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fourteen years of shigellosis in dhaka: an epidemiological analysis.we examined whether the proportion of shigellae patients among diarrhoeal cases, the distribution, species, case-fatality rates and hospital visits changed over time in dhaka. we isolated 19639 shigella strains from 822812 diarrhoea cases treated at the international centre for diarrhoeal disease research, bangladesh (icddr,b), between 1969 and 1982. the number of cases increased from 209 (2.5%) in 1969 to 4833 (7.7%) in 1976. extrapolating from a 4% vigorous systematic sample of icddr,b hospita ...19854086147
changing species distribution and antimicrobial susceptibility pattern of shigella over a 29-year period (1980-2008).we studied changes in species distribution and antimicrobial resistance patterns of shigella during 1980-2008, using the diarrhoeal diseases surveillance system of dhaka hospital of icddr,b. in hospitalized patients shigella prevalence decreased steadily from 8-12% in the 1980s to 3% in 2008. endemic s. flexneri was the most commonly isolated species (54%). epidemic s. dysenteriae type 1 had two peaks in 1984 and 1993, but was not found after 2000, except for one case in 2004. the therapeutic op ...201120478088
a novel serovar of shigella dysenteriae from patients with diarrhoea in bangladesh.every year, around 3 % of isolates from patients with diarrhoea at dhaka hospital, icddr,b, are identified as shigella-like organisms (slos) based on their activity in biochemical tests. these isolates do not react with any of the current shigella antisera including all existing and provisional serotypes. among these slos, a unique cluster of seven isolates with an identical plasmid profile was found and these isolates were further characterized by phenotypic and genotypic techniques. all were n ...200717446289
the emerging strains of shigella dysenteriae type 2 in bangladesh are clonal.a total of 113 strains of shigella dysenteriae type 2 isolated from patients attending the dhaka diarrhoea treatment centre of icddr,b: centre for health and population research during the period 1999-2004 were studied. serotype of the isolates was confirmed using commercially available antisera. except for arabinose fermentation, all the strains had similar biochemical reactions. more than 60% of the strains were sensitive to commonly used antibiotics; only 6% (n=7) of the strains were resistan ...200616684401
an unusual cluster of dysentery due to shigella dysenteriae type 4 in dhaka, bangladesh. 200515824434
temporal shifts in the dominance of serotypes of shigella dysenteriae from 1999 to 2002 in dhaka, bangladesh.a total of 358 shigella dysenteriae strains isolated from patients attending the dhaka treatment center of the international centre for diarrheal disease research, bangladesh, between the years 1999 and 2002 were included in this study. s. dysenteriae type 1, the dominant serotype in 1999 (76.4%), declined to 6.5% in 2002. on the other hand, s. dysenteriae types 2 to 12 were isolated with increasing frequencies of 19, 67, 73.5, and 87% in 1999, 2000, 2001, and 2002, respectively. of these, types ...200314605138
isolation of shigella dysenteriae type 1 and s. flexneri strains from surface waters in bangladesh: comparative molecular analysis of environmental shigella isolates versus clinical strains.bacillary dysentery caused by shigella species is a public health problem in developing countries including bangladesh. although, shigellae-contaminated food and drinks are often the source of the epidemic's spread, the possible presence of the pathogen and transmission of it through environmental waters have not been adequately examined. we analyzed surface waters collected in dhaka, bangladesh, for the presence of shigellae by a combination of pcr assays followed by concentration and culturing ...200212147489
central nervous system manifestations of childhood shigellosis: prevalence, risk factors, and outcome.alterations in consciousness, including seizures, delirium, and coma, are known to occur during shigella infection. previous reports have suggested that febrile convulsions and altered consciousness are more common during shigellosis than with other childhood infections. those reports, however, have been from locations where s dysenteriae type 1 was not common, thus making it difficult to assess the specific contribution that s dysenteriae type 1 infection, and shiga toxin, might make to the pat ...19999925864
shigellosis in children: a clinico-epidemiological comparison between shigella dysenteriae type i and shigella flexneri.we reviewed the clinical and epidemiological features of 390 children under 5 years of age infected with either shigella dysenteriae type i or shigella flexneri attending a diarrhoea treatment centre from 1993 to 1995 in dhaka, bangladesh. older age (24 months or more), underweight and wasting but not stunting were the host factors significantly more associated with shigella dysenteriae type i infection than in shigella flexneri-infected children. moreover, use of antibiotics at home, use of wat ...19989924557
changes in the trend of shigellosis in dhaka: family study on secondary infection, clinical manifestation and sensitivity pattern: 1980.the incidence of shigellosis and the death rate have increased and the resistance of shigellae to antibiotics has changed in dhaka during our experiences. in 1980, we investigated the secondary infection and case rates, infection to case ratio, duration of illness, excretion of shigellae and antibiotic sensitivity pattern in 100 families with cases of shigellosis, culturing rectal swabs obtained by home visits for a 10-day period. standard methods were used for culture and sensitivity tests. the ...19846380011
