ten years of occurrence of human leishmania viannia braziliensis (lvb) infections in farms around três braços, bahia-brazil. 19921308071
an outbreak of human leishmania (viannia) braziliensis infection.the occurrence of acute cutaneous leishmaniasis among inhabitants of 10 farms within 10 km of the hamlet of corte de pedra, bahia, brazil was studied prospectively from 1984-1989. a mean population of 1,056 inhabitants living in 146 houses were visited every 6 months and the number of skin ulcers recorded. a leishmanin skin test survey was done people with suggestive skin scars or active disease in 1984. the incidence of skin ulcers due to leishmania (viannia) braziliensis (lvb) reached 83/1,000 ...19911842411
leishmaniasis in bahia, brazil: evidence that leishmania amazonensis produces a wide spectrum of clinical hundred fourteen leishmania isolates from patients with different clinical forms of leishmaniasis in the state of bahia, brazil, were characterized by indirect radioimmune binding assay using specific monoclonal antibodies (serodeme analysis). seventy-five of these isolates were also analyzed by enzyme electrophoresis, based on 11 enzyme loci; parasite species were compared, according to their characteristic zymodemes, to those of who leishmania reference strains. all isolates could be class ...19912063957
lutzomyia intermedia as a suspected vector of leishmania viannia braziliensis in bahia state, brazil. 19902133592
mucosal leishmaniasis in brazil.the clinical diagnosis and laboratory identification of leishmania braziliensis braziliensis, a parasitic disease affecting the upper aerodigestive tract, is difficult. a retrospective computer-assisted analysis of patient records was done after examination of 58 patients with mucosal leishmaniasis in an endemic area of l. braziliensis braziliensis in bahia, brazil during january 1987. biopsies of clinically active and clinically inactive mucosal patients were examined for parasites using routin ...19892671555
[observations on kala azar in jacobina, bahia. vi. investigations on sylvatic and commensal mammals]. 19883068712
predominance of leishmania braziliensis braziliensis in the regions of três braços and corte de pedra, bahia, brazil. 19883232172
[natural infection of equus asinus by leishmania braziliensis braziliensis-bahia, brazil].in corte de pedra, valença, state of bahia, a donkey, equus asinus, was found naturally infected with leishmania braziliensis braziliensis. the parasite was isolated from a lesion located on a castration scar, and identified by means of monoclonal antibodies.19863587004
[experimental infection of lutzomyia whitmani in dogs infected with leishmania braziliensis braziliensis].lutzomyia (n.) whitmani was infected on leishmaniotic lesions of three out of nine dogs infected with leishmania braziliensis braziliensis. the infectivity rates in these sandflies were 8.3% (1/12), 7.1% (1/14) and 1.8% (3/160), respectively. in addition, 180 lu. whitmani fed on non-ulcerated regions of one of the infected dogs and none became infected. we emphasize the vector potentiality of lu. whitmani for l.b. braziliensis in the endemic region of três braços, bahia, brazil.19863796276
disseminated cutaneous leishmaniasis in a field clinic in bahia, brazil: a report of eight cases.eight bahian patients with cutaneous leishmaniasis who had 20 or more ulcerative lesions of short duration are described. of five identifications of isolated parasites, four were leishmania braziliensis braziliensis and one was l. mexicana amazonensis. all but one had positive montenegro tests initially, and all did after treatment. all had circulating anti-leishmanial antibodies and five responded well to glucantime therapy suggesting a functioning immune response. this is quite different to th ...19863806749
identification and distribution of new world leishmania species characterized by serodeme analysis using monoclonal antibodies.five hundred thirty stocks of leishmania isolated from human and domestic and wild reservoir hosts, representing a wide geographic distribution of endemic foci of american cutaneous (acl) and visceral leishmaniases (avl) were characterized and identified at species and/or subspecies levels based on their reactivity to a cross-panel of specific monoclonal antibodies using a radioimmune binding assay. this study confirms and extends our preliminary results on the high specificity of some of these ...19873826486
