Publications

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group-b streptococci at a london hospital. 197772327
high level gentamicin resistance in enterococcal and streptococcal isolates from blood culture.the combination of an aminoglycoside with a cell wall active agent is often necessary for the satisfactory management of serious enterococcal and streptococcal infections. high level gentamicin resistance (mic > 1000 micrograms/ml) eradicates the synergy between these two classes of antibiotics and treatment of these infections becomes difficult. over a four year period we assessed the susceptibility of blood culture isolates of enterococci, streptococcus agalactiae (group b), and clinically sig ...19921453903
increased community-acquired septicaemic infection with group b streptococci in adults. 19911678104
the effect of udder infection on the bacterial flora of the bulk milk of ten dairy herds.the significance of udder infection as a factor increasing the bacterial count of herd bulk milk was measured monthly for one year in ten dairy herds in southern england. staphylococcus aureus or mastitis streptococci were detected in 86% of samples, usually in numbers between 1000 and 10 000 c.f.u./ml of milk. however, in 8 and 2% of samples respectively greater than 20 000 or 100 000 c.f.u. of mastitis pathogens/ml of milk were detected. this occurred most commonly in the herds with a high inc ...19846389466
nosocomial transmission of group b streptococci.the acquisition of group b streptococci by babies in a special-care baby unit and two postnatal wards was investigated over a six-month period using serology and phage typing. sixty-three culture-positive babies were identified in the postnatal wards, one-third of whom had been born to mothers who were not carrying the organism in the genital tract or anorectal area during labour. a non-maternal source was identified for 14 of these 21 infants: either colonised mothers and babies in the same war ...19816790015
neonatal meningitis in england and wales: a review of routine national data.the objective of this study was to describe trends in neonatal meningitis in england and wales during the years 1975-91. laboratory reports and, for the years 1983-91, data on statutory notifications and deaths from neonatal meningitis were reviewed. the mean annual total of laboratory reports of neonatal bacterial meningitis 1975-91 was 109 cases (range 69-133) with a slight upward trend apparent in the latter half of the study period. the mean annual number of reports of neonatal viral meningi ...19947979482
co-existent cross-infection with streptococcus pneumoniae and group b streptococci on an adult oncology unit.an outbreak of respiratory infection in an adult oncology unit is described where there was evidence of co-existent cross-infection with streptococcus pneumoniae serotype 14 and lancefield group b streptococcus type ia. the presumed route of transmission was droplet spread from patient to patient. no further cases arose after the ward had been closed to new admissions and all symptomatic patients were treated with erythromycin. we suggest that patients with pneumococcal pneumonia on units housin ...19938099926
non-steroidal anti-inflammatory drugs (nsaids). a predisposing factor for streptococcal bacteraemia? 19979331619
surveillance of neonatal group b streptococcal infection in sunderland.surveillance of neonatal group b streptococcus infection in sunderland identified 15 confirmed cases (with positive cultures from blood or csf) in three years from 1995 to 1997, equivalent to an incidence of 1.42 per 1000 live births, not much lower than the estimate of 1.8 used in the united states to justify the introduction of preventative policies. confirmed early-onset cases may represent only a fraction of the true number of cases, and a modified risk factor-based policy was introduced in ...199910462900
increased incidence of streptococcus agalactiae. 200212019541
increased incidence of streptococcus agalactiae. 200212019542
emerging trends in the epidemiology of invasive group b streptococcal disease in england and wales, 1991-2010.few cross-population studies examining the epidemiology of invasive group b streptococcal (gbs) disease have been undertaken. to identify longitudinal trends in the burden and characteristics of infections, national surveillance data on diagnoses in england and wales from 1991 to 2010 were analyzed.201323845950
group b streptococcal disease in infants: a case control study.to describe and quantify the maternal and neonatal factors associated with group b streptococcus (gbs) disease in infants <90 days of age.200919457879
characterization of group b streptococci recovered from infants with invasive disease in england and wales.group b streptococci (gbs) are a major cause of invasive disease in infants, with enhanced surveillance in england and wales showing an incidence of 0.74 cases per 1000 live births and a mortality rate of 8%. among 353 isolates obtained during enhanced surveillance, the predominant serotypes were iii (48%), ia (27%), and v (10%), and the remainder comprised ib, ii, iv, vi, and vii; 3% were not typable. isolates from patients with early-onset disease had serotypes iii (38%), ia (32%), and v (13%) ...200415127328
enhanced surveillance of neonatal group b streptococcal disease. 200010689775
