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prevalence of anti-leishmania donovani antibody among brazilian blood donors and multiply transfused hemodialysis patients.the prevalence of anti-leishmania donovani antibodies was investigated in 1,500 brazilian blood donors and multiply transfused hemodialysis patients. sera were tested using the fucose-mannose ligand (fml) elisa, which was shown to have 100% sensitivity and 96% specificity for kala-azar. among 1,194 volunteer blood donors, seroreactivity was 9%, increasing to 25% in a periurban kala-azar focus. however, higher positivity (37%) was found in multiply transfused hemodialysis patients from natal, whe ...19979288810
the fml (fucose mannose ligand) of leishmania donovani. a new tool in diagnosis, prognosis, transfusional control and vaccination against human kala-azar.the fucose-mannose ligand (fml) of leishmania donovani is a complex glycoproteic fraction. its potential use as a tool for diagnosis of human visceral leishmaniasis was tested with human sera from natal, rio grande do norte, brazil. the fml-elisa test, showed 100% sensitivity and 96% specificity, identifying patients with overt kala-azar (p < 0.001, when compared to normal sera), and subjects with subclinical infection. more than 20% apparently healthy subjects with positive reaction to fml deve ...19968713607
leishmania donovani: titration of antibodies to the fucose-mannose ligand as an aid in diagnosis and prognosis of visceral leishmaniasis.the fucose-mannose ligand (fml) is a complex glycoprotein fraction present on promastigotes and amastigotes of leishmania donovani. it participates in parasite interaction with host macrophages in a species-specific pattern. we have tested its use in immunodiagnosis of visceral leishmaniasis (vl) in a recent outbreak in rio grande do norte, north-east brazil. enzyme-linked immunosorbent assay (elisa) of low concentrations of fml in 462 sera showed 100% sensitivity and 96% specificity. the fml-el ...19957570874
short report: occurrence of leishmania donovani dna in donated blood from seroreactive brazilian blood donors.human visceral leishmaniasis (kala-azar) transmitted by blood transfusion has been described in previous reports. seroprevalence of antibodies to leishmania donovani was shown to be related to prior blood transfusions in multiply transfused hemodialysis patients in natal, rio grande do norte, brazil. in this study, a possible correlation between seroreactivity and the presence of l. donovani dna was investigated in asymptomatic healthy blood donors. sera were tested using the fucose mannose liga ...200010761737
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