a focus of mucocutaneous leishmaniasis in três braços, bahia, brazil: characterization and identification of leishmania stocks isolated from man and dogs.the characterization and identification to species and subspecies of 20 stocks of leishmania isolated from the region of três braços, bahia, brazil, are described: 17 stocks were from patients and three from dogs. the following techniques were used (i) biological (growth in culture, hamster tissues and phlebotomine gut), (ii) biochemical (isoenzyme and kinetoplast dna analysis) and (iii) immunological (using monoclonal antibodies). all except two stocks belong to the l. braziliensis complex. one ...19853909556
leishmaniasis in brazil: xvii. enzymic characterization of a leishmania from the armadillo, dasypus novemcinctus (edentata), from pará state.a comparison of enzyme profiles, by starch-gel electrophoresis, has distinguished a leishmania of armadillos (dasypus novemcinctus), from pará state, north brazil, from leishmania braziliensis braziliensis, l. braziliensis guyanensis, l. mexicana amazonensis, l. donovani sensu lato (from bahia, brazil), and l. hertigi deanei. the parasite was separated from l. b. braziliensis and l. b. guyanensis by 8 of the 14 enzymes used (asat, alat, pgm, gpi, g6pd, pep, mpi and gd), although differences in t ...19827164148
personal experience with diagnostic and therapeutic aspects of human leishmania (viannia) braziliensis in três braços.diagnostic and therapeutic aspects of human infection with leishmania (viannia) braziliensis found in the littoral forest of the state of bahia are reviewed. there is pressing need for alternative cheap oral drug therapy.19947476237
clinical and immunopathological aspects of disseminated cutaneous leishmaniasis.the clinico-pathological and immunological findings in eight patients from bahia, brazil with disseminated cutaneous leishmaniasis are described. this condition differs from anergic diffuse cutaneous leishmaniasis (dcl) and from classical american cutaneous leishmaniasis (acl). the number of lesions in these patients ranged from 75 to 800 and were characterized by papules and an acneiform type of lesion with a few ulcers rather than nodules that are the main characteristic of dcl. on the other h ...19948023755
mucosal leishmaniasis due to leishmania (viannia) braziliensis l(v)b in três braços, bahia-brazil.brazilian mucosal leishmaniasis is briefly reviewed, emphasis being given to recent advances clinical management. patients continue to occupy much hospital bed space and in some cases are notoriously difficult to treat. indefinite follow up is recommended. many aspects of the aetiology remain mysterious although leishmania (viannia) braziliensis is the most common organism isolated. perspectives for a more effective treatment, oral and cheap, are still remote.19948073158
[an evolutionary study of mucosal leishmaniasis (a 7- to 17-year follow-up) due to leishmania (viannia) braziliensis in tres braços, bahia].seventy seven (68%) patients with mucosal leishmaniasis recorded during the period 1976-1986 in the region of três braços, bahia were traced and re-evaluated clinically, diagnostically and therapeutically. sixty-five patients were alive. the families of 12 dead patients were interviewed about probable cause of death. the 65 patients had a fresh clinical examination supplemented when necessary by a skilled ent examination. all had a titre of circulating immunofluorescent antibodies estimated at t ...19958668831
plants used in the treatment of leishmanial ulcers due to leishmania (viannia) braziliensis in an endemic area of bahia, brazil.this paper records the plants used in the treatment of cutaneous leishmaniasis due to leishmania (viannia) braziliensis (l(v)b) among the rural population of a cocoa-producing coastal area of bahia state, brazil. an enquiry conducted among a hundred patients identified 49 plants species used to treat skin ulceration caused by this leishmania species. the principal plants used are caju-branco (anacardium occidentale, anacardiaceae), used by 65% of the population, folha-fogo (clidemia hirta,melast ...19968701041
the sand fly fauna (diptera: psychodidae: phlebotominae) of a focus of cutaneous leishmaniasis in ilhéus, state of bahia, brazil.the municipality of ilhéus, state of bahia, has a focus of cutaneous leishmaniasis where entomological studies were carried out to determine the sand fly species and their habits. lutzomyia migonei, l. sallesi, l. tupynambai, l. schreiberi, l. intermedia, l. whitmani, l. yuilli yuilli, l. fischeri, l. pessoai, l. shannoni and l. misionensis were identified. lutzomyia whitmani was the predominant species. specimens were collected indoors, at peridomestic sites, in the cocoa plantations and in oth ...19968734952
