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[the ratios and kinds of clinical bacteria isolated in taiwan's large-size hospitals].the prevalence of clinical bacteria, as isolated from linko chang-gung memorial hospital (2,300 beds) in the period january 1985 to december 1986 and from taipei veterans general hospital (2,300 beds) during the period january 1986 to december 1986, was analyzed with the following findings: (i) the isolation ratio of anaerobic and aerobic or facultative bactria during the period of investigation were 7.8% (5,513/70,799) and 92.2% (65,286/70,799), respectively. (ii) of the total aerobic or facult ...19892791722
the prognostic factors of adult gram-negative bacillary meningitis.seventy-seven patients with gram-negative bacillary meningitis (gnbm), 57 males and 20 females, aged 17-86 years, were identified at kaohsiung chang gung memorial hospital, over an 11-year period. fifty-four infections were community-acquired, and 23 were nosocomial; 49 were spontaneous and 28 occurred after head surgery or neurosurgery. the organisms most frequently involved were klebsiella pneumoniae, pseudomonas aeruginosa, escherichia coli, and acinetobacter. rarer pathogens included citroba ...19989777518
characteristics of neonatal bacterial meningitis in a teaching hospital in taiwan from 1984-1997.during the period from 1984 to 1997, 85 bacterial meningitis neonates with positive cerebrospinal fluid cultures were treated. the ages of these patients ranged from 1 to 28 days. the male to female ratio was 1.7 to 1. the most common causative agent was group b beta-hemolytic streptococci (gbs, 31.8%), followed by escherichia coli (20%), proteus mirabilis (7.1%), enterobacter cloacae (5.9%), other streptococci excluding streptococcus pneumoniae (5.9%), chryseobacterium meningosepticum (5.9%), e ...200010917879
emerging fluoroquinolone-resistance for common clinically important gram-negative bacteria in taiwan.the in vitro antimicrobial activity of the three most commonly used fluoroquinolones (norfloxacin, ofloxacin and ciprofloxacin) was measured for 2235 isolates of seven common pathogenic gram-negative bacteria. collected from a major teaching hospital in taiwan during the years 1985-86, 1989-90, and 1996-97, the samples were evaluated using the agar dilution method. the overall susceptibility to fluoroquinolones has decreased rapidly after the wide use of these antimicrobial agents. isolates of e ...200212088622
the status of antimicrobial resistance in taiwan among gram-negative pathogens: the taiwan surveillance of antimicrobial resistance (tsar) program, 2000.in a nationwide surveillance of antimicrobial resistance (taiwan surveillance of antimicrobial resistance, tsar), isolates were collected from 21 medical centers and regional hospitals throughout taiwan over a three-month period in 2000 (tsar ii). this report summarizes susceptibility data of 7 common gram-negative bacilli (escherichia coli, klebsiella pneumoniae, serratia marcescens, proteus mirabilis, enterobacter cloacae, pseudomonas aeruginosa, and acinetobacter baumannii) in the tsar ii col ...200415023432
in vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in taiwan.this study evaluated the in vitro activities of tigecycline, ertapenem, isepamicin, and other comparators against 861 bacterial isolates recovered from patients treated in three major teaching hospitals in 2003. mics to antimicrobial agents were determined by the agar dilution method. high rates of oxacillin resistance (58%) in staphylococcus aureus (60 isolates), and vancomycin resistance (21%) and quinupristin-dalfopristin non-susceptibility (39%) in enterococcus faecium (34 isolates) were fou ...200516359192
dissemination of proteus mirabilis isolates harboring ctx-m-14 and ctx-m-3 beta-lactamases at 2 hospitals in taiwan.from february to june 2003, 111 clinical isolates of proteus mirabilis were mainly isolated from patients with respiratory or urinary tract infections hospitalized at 3 district hospitals (a, b, c) in central taiwan. among them, 34 (30.6%) strains, isolated within 2 hospitals (a and b), exhibited nonsusceptibility to cefotaxime with significant reduction of mic (> or = 3 log2 dilution) by the effect of clavulanic acid, which confirmed the phenotype of extended-spectrum beta-lactamases (esbls). t ...200616406185
extended-spectrum beta-lactamases in taiwan: epidemiology, detection, treatment and infection control.extended-spectrum beta-lactamases (esbls) efficiently hydrolyze extended-spectrum beta-lactams such as cefotaxime, ceftriaxone, ceftazidime, and aztreonam. esbls are most often plasmid-mediated. in taiwan, the prevalence of esbls in bacteria has risen, ranging from 8.5 to 29.8% in klebsiella pneumoniae and 1.5 to 16.7% in escherichia coli isolates. the most prevalent types of esbls are shv-5, shv-12, ctx-m-3, and ctx-m-14 in isolates of k. pneumoniae and e. coli, with differences between institu ...200616926972
