| [rocky mountain spotted fever]. | after returning from a holiday in the usa a 24-year-old man fell ill with diarrhoea, high fever and marked rash including the palms of the hands and soles of the feet. when a history of a tick bite in the usa was elicited, a rickettsial infection was suspected. treatment with doxycycline, 100 mg twice daily, was instituted finally and the fever slowly resolved. the patient became completely well again within four weeks. serological tests confirmed the diagnosis of rocky mountain spotted fever. | 1990 | 2104798 |
| antibodies to spotted fever-group rickettsiae in dogs in north carolina. | a seroepidemiologic survey was conducted to determine the prevalence of antibodies reactive with 4 spotted fever-group (sfg) rickettsiae in sera of dogs from various geographic regions in north carolina. serum specimens were obtained from 600 dogs, and antibody titers were determined, using microimmunofluorescence. data analysis (setting as the criterion for a positive result, a rickettsia rickettsii titer greater than or equal to 1:64) overestimated the actual prevalence of canine exposure to t ... | 1987 | 3118744 |
| the prevalence of antibodies to rickettsia rickettsii in an area endemic for rocky mountain spotted fever. | a study of rickettsia rickettsii was conducted in rowan, cabarrus, and granville counties, north carolina in an attempt to define the prevalence of endemic infection in this area. serum samples were obtained from 1,976 healthy persons and tested by indirect hemagglutination for detectable antibodies to r. rickettsii. of this group, 568 (28.7%) had detectable antibody (greater than or equal to 1:8), 80 (4%) had titers greater than or equal to 1:64, and 1,408 (70%) had no detectable antibody (less ... | 1985 | 3921622 |
| rocky mountain spotted fever vaccine: a regional need. | because the killed rickettsia vaccines have failed to provide protection against rocky mountain spotted fever, we approached the problem of protective immunity to rickettsia rickettsii with a closely related, live, less pathogenic spotted fever rickettsia. guinea pigs vaccinated with r conorii produced antibodies to spotted fever group rickettsiae and did not have fever or other signs of illness after challenge with r rickettsii. a vaccine against rocky mountain spotted fever would be useful in ... | 1984 | 6424239 |
| epidemic typhus in the united states associated with flying squirrels. | between july 1977 and january 1980, seven cases of sporadic, nonepidemic "epidemic" typhus (rickettsia prowazekii) were discovered in virginia, west virginia, and north carolina. the reservoir seemed to be the southern flying squirrel (glaucomys volans), an animal indigenous to the eastern united states; however, the vector or mode of acquisition was not evident. diagnosis was established principally through complement fixation, indirect immunofluorescence, and toxin neutralization tests. patien ... | 1981 | 6785459 |
| rocky mountain spotted fever. serological evidence of previous subclinical infection in children. | serological tests for rocky mountain spotted fever were performed on single serum specimens from sixth graders from forsyth county, north carolina, an area highly endemic for this disease. five of 508 *.098%) sera were positive (titer greater than or equal to 1:64) using the indirect fluorescent antibody method. elevated proteus agglutination antibody titers (greater than 1:160) to ox-19, but not ot ox-2, were common (19.6%) in these children. no correlation of those with positive ox-19 titers c ... | 1982 | 6798859 |
| rocky mountain spotted fever in areas of high and low prevalence: survey for canine antibodies to spotted fever rickettsiae. | antibodies to rickettsia rickettsii were detected by indirect immunofluorescence in sera from 149 of 467 dogs (32%) examined from 4 military installations located in kentucky, north carolina, pennsylvania, and virginia. the prevalence at individual installations ranged from 4.3% at fort knox, ky, to 63.4% at fort bragg, nc. most of the seropositive dogs were in the working and sporting groups of dogs. the difference in antibody prevalence between sexes was not significant. serologic responses we ... | 1982 | 6808878 |
| erythema migrans-like rash illness at a camp in north carolina: a new tick-borne disease? | borrelia burgdorferi, the causative agent of lyme disease, has never been isolated from a patient thought to have acquired lyme disease in any southeastern state. | 1997 | 9531233 |