invasive streptococcal infections in the era before the acquired immune deficiency syndrome: a 10 years' compilation of patients with streptococcal bacteraemia in north yorkshire.significant streptococcal (non-pneumococcal, non-enterococcal) bacteraemia was detected in 100 patients in two health districts of north yorkshire in the decade 1978-1988. patients with these infections accounted for 11% of the total 902 patients in the districts in whom bacteraemia was diagnosed during the period. infection was most often seen with beta-haemolytic streptococci (52 patients) comprising lancefield group a (streptococcus pyogenes) (20 patients), group b (13), group c (5), group g ...19892663996
the economic costs of group b streptococcus (gbs) disease: prospective cohort study of infants with gbs disease in england.the objective of this study was to estimate the economic costs over the first 2 years of life of group b streptococcus (gbs) disease occurring in infants less than 90 days of age. a cost analysis was conducted using a prospective cohort of children born between 2000 and 2003 in the greater london, oxford, portsmouth and bristol areas of england. unit costs were applied to estimates of the health and social resource use made by 138 infants diagnosed with gbs disease and 305 non-gbs controls match ...200919002511
risk factors for early onset neonatal group b streptococcal sepsis: case-control study.to quantify risk factors for and the prevalence of early onset group b streptococcal sepsis in neonates in a geographically defined population.200212169506
prospective surveillance of neonatal meningitis.neonatal meningitis is a serious problem with a high mortality and frequent neurological sequelae. the incidence of neonatal meningitis was calculated and the aetiology, clinical and laboratory features, and the treatment of cases recorded prospectively over a 7 year 8 month period was documented. it was further investigated whether secondary meningitis had occurred after lumbar puncture. the estimated incidence of bacterial, viral, and fungal meningitis was 0.25, 0.11, and 0.02 per 1000 live bi ...19938346945
changing patterns of communicable disease in england and wales. part i--newly recognised diseases. 19807000261
epidemiology of group b streptococci: one year's experience in an obstetric and special care baby unit.the epidemiology of group b streptococci (gbs) was studied in an obstetric unit and the related special care baby unit (scbu). in 1 year 53 (77%) of 69 babies who acquired gbs from their mothers were colonized within 24 h of birth, compared with only 9 (35%) of 38 who acquired gbs from non-maternal sources. while 38 (36%) of 107 gbs colonized babies in the obstetric unit derived the organism from a non-maternal source, the value for the scbu was only 2 (9%) of 23. in babies rectal and umbilical ...19836338902
group b streptococcal infection in a maternity unit.neonatal infection due to group b streptococci is described in a maternity unit. six babies were affected and two died. three of the babies were born at term, and weighed more than 2.5 kg. tachypnoea was the earliest clinical sign in each case, and we suggest that newborn infants with persistent tachypnoea and evidence of maternal or infant colonization with group b streptococci should receive antibiotics. alternative approaches to the diagnosis and management of infection with group b streptoco ...1978354686
early neonatal bacteraemia. comparison of group b streptococcal, other gram-positive and gram-negative infections.all cases of neonatal bacteraemia associated with clinical illness occurring at hammersmith hospital, over a 9-year period, 1967-1975 inclusive, have been reviewed. the infants studied were those born in the hospital's maternity unit and those admitted from other hospitals from a wide area round london who were ill or of low birthweight. positive blood cultures occurred in 91 infants, 47 of them in the first 48 hours of life. these 47 infants were analysed separately and divided into three group ...1977335983
evaluation of mastitis control programs. 1977326740
increased incidence of streptococcus agalactiae. 200211995691
early onset group b streptococcal neonatal infection in oxford 1985-96.of 74,920 babies live born in oxford between 1985 and 1996, 41 (0.5 per 1000 95% ci 0.4-0.7) developed definite, culture confirmed, early onset (< 48 hours) group b streptococcal infection and 32 (0.4 per 1000 95% ci 0.3-0.6) developed probable infection (sepsis plus colonisation). there was no significant variation in incidence with time. the mortality from definite infection was 19.5%, and from probable infection 6%. these data suggest that the incidence of group b streptococcal infection in o ...19989828744
neonatal group b streptococcal infection in south bedfordshire, 1993-1998.group b streptococcus (gbs) is now the leading cause of neonatal bacterial sepsis in the western world. the incidence of gbs infection in the united states has been determined, and guidelines produced and implemented for the prevention of neonatal infection. neither incidence nor guidelines are currently established in the united kingdom.200010794787
carriage of staphylococcus aureus and beta haemolytic streptococci in relation to race. 19744138503
distribution of serovariants of group b streptococci in isolates from england and norway.the distribution of capsular polysaccharide antigen (cho) types, surface-exposed c proteins alpha (c alpha) and beta (c beta) and an r-protein antigen was examined in 334 group b streptococci (gbs) isolates from three groups of patients hospitalised in england and wales or norway. the isolates were from 108 carriers, 67 cases of neonatal infection and 154 cases of adult infection. each group contained all cho types (ia, ib, ii, iii, iv, v and nt); type iii strains predominated except in the adul ...19957707331
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