plasmid profile as a useful marker of a shigella dysenteriae type 1 strain causing an epidemic of shigellosis.plasmid profiles of 60 shigella dysenteriae type 1 isolates obtained during an epidemic period (april - october 1983) were compared with that of 74 other shigella species isolated during the same period of time and also with that of 20 s. dysenteriae type 1 isolates obtained before the epidemic period (1969 - 1982). all samples were collected during an epidemic of shigellosis from diarrhoeal patients being treated at the dhaka treatment centre of the international centre for diarrhoeal disease r ...19883077946
epidemiology of shigellosis in teknaf, a coastal area of bangladesh: a 10-year survey.the epidemiological data on shigellosis in teknaf, a coastal area of bangladesh, were reviewed for a 10-year period (1975-84). certain similarities and differences were observed in the epidemiology of the disease in teknaf when compared with urban dhaka and rural matlab. similarities included: round-the-year infection with two peaks, one in the monsoon period and the other in the winter period; high male to female attendance ratio at the treatment centre; the predominance of infection in the und ...19902200700
mortality due to shigellosis: community and hospital data.almost all fatal cases of shigellosis occur in developing countries, and data on mortality are generally compiled from three sources: investigations of epidemics caused by shigella dysenteriae type 1, surveillance of endemic diarrheal disease, and reports from hospitals. attack rates during epidemics of dysentery due to infection with s. dysenteriae type 1 have ranged from 1% to 33%, and case-fatality rates have ranged from 1% to 7%. in matlab, a rural district in bangladesh, most diarrhea-relat ...19912047645
intestinal obstruction during shigellosis: incidence, clinical features, risk factors, and outcome.to determine the incidence and outcome of intestinal obstruction during shigellosis, the authors assessed 1211 consecutive patients with shigellosis admitted during a 15-month period to a diarrhea treatment center in dhaka, bangladesh. obstruction was identified in 30 (2.5%) patients. ten (33.3%) of these patients died, compared with 97 (8.2%) of the 1181 patients without obstructions (p less than 0.001; rr = 4.1). in a case-control study, patients with obstructions were compared with 30 control ...19911860627
antimicrobial resistance of shigella isolates in bangladesh, 1983-1990: increasing frequency of strains multiply resistant to ampicillin, trimethoprim-sulfamethoxazole, and nalidixic acid.the susceptibility to ampicillin and trimethoprim-sulfamethoxazole (tmp-smz) was determined for 15,824 isolates of shigella obtained from patients attending a treatment center in dhaka, bangladesh, from 1983 through 1990 and for 520 isolates obtained during community surveys from 1988 through 1990. susceptibility to nalidixic acid was determined for isolates obtained after 1985. in 1983 13% of isolates were resistant to ampicillin, 23.5% to tmp-smz, and 0.8% to both drugs. by 1990 51.2% of isola ...19921600006
risk factors for mortality due to shigellosis: a case-control study among severely-malnourished children in bangladesh.to determine the risk factors for death of severely-malnourished bangladeshi children with shigellosis, a case-control study was conducted at the clinical research and service centre of icddr,b: centre for health and population research in dhaka, bangladesh. one hundred severely-malnourished children (weight-for-age <60% of median of the national center for health statistics), with a positive stool culture for shigella dysenteriae type 1 or s. flexneri, who died during hospitalization, were comp ...200516262023
contrasting epidemiology of shigellae dysenteriae and shigellae flexneri, dacca. 19807003832
death in shigellosis: incidence and risk factors in hospitalized patients.the total number of admissions and deaths of patients with shigellosis were ascertained at the dhaka treatment centre of the international centre for diarrhoeal disease research, bangladesh, 1974-1988, and the characteristics of 67 patients who died were compared with those of 134 discharged alive. of 9780 shigella-infected inpatients, 889 (9.1%) died; 32.3% of deaths occurred in children less than 1 year of age. fatality rates were highest (10.3%) in shigella sonnei-infected patients and lowest ...19902313128
reactive arthritis associated with shigella dysenteriae type 1 infection.shigella dysenteriae type 1 causes the most severe form of bacillary dysentery. the spectrum of illness ranges from mild watery diarrhoea to severe bloody diarrhoea. shigellosis is often associated with intestinal complications, including intestinal perforation, intestinal obstruction, toxic dilatation of the colon, and prolapse of the rectum; systemic complications include septicaemia, hyponatraemia, hypoglycaemia, seizure, encephalopathy, haemolytic-uraemic syndrome, and malnutrition. arthriti ...19979308297
multiple drug-resistant shigella dysenteriae type 1 in rajbari district, bangladesh.twenty-one shigellae isolates were obtained from bloody faecal specimens of diarrhoeal patients at rajbari district hospital from january 1994 to june 1995, and serogrouped. fourteen (67%) isolates belonged to the shigella dysenteriae serogroup and 7 (33%) to shigella flexneri serogroup. shigella dysenteriae strains were further serotyped; all were shigella dysenteriae 1. each strain was tested for resistance to 6 common antimicrobial agents. the two strains had different antibiotic susceptibili ...19979308296
epidemiology of shigella dysenteriae, type 1 infections, in dacca urban area.a prospective study of 47 families with an index case of shigella dysenteriae type 1 was conducted in the urban areas of dacca. the subsequent infection rates in contacts type 1 were 30.6% and 28.3% in the age groups 0--4 and 5--9. total secondary infection rate was 20.4% with rates in males higher than in females. among the contacts 12.5% developed diarrhoea caused by the same serotype, but 22.1% developed diarrhoea with undiagnosed causes. for one hospitalised case there were seven symptomatic ...1979388775
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