| canine rocky mountain spotted fever: a retrospective study of 30 cases. | rocky mountain spotted fever (rmsf) was diagnosed in 30 dogs examined at north carolina state university, veterinary teaching hospital between 1984 and 1997. historical, physical examination, and laboratory abnormalities were reviewed. diagnostic criteria included a four-fold rise in antibody titer to rickettsia rickettsii (r. rickettsii) (n=15) or a single r. rickettsii antibody titer of 1:1,024 or greater (n=15; when this initial titer was determined one week or more after the onset of clinica ... | 2001 | 11204476 |
| antinuclear antibodies can be detected in dog sera reactive to bartonella vinsonii subsp. berkhoffii, ehrlichia canis, or leishmania infantum antigens. | the presence of antinuclear antibodies (anas) is used to support a clinical diagnosis of systemic lupus erythematosus (sle) in dogs. however, clinicians must interpret the detection of anas with caution, particularly in light of increasing evidence that dogs with known bacterial and protozoal infections can have high ana titers. retrospectively, medical records were reviewed for all dogs that were concurrently tested for antinuclear antigens and bartonella vinsonii (berkhoffii), ehrlichia canis, ... | 2004 | 14765731 |
| bartonella henselae igg antibodies are prevalent in dogs from southeastern usa. | in contrast to the large body of literature regarding bartonella henselae in humans and cats, there is little information about b. henselae as an infectious agent in dogs. due to the paucity of information regarding the b. henselae serology in dogs, we performed a cross-sectional serosurvey using b. henselae antigen in order to compare the seroprevalence between sick and healthy dogs from the south-eastern usa. ninety-nine sera were collected from clinically healthy dogs. three hundred and one s ... | 2004 | 15369661 |
| molecular characterization of rickettsia rickettsii infecting dogs and people in north carolina. | rocky mountain spotted fever (rmst) is an important cause of morbidity and mortality in people and dogs in the united states. disease manifestations are strikingly similar in both species, and illness in dogs can precede illness in people. r. rickettsii has been identified as a select agent by the cdc as a category c priority pathogen by the national institute of allergic and infectious diseases because it is amenable to use as a bioterror agent. the clinical and temporal relationship of natural ... | 2006 | 17114748 |
| tick-borne diseases in north carolina: is "rickettsia amblyommii" a possible cause of rickettsiosis reported as rocky mountain spotted fever? | cases of rocky mountain spotted fever (rmsf) in north carolina have escalated markedly since 2000. in 2005, we identified a county in the piedmont region with high case numbers of rmsf. we collected ticks and examined them for bacterial pathogens using molecular methods to determine if a novel tick vector or spotted fever group rickettsiae (sfgr) might be emerging. amblyomma americanum, the lone star tick, comprised 99.6% of 6,502 specimens collected in suburban landscapes. in contrast, dermacen ... | 2008 | 18447622 |
| rickettsia rickettsii transmission by a lone star tick, north carolina. | only indirect or circumstantial evidence has been published to support transmission of rickettsia rickettsii by amblyomma americanum (lone star) ticks in north america. this study provides molecular evidence that a. americanum ticks can function, although most likely infrequently, as vectors of rocky mountain spotted fever for humans. | 2011 | 21529399 |
| seroepidemiologic study of human infections with spotted fever group rickettsiae in north carolina. | increasing entomologic and epidemiologic evidence suggests that spotted fever group rickettsiae (sfgr) other than rickettsia rickettsii are responsible for spotted fever rickettsioses in the united states. a retrospective seroepidemiologic study was conducted on stored acute- and convalescent-phase sera that had been submitted for rocky mountain spotted fever testing to the north carolina state laboratory of public health. we evaluated the serologic reactivity of the paired sera to r. rickettsii ... | 2014 | 25187639 |
| incident tick-borne infections in a cohort of north carolina outdoor workers. | tick-borne diseases cause substantial morbidity throughout the united states, and north carolina has a high incidence of spotted fever rickettsioses and ehrlichiosis, with sporadic cases of lyme disease. the occupational risk of tick-borne infections among outdoor workers is high, particularly those working on publicly managed lands. this study identified incident tick-borne infections and examined seroconversion risk factors among a cohort of north carolina outdoor workers. workers from the nor ... | 2016 | 27008102 |