prevalence of extended-spectrum beta-lactamases in proteus mirabilis in a taiwanese university hospital, 1999 to 2005: identification of a novel ctx-m enzyme (ctx-m-66).a total of 1574 nonduplicate proteus mirabilis isolates collected at a taiwanese hospital during 1999 to 2005 were analyzed for production of extended-spectrum beta-lactamases (esbls). forty-four esbl-producing isolates including 22 ctx-m-14, 18 ctx-m-3, 2 ctx-m-24, and 2 ctx-m-66 producers were detected, and the proportion of esbl producers increased from 0.7% in 1999 to approximately 6% after 2002. ctx-m-66 is a novel variant of ctx-m esbls that differs from ctx-m-3 by a ser to asn change at a ...200817913434
fournier's gangrene: ten-year experience in a medical center in northern taiwan.fournier's gangrene is a life-threatening infection. the mortality is still high despite the rapid advancement of modern intensive care and surgical technique. in this study, we present our institution's recent experience with a large series of patients with fournier's gangrene.200718087630
antimicrobial resistance of bacterial isolates from respiratory care wards in taiwan: a horizontal surveillance study.a horizontal surveillance study was conducted to identify common bacteria and mycobacteria from 611 respiratory aspirates and 165 urinary samples from 611 patients hospitalised at 17 respiratory care wards (rcws) in taiwan. some major resistance phenotypes, including methicillin-resistant staphylococcus aureus (mrsa), extended-spectrum beta-lactamase (esbl)-producing escherichia coli, klebsiella pneumoniae and proteus mirabilis, and multidrug-resistant pseudomonas aeruginosa (mdr-pa) and acineto ...200818358701
nationwide surveillance of antimicrobial resistance among enterobacteriaceae in intensive care units in taiwan.to determine the antimicrobial resistance profiles among clinical isolates of enterobacteriaceae in taiwanese intensive care units (icus), a national surveillance of antibiotic resistance among important enterobacteriaceae was conducted from september 2005 through november 2005 at the icus of ten major teaching hospitals in taiwan. a total of 574 enterobacteriaceae isolates recovered from various clinical samples of our icu patients were submitted for in vitro test. minimum inhibitory concentrat ...200918716805
nationwide surveillance in taiwan of the in-vitro activity of tigecycline against clinical isolates of extended-spectrum beta-lactamase-producing enterobacteriaceae.tigecycline in-vitro surveillance in taiwan (tist), initiated in 2006, is a nationwide surveillance programme designed to monitor longitudinally the in-vitro activity of tigecycline against commonly encountered resistant bacteria. this study compared the in-vitro activity of tigecycline against clinical isolates of resistant gram-negative bacteria determined by the broth microdilution and etest methods. a total of 622 isolates were collected from patients treated at 20 teaching hospitals. tigecy ...200819013351
changing trend in antimicrobial resistance of pediatric uropathogens in taiwan.there is growing concern regarding antimicrobial resistance worldwide, particularly of escherichia coli, and the first choice of an antimicrobial agent for empiric treatment of pediatric urinary tract infection (uti) is not well established.200819067894
clinical aspects and genetic analysis of taiwanese patients with the phenotype of hyper-immunoglobulin e recurrent infection syndromes (hies).hyper-immunoglobulin e recurrent infection syndromes (hies) has characteristic features and identified mutations. this study investigated clinical features and causal candidate mutations in taiwanese patients with the hies phenotype on referral base over 23 million inhabitants.201021120687
rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: results from the surveillance of multicenter antimicrobial resistance in taiwan (smart).data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (mics) of important carbapenem agents among important pathogens collected in intensive care units (icus) in taiwan are lacking.201625661253
