| prolonged western equine encephalitis viremia in the texas tortoise (gopherus berlandieri). | subcutaneous inoculation of 34 texas tortoises (gopherus berlandieri) with either of two strains of western equine encephalitis (wee) virus resulted in prolonged viremia of up to 105 days' duration. peak viremia titers exceeded 10(6) suckling mouse intracranial lethal doses per milliliter. the length of the previremic period, the maximum viremia level attained, and the duration of viremia were markedly affected by environmental temperature. higher temperatures (30 degrees c) shortened the previr ... | 1977 | 842780 |
| hemoglobin polymorphism in the encinal mouse, peromyscus pectoralis. | horizontal starch gel electrophoresis revealed five hemoglobin phenotypes in natural populations of the encinal mouse, peromyscus pectoralis, from northeastern mexico. populations of the encinal mouse from texas, oklahoma, and northwestern and north central mexico were monomorphic for multiple-band phenotypes. analysis of the hemoglobin polymorphism indicates that two loci control this variation. | 1976 | 1259700 |
| naturally acquired rabies in an armadillo (dasypus novemcinctus) in texas. | the first case of rabies in an armadillo is reported. the rabies fluorescent-antibody test and mouse inoculation procedure were used to substantiate the presence of the virus. the centers for disease control authenticated our findings and was able to determine the source of infection by monoclonal antibody typing. | 1989 | 2643619 |
| leakey virus: a new hantavirus isolated from mus musculus in the united states. | a hantavirus, designated leakey virus, was isolated from a mus musculus captured in real county, texas, u.s.a. in august 1986. virus-specific fluorescence was first detected 13 days after inoculation of vero-e6 cells with spleen tissue from the seropositive m. musculus. ultrastructurally, the new isolate resembled other hantaviruses. leakey virus induced a fatal meningoencephalitis in infant fischer rats, with viral antigen detectable in brain, lung, liver, kidney and spleen. serum dilution, pla ... | 1988 | 3143810 |
| complement-fixation and hemagglutination antigens from a chlamydial (ornithosis) agent grown in cell cultures. | methods are described for the preparation of complement-fixation (cf) and hemagglutination (ha) antigens from the texas turkey ornithosis agent grown in mccoy cell culture monolayers. the particulate antigens prepared for this study were satisfactory for testing mammalian sera by direct cf tests and avian sera by indirect cf or modified direct cf tests. comparison of titers were made on human, bovine and ovine sera using direct cf tests employing antigen prepared for this study, 6 bc yolk sac an ... | 1970 | 4248445 |
| an outbreak of gastroenteritis due to a heat-labile enterotoxin-producing strain of escherichia coli. | in april 1981, an outbreak of gastroenteritis, characterized by diarrhea and abdominal cramps, occurred in 282 of approximately 3,000 personnel at a large metropolitan hospital in san antonio, tex. there was a significant association between illness and eating at the hospital cafeteria (p = 0.0008), but no specific food could be incriminated. stools or rectal swabs from 54 ill individuals produced almost pure cultures of escherichia coli. cultures from 51 of these subjects had identical antibiot ... | 1983 | 6350188 |
| malaria vaccine research. | in our report "activation of raf as a result of recruitment to the plasma membrane" (3 june, p. 1463) (1), panels e and f of figure 1 on page 1464 were incorrect. the correct photographs appear below. in addition, the [see figure in the pdf file] second sentence of the legend to figure 1 should have read, "the raf constructs were tagged at the cooh-terminus with a glu-glu epitope (meympme) (24) for c-raf, or at the nh(2)-terminus with both the glu-glu and the myc (meqkliseedl) (23) epitopes for ... | 1994 | 7864993 |
| coccidian parasites (apicomplexa) from snakes in the southcentral and southwestern united states: new host and geographic records. | four hundred thirty-five leptotyphlopid, colubrid, elapid, and viperid snakes were collected from various localities in arkansas, new mexico, oklahoma, and texas, and their feces were examined for coccidian parasites. of these, 131 (30%) were passing oocysts or sporocysts of at least 1 coccidian; 88 (67%) of the infected snakes had only 1 species of coccidian when they were examined. aquatic and semiaquatic snakes accounted for 48% of the infections, whereas strictly terrestrial snakes comprised ... | 1995 | 7876980 |
