cancers which are known to be hiv-associated, such as kaposi's sarcoma and burkitt's lymphoma, are endemic. adults residing in kampala, uganda, presenting with cancer in city hospitals were interviewed and had an hiv test. of the 302 adults recruited, 190 had cancers with a potentially infectious aetiology (cases). the remaining 112 adults with tumours no ... | 2001 | 11340563 |
| the epidemiology of conjunctival squamous cell carcinoma in uganda. | as part of a larger investigation of cancer in uganda, we conducted a case-control study of conjunctival squamous cell carcinoma in adults presenting at hospitals in kampala. participants were interviewed about social and lifestyle factors and had blood tested for antibodies to hiv, kshv and hpv-16, -18 and -45. the odds of each factor among 60 people with conjunctival cancer was compared to that among 1214 controls with other cancer sites or types, using odds ratios, estimated with unconditiona ... | 2002 | 12177799 |
| the sero-epidemiology of kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) in adults with cancer in uganda. | the association between the prevalence of antibodies against kaposi's sarcoma-associated herpesvirus (kshv or human herpesvirus 8 [hhv-8]) and sociodemographic, sexual, reproductive and lifestyle factors was investigated in a study of adults presenting with cancer at hospitals in kampala, uganda. patients were interviewed and tested for antibodies against kshv (using an indirect immunofluorescent assay). data are presented for 607 patients who were not infected with the human immunodeficiency vi ... | 2003 | 12455037 |
| risk factors for kaposi's sarcoma: a case-control study of hiv-seronegative people in uganda. | as part of a larger investigation of cancer in uganda, we conducted a case-control study of kaposi's sarcoma in human immunodeficiency virus-1 (hiv)-seronegative adults presenting at hospitals in kampala. cases comprised 117 hiv-seronegative patients with kaposi's sarcoma and controls comprised 1,282 hiv-seronegative patients with a provisional diagnosis of cancer other than kaposi's sarcoma. study participants were interviewed about social and lifestyle factors, tested for hiv and, if there was ... | 2003 | 12455038 |
| transmission of human herpesvirus 8 by blood transfusion. | whether human herpesvirus 8 (hhv-8) is transmissible by blood transfusion remains undetermined. we evaluated the risk of hhv-8 transmission by blood transfusion in uganda, where hhv-8 is endemic. | 2006 | 17005950 |
| a case-control study of cancer of the uterine cervix in uganda. | as part of an epidemiological study of cancer in uganda, we investigated social, sexual and reproductive factors in relation to the risk of cancer of the uterine cervix. patients with all cancer types or with benign tumours were recruited from hospitals in kampala, uganda, interviewed about various demographic and lifestyle factors and tested for antibodies against the human immunodeficiency virus-1 (hiv). the case-control study reported here involves 702 hiv-seronegative women, 343 of whom were ... | 2007 | 18090129 |
| clinical presentation and outcome of epidemic kaposi sarcoma in ugandan children. | kaposi sarcoma (ks) is one of the most common pediatric cancers in sub-saharan africa. few data are available about the clinical presentation or response to treatment of children with epidemic (hiv-associated) ks. | 2010 | 20205254 |
| sex and geographic patterns of human herpesvirus 8 infection in a nationally representative population‐based sample in uganda. | human herpesvirus 8 (hhv8), the infectious cause of kaposi sarcoma, varies dramatically across africa, suggesting that cofactors correlated with large-area geographic or environmental characteristics may influence risk of infection. variation in hhv8 seropositivity across small-area regions within countries in africa is unknown. we investigated this issue in uganda, where kaposi sarcoma distribution is uneven and well described. | 2010 | 20863232 |