morphometric and phenetic studies of five geographical populations of lutzomyia whitmani (diptera: psychodidae) in brazil.a morphometric survey examined adult specimens of lutzomyia whitmani (antunes & coutinho) captured at 5 municipalities in southeastern and northeastern brazil to compare the populations. the localities were ilhéus (bahia), martinho campos (minas gerais), corte de pedra (bahia), baturité (ceará), and amaraji (pernambuco): all are known foci of american cutaneous leishmaniasis. fifteen males and 15 females from each population were analyzed morphometrically for 42 and 37 characters, respectively. ...199910593089
[outbreak of american cutaneous leishmaniasis in canoa, santo amaro, bahia, brazil].an outbreak of american cutaneous leishmaniasis (acl) was detected in the village of canoa in 1993. a prospective observational study was outlined to determine the frequency rates and to clinically characterize the disease. a total of 555 people were followed up. there were 29 cases of acl, 11 cases of probably previous acl (scars) and 529 healthy individuals. of these 529 individuals, 65 had a positive montenegro reaction without any present or past evidence of leishmaniasis. the prevalence of ...199910881082
[socioeconomic factors and attitudes towards household prevention of american cutaneous leishmaniasis in an endemic area in southern bahia, brazil].a survey was conducted to identify socioeconomic conditions and attitudes towards household prevention of american cutaneous leishmaniasis in corte de pedra, located in the county of tancredo neves, an endemic region in southern bahia, brazil. a questionnaire was applied in july 1997, focusing on social and economic variables, habits, and attitudes towards prevention of arthropod bites. all families (100%) living in the study area were surveyed, comprising 168 households with 851 individuals. ap ...200011035509
comparison of cutaneous leishmaniasis due to leishmania (viannia) braziliensis and l. (v.) guyanensis in brazil: clinical findings and diagnostic approach.we compared the clinical findings and diagnostic methods for 66 patients with cutaneous leishmaniasis in the state of bahia, brazil, who were infected by leishmania (viannia) braziliensis (group a), with those for 68 patients in the state of amazonas, brazil, who were mainly infected by leishmania (viannia) guyanensis (group b). differences were observed with regard to number, size, and location of skin lesions and to the pattern of lymphatic involvement. patients in group b had smaller and more ...200111303265
frequency of infection of lutzomyia phlebotomines with leishmania braziliensis in a brazilian endemic area as assessed by pinpoint capture and polymerase chain reaction.leishmania infected of lutzomyia spp. are rare in endemic areas. we tested the hypothesis that there is clustering of infected vectors by combining pinpoint capture with sensitive l. braziliensis kdna minicircle specific pcr/dot blot in an endemic area in the state of bahia. thirty out of 335 samples (10 to 20 sand flies/sample; total of 4,027 female sand flies) were positive by pcr analysis and dot blot leading to a underestimated overall rate of 0.4% positive phlebotomines. however, 83.3% of t ...200212016439
[risk factors for cutaneous leishmaniasis transmission in children aged 0 to 5 years in an endemic area of leishmania (viannia) braziliensis].with the purpose of identifying risk factors for cutaneous leishmaniasis transmission in children from 0 to 5 years, a matched case-control study was carried out in corte de pedra, bahia, brazil, an endemic area of leishmania (viannia) braziliensis. children with a positive leishmanin skin test and one or more active lesions or scars consistent with cutaneous leishmaniasis were defined as cases. forty cases and 71 controls were selected and matched by age and place of residence. the presence of ...200515692649
[clinical findings of tegumentary leishmaniasis in children under five years of age in an endemic area of leishmania (viannia) braziliensis].a retrospective study was performed in a field clinic to characterize the clinical findings of tegumentary leishmaniasis in children from 0 to 5 years old. the clinical records of 4,464 patients were analyzed at the primary health center of corte de pedra, presidente tancredo neves, bahia, brazil, from may 1987 to december 1995. four hundred and ninety one (11.8%) children were identified among 4,275 new cases of tegumentary leishmaniasis registered at this unit. the gender ratio (m:f) for child ...200616501761