| prevalence of antibodies to arenaviruses in rodents from the southern and western united states: evidence for an arenavirus associated with the genus neotoma. | the objectives of this study were to extend our knowledge of the geographic distribution and rodent host range of arenaviruses in north america. sera from wild rodents collected from the southern and western united states were tested for antibody against tamiami, pichinde, junin, and lymphocytic choriomeningitis viruses, using an indirect fluorescent antibody test. antibody to at least one arenavirus was found in 220 (3.1%) of 7,106 rodents tested. the antibody-positive animals included mus musc ... | 1996 | 8686773 |
| cocirculation of multiple hantaviruses in texas, with characterization of the small (s) genome of a previously undescribed virus of cotton rats (sigmodon hispidus). | an environmental and laboratory investigation was conducted after a fatal childhood case of hantavirus pulmonary syndrome occurred in deaf smith county, texas in may 1995. a trapping campaign was conducted to identify possible rodent carriers. six species of murid and heteromyid rodents were collected, and at least one hantavirus-seropositive specimen was found in each of the five murid species. tissues from a selection of 11 seropositive specimens were examined by the polymerase chain reaction ... | 1996 | 9025697 |
| genetic heterogeneity of borrelia burgdorferi sensu lato in the southern united states based on restriction fragment length polymorphism and sequence analysis. | fifty-six strains of borrelia burgdorferi sensu lato, isolated from ticks and vertebrate animals in missouri, south carolina, georgia, florida, and texas, were identified and characterized by pcr-restriction fragment length polymorphism (rflp) analysis of rrf (5s)-rrl (23s) intergenic spacer amplicons. a total of 241 to 258 bp of intergenic spacers between tandemly duplicated rrf (5s) and rrl (23s) was amplified by pcr. msei and drai restriction fragment polymorphisms were used to analyze these ... | 2001 | 11427560 |
| molecular determinants of virulence of west nile virus in north america. | west nile virus (wnv) is a mosquito-borne flavivirus that until very recently had not been found in the americas. in 1999, there was an outbreak of west nile encephalitis in new york and surrounding areas, involving 62 human cases, including 7 fatalities. the virus has subsequently become established in the united states of america (u.s.) with 4156 human cases, including 284 deaths, in 2002. the wnv strains found in the u.s. are members of "lineage i", a genetic grouping that includes viruses fr ... | 2004 | 15119761 |
| emergence of attenuated west nile virus variants in texas, 2003. | in order to understand how west nile virus (wnv) has evolved since its introduction into north america, we have studied the genetic and phenotypic variation among wnv isolates collected in various areas during consecutive transmission seasons. the present report describes for the first time phenotypic changes occurring in the north american wnv population. several isolates collected in texas during 2003 display a small plaque (sp) and temperature sensitive (ts) phenotype, as well as reduced repl ... | 2004 | 15527859 |
| hantavirus pulmonary syndrome--five states, 2006. | hantavirus pulmonary syndrome (hps) is a rodentborne viral disease characterized by severe pulmonary illness and a case-fatality ratio of 30%-40%. sin nombre virus causes the majority of hps cases in the united states, and the deer mouse (peromyscus maniculatus) is its predominant reservoir. this report describes an increase in human cases of hps reported during january-march 2006 from arizona, new mexico, north dakota, texas, and washington state. the findings emphasize the need for renewed att ... | 2006 | 16760891 |
| possible vector dissemination by swift foxes following a plague epizootic in black-tailed prairie dogs in northwestern texas. | to determine whether swift foxes (vulpes velox) could facilitate transmission of yersinia pestis to uninfected black-tailed prairie dog (cynomys ludovicianus) colonies by acquiring infected fleas, ectoparasite and serologic samples were collected from swift foxes living adjacent to prairie dog towns during a 2004 plague epizootic in northwestern texas, usa. a previous study (1999-2001) indicated that these swift foxes were infested almost exclusively with the flea pulex irritans. black-tailed pr ... | 2006 | 16870868 |
| polyplax serrata (brumeister) and linognathus setosus (olfers) recorded from the house mouse, mus musculus linnaeus in texas. | | 1949 | 18133326 |