carbapenem susceptibilities and non-susceptibility concordance to different carbapenems amongst clinically important gram-negative bacteria isolated from intensive care units in taiwan: results from the surveillance of multicentre antimicrobial resistance in taiwan (smart) in 2009.to investigate the in vitro susceptibilities to various carbapenems amongst clinical gram-negative bacteria isolated from patients in intensive care units of ten major teaching hospitals in taiwan in 2009, a survey was conducted to determine the minimum inhibitory concentrations (mics) of ertapenem, imipenem, meropenem and doripenem against isolates of enterobacteriaceae (n = 594), pseudomonas aeruginosa (n = 185), acinetobacter baumannii (n = 192) and burkholderia cepacia (n = 23) using the aga ...201323507415
risk factors of community-onset urinary tract infections caused by plasmid-mediated ampc β-lactamase-producing enterobacteriaceae.the ampc β-lactamase (ampc)-producing enterobacteriaceae emerged worldwide. this study was conducted to determine the risk factors of community-onset urinary tract infections (utis) caused by plasmid-mediated ampc-producing enterobacteriaceae.201524239065
relationship between the distribution of cefepime minimum inhibitory concentrations and detection of extended-spectrum β-lactamase production among clinically important enterobacteriaceae isolates obtained from patients in intensive care units in taiwan: results from the surveillance of multicenter antimicrobial resistance in taiwan (smart) in 2007.the data on susceptibility of important cephalosporins against four enterobacteriaceae members producing potential extended-spectrum β-lactamase (esbl) collected from taiwanese intensive care units are lacking.201523973410
molecular epidemiology of ctx-m-type extended-spectrum β-lactamase-producing proteus mirabilis isolates in taiwan. 201525446905
proteus mirabilis urinary tract infection and bacteremia: risk factors, clinical presentation, and outcomes.proteus mirabilis is a common pathogen responsible for complicated urinary tract infections (utis) that sometimes causes bacteremia. most cases of p. mirabilis bacteremia originate from a uti; however, the risk factors for bacteremia and mortality rates from p. mirabilis uti have not been determined.201222572004
antimicrobial susceptibilities of proteus mirabilis: a longitudinal nationwide study from the taiwan surveillance of antimicrobial resistance (tsar) program.longitudinal nationwide data on antimicrobial susceptibility in proteus mirabilis from different sources are rare. the effects of the revised clinical and laboratory standards institute (clsi) β-lactam breakpoints on susceptibility rates and on detecting extended-spectrum β-lactamase (esbl) and ampc β-lactamase-producers in this species are also seldom evaluated. the present study analyzed data from the taiwan surveillance of antimicrobial resistance program to address these issues.201425192738
risk factors and clinical impact of levofloxacin or cefazolin nonsusceptibility or esbl production among uropathogens in adults with community-onset urinary tract infections.gram-negative bacilli causing community-onset urinary tract infections (coutis) are getting increasingly resistant to antimicrobial agents. clinical significance and risk factors of the acquisition of antimicrobial-nonsusceptible pathogens are still under investigation.201423063776
antimicrobial susceptibility of clinical enterobacteriaceae isolates at the emergency department in a regional hospital: a threat of extended spectrum beta-lactamase-producers among nursing home residents.the prevalence of extended spectrum beta-lactamase (esbl)-producing enterobacteriaceae in nursing home residents has rarely been reported in taiwan.201626692184
antimicrobial susceptibility profiles of gram-negative bacilli isolated from patients with hepatobiliary infections in taiwan: results from the study for monitoring antimicrobial resistance trends (smart), 2006-2010.we investigated the trends in antimicrobial resistance among species of gram-negative bacilli isolated from patients with hepatobiliary tract infections in taiwan during the period 2006-2010 as part of the study for monitoring antimicrobial resistance trends (smart). during the study period, 1032 isolates of gram-negative bacilli that had been collected from patients with hepatobiliary infections were tested for susceptibility to 12 antimicrobial agents in accordance with the clinical and labora ...201222749054
high prevalence and antimicrobial resistance of urinary tract infection isolates in febrile young children without localizing signs in taiwan.antimicrobial susceptibility and prevalence of pediatric urinary tract infection (uti) is very useful for pediatricians in selecting effective antibiotics in time to improve outcomes in patients. this study aimed to determine the prevalence rate, bacterial distribution, and antimicrobial susceptibility of uti in febrile young children at a teaching hospital in northern taiwan.201626299351
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