atypical manifestations of tegumentary leishmaniasis in a transmission area of leishmania braziliensis in the state of bahia, brazil.american tegumentary leishmaniasis (atl) can occur in different forms, classically categorised as cutaneous leishmaniasis, mucosal leishmaniasis, diffuse cutaneous leishmaniasis and disseminated leishmaniasis. we analysed the presence of atypical manifestations (vegetative, verrucous, crusted and lupoid) among a cohort of patients presenting to the health post of corte de pedra, bahia, brazil. among 1396 patients diagnosed with atl in 2005-2006, 35 patients (2.5%) presented with atypical manifes ...200919481233
resistance of leishmania (viannia) braziliensis to nitric oxide: correlation with antimony therapy and tnf-alpha production.nitric oxide (no) produced in macrophages plays a pivotal role as a leishmanicidal agent. a previous study has demonstrated that 20% of the l. (v.) braziliensis isolated from initial cutaneous lesions of patients from the endemic area of corte de pedra, bahia, brazil, were no resistant. additionally, 5 to 11% of the patients did not respond to three or more antimony treatments" (refractory patients). the aim of this study is to investigate if there is an association between the resistance of l. ...201020633260
miltefosine in the treatment of cutaneous leishmaniasis caused by leishmania braziliensis in brazil: a randomized and controlled trial.cutaneous leishmaniasis (cl) is treated with parenteral drugs for decades with decreasing rate cures. miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance.201021200420
age modifies the immunologic response and clinical presentation of american tegumentary leishmaniasis.leishmania (viannia) braziliensis is the main causal agent of american tegumentary leishmaniasis (atl) that may present as cutaneous, mucosal, or disseminated cutaneous leishmaniasis. the disease is highly prevalent in young males and there is a lack of studies of atl in the elderly. herein, we compared clinical manifestations, immunologic response, and response to antimony therapy between patients > 60 years of age (n = 58) and patients who were 21-30 years of age (n = 187). the study was perfo ...201525918209
leishmania (viannia) braziliensis in dogs in brazil: epidemiology, co-infection, and clinical aspects.leishmaniasis is an endemic disease present in 98 countries. in brazil, the northeast region accounts for approximately half of the cases in humans, and has experienced an increased number of positive cases in dogs. in this study, we investigated the epidemiology of canine leishmaniasis in the city of ilhéus, bahia, using serological and molecular techniques and evaluated the possible environmental risk factors and associated clinical signs. blood samples were collected from 560 dogs in urban an ...201526505353
host genetic factors in american cutaneous leishmaniasis: a critical appraisal of studies conducted in an endemic area of brazil.american cutaneous leishmaniasis (acl) is a vector-transmitted infectious disease with an estimated 1.5 million new cases per year. in brazil, acl represents a significant public health problem, with approximately 30,000 new reported cases annually, representing an incidence of 18.5 cases per 100,000 inhabitants. corte de pedra is in a region endemic for acl in the state of bahia (ba), northeastern brazil, with 500-1,300 patients treated annually. over the last decade, population and family-base ...201424863979
epidemiological and clinical changes in american tegumentary leishmaniasis in an area of leishmania (viannia) braziliensis transmission over a 20-year period.the health post of corte de pedra is located in a region endemic for american tegumentary leishmaniasis (atl) in the brazilian state of bahia, and it treats 500-1,300 patients annually. to describe temporal changes in the epidemiology of atl, we reviewed a random sample of 10% of patient charts (n = 1,209) from 1988 to 2008. there was a twofold increase in the number of cases over the 20-year period, with fluctuations in 10-year cycles. patients were most frequently male, between the ages of 10 ...201222403312
oral pentoxifylline associated with pentavalent antimony: a randomized trial for cutaneous leishmaniasis.abstractcutaneous leishmaniasis (cl) by leishmania braziliensis is associated with decreasing cure rates in brazil. standard treatment with pentavalent antimony (sb(v)) cures only 50-60% of the cases. the immunopathogenesis of cl ulcer is associated with high interferon-γ and tumor necrosis factor (tnf) production. pentoxifylline, a tnf inhibitor, has been successfully used in association with sb(v) in mucosal and cutaneous leishmaniasis. this randomized, double-blind, and placebo-controlled tri ...201728500815
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