| species diversity and relative abundance of phlebotomine sand flies (diptera: psychodidae) on three army installations in the southern united states and susceptibility of a domestic sand fly to infection with old world leishmania major. | leishmania infections in american veterans of iraq and afghanistan have raised concern that veterans could serve as reservoirs of old world parasites for domestic vector populations. a survey of sand flies on three u.s. army facilities in the southern united states was conducted to identify potential vectors. five species, including two new state records, are reported for fort hood, tx. very few flies were detected in fort bragg, nc. large numbers of a man-biting species, lutzomyia shannoni, wer ... | 2009 | 19960830 |
| besnoitiosis in a southern plains woodrat (neotoma micropus) from uvalde, texas. | abstract recently, besnoitia neotomofelis was described from a southern plains woodrat (neotoma micropus) from southern texas. during may 2010, 1 of 55 southern plains woodrats trapped in uvalde county, texas was diagnosed with besnoitiosis. grossly, the woodrat had bilateral swellings of the cheeks and numerous besnoitia sp.-like cysts were observed in the tongue, facial region, musculature of the limbs, and subcutis of the dorsum and flanks. little to no inflammation was noted around cysts. th ... | 2011 | 21524194 |
| resistance to plague among black-tailed prairie dog populations. | abstract in some rodent species frequently exposed to plague outbreaks caused by yersinia pestis, resistance to the disease has evolved as a population trait. as a first step in determining if plague resistance has developed in black-tailed prairie dogs (cynomys ludovicianus), animals captured from colonies in a plague-free region (south dakota) and two plague-endemic regions (colorado and texas) were challenged with y. pestis at one of three doses (2.5, 250, or 2500 mouse ld50s). south dakota p ... | 2011 | 21923261 |
| current controversies in spondyloarthritis: spartan. | the spondyloarthritis research and therapy network (spartan), founded in 2003 to promote research, education, and treatment of ankylosing spondylitis (as) and related forms of spondyloarthritis (spa), held its 7th annual research and education meeting in july 2009 in houston, texas. current controversies in spa discussed during the meeting included an update on the epidemiology of as, axial spa, and inflammatory back pain; the adequacy of the msass to assess radiographic involvement; the helpful ... | 2010 | 21123334 |
| multiple pathways to the attenuation of west nile virus in south-east texas in 2003. | west nile virus (wnv) was first detected in texas in 2002. during 2003, several isolates exhibiting significant attenuation of mouse neuroinvasiveness, and in some cases a small plaque and temperature sensitive phenotype when compared to other north american wnv isolates, were obtained from birds and mosquitoes in south-east texas. to determine the attenuation markers of wnv, we have sequenced the genomes of three attenuated isolates and four temporally related virulent isolates and compared the ... | 2010 | 20580395 |
| identification of fda-approved drugs and bioactives that protect hair cells in the zebrafish (danio rerio) lateral line and mouse (mus musculus) utricle. | the hair cells of the larval zebrafish lateral line provide a useful preparation in which to study hair cell death and to screen for genes and small molecules that modulate hair cell toxicity. we recently reported preliminary results from screening a small-molecule library for compounds that inhibit aminoglycoside-induced hair cell death. to potentially reduce the time required for development of drugs and drug combinations that can be clinically useful, we screened a library of 1,040 fda-approv ... | 2009 | 19241104 |
| investigation and characterization of the frozen feeder rodent industry in texas following a multi-state salmonella typhimurium outbreak associated with frozen vacuum-packed rodents. | a multi-state outbreak investigation of salmonella typhimurim cases associated with pet snakes and the frozen vacuum-packed rodents used to feed them identified a texas frozen feeder rodent facility (supplier a) as the source of the salmonella-infected frozen rodents. texas authorities collected samples directly from supplier a. seven salmonella-positive samples out of 49 environmental swabs were found and one adult mouse out of 88 frozen feeder rodents was salmonella-positive by culture. no sal ... | 2008 | 18811909 |
