| introduction and spread of multi-resistant shigella dysenteriae i in thailand. | outbreaks of shigella dysenteriae i occurred in northeastern thailand in the fall of 1986 and again in the spring and fall of 1987 for the first time in over 20 years. the epidemic strain of s. dysenteriae i was resistant to tetracycline, streptomycin, chloramphenicol, and trimethoprim-sulfamethoxazole, but susceptible to ampicillin. trimethoprim resistance was chromosomally encoded by type i dihydrofolate reductase. in ubon province, where 10,000 cases of dysentery were reported, there were 3-5 ... | 1989 | 2644859 |