Publications

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a canine purgation study and risk factor analysis for echinococcosis in a high endemic region of the tibetan plateau.the tibetan plateau of western china has been shown to have a very high prevalence of human cystic echinococcosis (ce) caused by echinococcus granulosus and human alveolar echinococcosis (ae) caused by echinococcus multilocularis. the domestic dog is suspected to be the primary definitive host for the transmission of both e. granulosus and e. multilocularis to humans in this locality. a purgation study of 371 dogs in shiqu county, sichuan province during 2002-2003 resulted in an e. multiloculari ...200515619374
species identification of human echinococcosis using histopathology and genotyping in northwestern china.human cystic echinococcosis, caused by infection with the larval stage of echinococcus granulosus, and alveolar echinococcosis, caused by the larval form of e. multilocularis, are known to be important public health problems in western china. echinococcus shiquicus is a new species of echinococcus recently described in wildlife hosts from the eastern tibetan plateau and its infectivity and/or pathogenicity in humans remain unknown. in the current study, parasite tissues from various organs were ...200818396303
echinococcosis in tibetan populations, western sichuan province, china.we screened 3,199 people from shiqu county, sichuan province, china, for abdominal echinococcosis (hydatid disease) by portable ultrasound combined with specific serodiagnostic tests. both cystic echinococcosis (ce) (echinococcus granulosus infection) and alveolar echinococcosis (ae) (e. multilocularis) were co-endemic in this area at the highest village prevalence values recorded anywhere in the world: 12.9% were infected with one or the other form (6.8% ce and 6.2% ae). prevalences of both ce ...200516485472
molecular study of echinococcus in west-central china.west-central china is an important endemic focus of both alveolar and cystic echinococcosis where several species of intermediate host are commonly infected with echinococcus granulosus and e. multilocularis . isolates of e. granulosus were collected from humans and other animals from different geographical areas of qinghai, ningxia, gansu and sichuan, and genotyped using the mitochondrial dna marker atp synthase subunit 6 gene (atp6). the sheep strain (g1 genotype) of e. granulosus was shown to ...200516174420
development of an immunodiagnosis method using recombinant pscp for detection of paragonimus skrjabini infection in human.paragonimiasis skrjabini is a kind of zoonosis and prevalent in 16 provinces in china, such as chongqing, fujian, sichuan, and yunnan. however, sensitive and efficient diagnostic methods for the infection are limited. in order to provide a more convenient and simple method for serologic diagnosis, the recombinant p. skrjabini cysteine protease (pscp) was expressed, purified, and then used to develop an indirect enzyme-linked immunosorbent assay (elisa) for detecting anti-pscp antibodies in human ...201727796563
Post-treatment follow-up study of abdominal cystic echinococcosis in tibetan communities of northwest Sichuan Province, China.Human cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, with the liver as the most frequently affected organ, is known to be highly endemic in Tibetan communities of northwest Sichuan Province. Antiparasitic treatment with albendazole remains the primary choice for the great majority of patients in this resource-poor remote area, though surgery is the most common approach for CE therapy that has the potential to remove cysts and lead to complete cure. The current ...201122039558
modeling the transmission of echinococcus granulosus and echinococcus multilocularis in dogs for a high endemic region of the tibetan plateau.echinococcus granulosus and echinococcus multilocularis abundance and prevalence data, for domestic dogs of shiqu county, sichuan province, people's republic of china, were fitted to mathematical models to evaluate transmission parameters. abundance models, assuming the presence and absence of immunity, were fit for both e. granulosus and e. multilocularis using bayesian priors, maximum likelihood, and monte carlo sampling techniques. when the models were compared, using the likelihood ratio tes ...200515710437
study of infection of echinococcus granulosus in yak in spring and its potential role in transmission of cystic echinococcosis in rangtang county of sichuan, china. 201323425806
genetic variability of echinococcus granulosus from the tibetan plateau inferred by mitochondrial dna sequences.to analyse genetic variability and population structure, 84 isolates of echinococcus granulosus (cestoda: taeniidae) collected from various host species at different sites of the tibetan plateau in china were sequenced for the whole mitochondrial nad1 (894 bp) and atp6 (513 bp) genes. the vast majority were classified as g1 genotype (n=82), and two samples from human patients in sichuan province were identified as g3 genotype. based on the concatenated sequences of nad1+atp6, 28 different haplot ...201323523013
epidemiology and risk factor analysis for canine echinococcosis in a tibetan pastoral area of sichuan.to determine the prevalence and evaluate the risk factors of canine echinococcosis based on a field survey of dog infections with echinococcus granulosus and e. multilocularis in chalong, kalong, dade and chazha townships in a district of ganzi county, sichuan province, china.200824818363
echinococcus granulosus infection and options for control of cystic echinococcosis in tibetan communities of western sichuan province, china.human cystic echinococcosis (ce) is highly endemic in the tibetan regions of sichuan where most families keep guard dogs and where there are considerable numbers of ownerless/stray dogs. strong buddhist beliefs do not allow for elimination of stray dogs, and many strays are actually fed and adopted by households or monasteries. on account of the high altitude (3900-5000 m), pasturage is the major agricultural activity in this area. the harsh mountainous climate often leads to many grazing animal ...200919399162
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