| direct observation of computer workplace risk factors of college students. | recently, researchers have reported high musculoskeletal symptom prevalence at several us colleges. since ergonomic interventions have been shown to prevent and reduce disability, it is important to identify the risk factors for developing symptoms among college students. a nested case-control study was completed to determine computer-related ergonomic risks associated with musculoskeletal symptoms. a trained observer completed ergonomic assessments on 52 randomly selected cases and controls. mo ... | 2007 | 17264422 |
| mouse genetics. nih knocks out key mouse house. | | 2006 | 16809502 |
| fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. | fumonisins are a family of toxic and carcinogenic mycotoxins produced by fusarium verticillioides (formerly fusarium moniliforme), a common fungal contaminant of maize. fumonisins inhibit ceramide synthase, causing accumulation of bioactive intermediates of sphingolipid metabolism (sphinganine and other sphingoid bases and derivatives) as well as depletion of complex sphingolipids, which interferes with the function of some membrane proteins, including the folate-binding protein (human folate re ... | 2004 | 15051815 |
| evidence for linkage of postchallenge insulin levels with intestinal fatty acid-binding protein (fabp2) in mexican-americans. | single genes with large effects may contribute to insulin resistance or influence susceptibility to non-insulin-dependent diabetes mellitus (niddm). in the pima indians, results from sib-pair analysis have suggested that a gene on chromosome 4q influences both fasting insulin levels and maximal insulin action. we conducted sib-pair and logarithm of odds (lod)-score linkage analysis to seek evidence for linkage between genes influencing insulin levels and chromosome 4q loci. analyses were conduct ... | 1995 | 7657027 |
| laboratory studies of venezuelan equine encephalitis virus in equines, texas, 1971. | during the summer and fall of 1971, epizootic and epidemic venezuelan equine encephalitis was detected in texas. isolates of epizootic (ib) and vaccine (tc-83) strains were distinguished by virulence of the former for guinea pigs. vaccine virus was isolated from 1 to 14 days after vaccination and neutralization tests demonstrated the appearance of antibody about a week after vaccination. viremia titers of subtype ib in horses ranged from 2.2 to 8.3 log10 suckling mouse intracranial 50% lethal do ... | 1975 | 1176627 |
| virological and serological studies of venezuelan equine encephalomyelitis in humans. | during the 1971 epidemic of venezuelan equine encephalomyelitis (vee) in south texas, 203 suspect vee cases were evaluated by the center for disease control. sixty-seven were confirmed as cases of vee. laboratory confirmation was accomplished by isolation of vee virus from a serum specimen taken during the acute illness in 50 (75%) of the confirmed cases. serological confirmation was obtained in 17 cases (25%). virus isolations were most often obtained from sera collected during the first 3 days ... | 1976 | 956360 |
| john stehlin: holistic oncology and a nude mouse. | | 1979 | 372572 |
| histocompatibility-2 system of wild mice. iv. ia and ir typing of two wild mouse populations. | | 1977 | 330085 |
| southern plains woodrats (neotoma micropus) from southern texas are important reservoirs of two genotypes of trypanosoma cruzi and host of a putative novel trypanosoma species. | trypanosoma cruzi, the causative agent of chagas' disease, is an important public health and veterinary pathogen. although human cases are rare in the united states, infections in wildlife, and in some areas domestic dogs, are common. in 2008 and 2010, we investigated t. cruzi prevalence in possible vertebrate reservoirs in southern texas, with an emphasis on southern plains woodrats (neotoma micropus). infection status was determined using a combination of culture isolation, polymerase chain re ... | 2013 | 23127189 |
| polymorphisms of mdm4 and risk of squamous cell carcinoma of the head and neck. | purpose: mouse double minute 4 (mdm4), a homolog of mdm2, is one of the key negative regulators of p53, and its amplification or overexpression contributes to carcinogenesis by inhibiting the p53 tumor suppressor activity. we investigated the association between mdm4 polymorphisms and the risk of squamous cell carcinoma of the head and neck (scchn). methods: we genotyped three mdm4 tagging polymorphisms, two in the 3' untranslated region (rs11801299g>a and rs10900598g>t) and one in intron 1 (rs1 ... | 2011 | 21540763 |