is hospital-acquired intravascular catheter-related sepsis associated with outbreak strains of coagulase-negative staphylococci?macrorestriction fragment profile analysis by pulsed field gel electrophoresis was used to type strains of coagulase-negative staphylococci (cns) isolated from 30 patients with catheter-related sepsis at the university hospital birmingham nhs trust, uk. twenty-three infections were hospital-acquired. a total of 56 cns were isolated from the patients and identified by api as staphylococcus epidermidis (54), staphylococcus lugdunensis (1) and staphylococcus hominis (1). the micro-organisms were fu ...200011049706
mechanism of late prosthetic vascular graft infection.this study was a retrospective analysis of 41 patients with late prosthetic graft infections (> 30 days after operation) from six hospitals in the south-west of england. the 41 patients had a median age of 66 years and generally accepted risk factors for infection were documented in 19 patients preoperatively. thirteen patients had postoperative wound complications and three had early reoperation at the site of subsequent infection. the median time between index operation and symptoms of infecti ...19979464605
low-dose vancomycin prophylaxis reduces coagulase-negative staphylococcal bacteraemia in very low birthweight infants.very low birthweight (vlbw) infants undergoing neonatal intensive care are at risk of infection with coagulase-negative staphylococci (cons). this study investigates the efficacy of twice daily, 1 h infusions of vancomycin (5 mg kg) in reducing cons infection in vlbw infants receiving parenteral nutrition. of 72 infants in the study, 37 were randomized to vancomycin and 35 to the control group. clinical variables and mortality were similar in both groups. in the vancomycin group, 11 infants had ...19979457607
treatment of endocarditis with teicoplanin: a retrospective analysis of 104 cases.infective endocarditis is an uncommon disease but retains a high mortality. glycopeptides are used for patients with resistant pathogens, those allergic to penicillins or for those outside the hospital. the once daily administration of teicoplanin and its low toxicity suggest that it would be suitable for use in the long courses required for endocarditis. however, the dosage and combinations to be used require further study. a retrospective review has been made of 104 episodes of endocarditis tr ...19968889725
changing blood culture isolates in a referral neonatal intensive care analysis was made of all cases of bacteraemia that had occurred in the referral neonatal intensive care unit at hammersmith hospital during the years 1976--79. one hundred and thirteen infants had positive blood cultures; 27 were born in the hospital, and 86 admitted from elsewhere. this gave a rate of 5.7/1000 live hospital births, and 165/1000 outborn admissions to the unit. the latter infants were predominantly of very low birthweight or were ill. thirty-three of the isolates were cultured ...19817305416
increase in native valve endocarditis caused by coagulase negative staphylococci: an anglo-french clinical and microbiological study.native valve endocarditis caused by coagulase negative staphylococci has become more common. a study of 35 cases showed that the infections were usually acquired in the community and occurred in men (mean age 51 years). a pre-existing cardiac abnormality (mitral leaflet prolapse in a third of patients) was detected in 26 (74%). the source of the organisms in the community acquired infections was assumed to be the skin, though lesions were seldom demonstrated; most hospital acquired infections re ...19902271345
infection in total joint replacements. why we screen mrsa when mrse is the problem?a retrospective review of mrsa screening showed that of a total of 8911 patients screened pre-operatively between may 1996 and february 2001, 83 (0.9%) had mrsa isolated from one source or another. during the same period, 115 (13.6%) of 844 positive tissue samples taken during surgery grew staphylococcus aureus. of these only 1 (0.01%) was reported to be methicillin-resistant (mrsa). however, a total of 366 (43.4%) isolates from tissue samples were reported as coagulase-negative staphylococci (c ...200415046444
bacteraemia in the adult intensive care unit of a teaching hospital in nottingham, uk, 1985-1996.bacteraemia is an important cause of morbidity and mortality in the intensive care unit. in this study the distribution of organisms causing bacteraemic episodes in patients in the adult intensive care unit of a large teaching hospital was determined. particular emphasis was placed on the type of organisms isolated from community- and hospital-acquired bacteraemia, the suspected source of infection, the possible risk factors associated with bacteraemia, and outcome. the incidence of bacteraemia ...19989758274
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