| male meiosis and gametogenesis in wild house mice (mus musculus domesticus) from a chromosomal hybrid zone; a comparison between "simple" robertsonian heterozygotes and homozygotes. | wild male house mice mus musculus domesticus were collected from the hybrid zone between the john o'groats race (2n = 32) and the standard race (2n = 40) in northern scotland. meiosis in both homozygotes (2n = 32, 36, and 40) and single robertsonian heterozygotes (2n = 33, 35, and 37) was found to be orderly. at prophase/metaphase i in heterozygotes, a trivalent was formed from the metacentric and two homologous acrocentrics. at pachytene, this trivalent usually had a single side arm at the posi ... | 1992 | 1424812 |
| regulation of leishmania populations within the host. v. resistance to l.donovani in wild mice. | samples of wild mus musculus from two populations in areas endemic for leishmaniasis and from seven populations in non-endemic areas were found to be uniformly resistant when tested for their early response to leishmania donovani infection. males from one endemic and one non-endemic population were crossed to females from two inbred strains of mice carrying the susceptible allele for the innate resistance gene, lsh, on different genetic backgrounds. bimodality of liver parasite counts and a clos ... | 1983 | 6854699 |
| association study of the cacn1a4 (sca6) triplet repeat and schizophrenia. | the p/q type ca2+ channel alpha 1-subunit (cacn1a4) gene on chromosome 19p13 is a promising candidate susceptibility locus for schizophrenia. point mutations in cacn1a4 cause familial hemiplegic migraine and episodic ataxia. expansion in a coding 3' cag repeat causes spino-cerebellar ataxia type 6 (sca6). the mouse mutant phenotype totterer has a form of petit-mal epilepsy. these are neurological conditions, all of which exhibit features in common with schizophrenia. the 19p13 area is also paral ... | 1999 | 10412193 |
| genetic determinants of hair and eye colours in the scottish and danish populations. | eye and hair colour is highly variable in the european population, and is largely genetically determined. both linkage and association studies have previously been used to identify candidate genes underlying this variation. many of the genes found were previously known as underlying mutant mouse phenotypes or human genetic disease, but others, previously unsuspected as pigmentation genes, have also been discovered. | 2009 | 20042077 |
| origin of an insular population of the wood mouse based on parasitological evidence. | parasitological data were used to test the hypothesis that the wood mouse (apodemus sylvaticus) population of fair isle, shetland, originated from the british isles rather than scandinavia, as is usually argued. this study was based on the assumption that the mice were likely to share most of their parasite fauna with conspecifics from their ancestral home. the ecto- and endo-parasites of wood mice on fair isle between 18 june to 10 july 1987 and 17 to 26 august 1991 were identified and compared ... | 1998 | 9476237 |
| robertsonian translocations in mus musculus from n. e. scotland and orkney. | | 1982 | 7107309 |
| caithness revisited: robertsonian chromosome polymorphism in caithness house mice. | the purpose of this communication is to revise and clarify the position regarding house mouse populations with robertsonian chromosomes in the northern scottish county of caithness. | 1990 | 2312343 |
| a hybrid zone comprising staggered chromosomal clines in the house mouse (mus musculus domesticus). | in the vicinity of john o'groats (caithness, scotland) there is a small karyotypic race of the house mouse (mus musculus domesticus) characterized by a diploid number of 32 chromosomes, including the metacentrics 4.10, 9.12, 6.13 and 11.14. this race forms a hybrid zone with the standard british race (fully acrocentric chromosomes, 2n = 40). although hybrid zones normally consist of several (or many) narrow character clines at the same position, this zone is unusual in that the chromosomal cline ... | 1991 | 1684667 |
| a new escherichia coli o-group, o159, associated with outbreaks of enteritis in infants. | an outbreak of enteritis occurred amongst babies in a nursery unit. 25 babies were affected and 5 required intravenous therapy; there were not fatalities. from 24 of the 25 babies affected, an escherichia coli with a previously undescribed o-antigen was isolated. an outbreak of diarrhoea had taken place in the same hospital a year before and re-examiniation of cultures of e. coli isolated at that time showed that 5 of the 15 babies affected had been excreting e. coli with the same o-antigen. iso ... | 1976 | 788145 |
| a threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. | markers at the pericentriolar material 1 gene (pcm1) have shown genetic association with schizophrenia in both a university college london (ucl) and a usa-based case-control sample. in this paper we report a statistically significant replication of the pcm1 association in a large scottish case-control sample from aberdeen. resequencing of the genomic dna from research volunteers who had inherited haplotypes associated with schizophrenia showed a threonine to isoleucine missense mutation in exon ... | 2010 | 19048012 |
| of mice and (viking?) men: phylogeography of british and irish house mice. | the west european subspecies of house mouse (mus musculus domesticus) has gained much of its current widespread distribution through commensalism with humans. this means that the phylogeography of m. m. domesticus should reflect patterns of human movements. we studied restriction fragment length polymorphism (rflp) and dna sequence variations in mouse mitochondrial (mt) dna throughout the british isles (328 mice from 105 localities, including previously published data). there is a major mtdna li ... | 2009 | 18826939 |
| surveillance of algal toxins in shellfish from scottish waters. | shellfish samples were collected from coastal and offshore aquaculture sites and harvesting areas in scottish waters between march 2003 and september 2004. samples were analysed for the presence of algal toxins using traditional mouse bioassays for the detection of paralytic shellfish poisoning (psp) toxins and diarrhetic shellfish poisoning (dsp) toxins; immuno-lateral flow chromatography for the detection of psp toxins in the form of the jellett rapid test; high-performance liquid chromatograp ... | 2008 | 18207483 |
| a comparison of the mouse bioassay with liquid chromatography-mass spectrometry for the detection of lipophilic toxins in shellfish from scottish waters. | some lipophilic shellfish toxins (lsts) can cause human illness due to eating shellfish that have become naturally contaminated following filter feeding on toxin producing algae. a mouse bioassay (mba) is widely used to detect lsts in regulatory monitoring of shellfish. however, the mba is imprecise giving only a positive or negative result and is prone to interference from other compounds. in this study, liquid chromatography-mass spectrometry (lc-ms) was compared to the mba, with the aim of su ... | 2007 | 17499325 |
| magnetic resonance imaging-the aberdeen perspective on developments in the early years. | from the beginnings of medical imaging with radioactivity, an account is given of the development in aberdeen of ct scanners in nuclear medicine, and their clinical value, leading to the present-day gamma-cameras. early animal work with electron magnetic resonance is described, which developed into a programme towards nuclear magnetic resonance of water in body tissues. the 1974 nmr image of a mouse, using the nuclear medicine experience, led to a quest to build the first clinically useful whole ... | 2006 | 16790917 |
| variation in the long-tailed field-mouse (apodemus sylvaticus (l.)) in north-west scotland. ii. simultaneous examination of all characters. | | 1964 | 14224408 |
| variation in the long-tailed field-mouse (apodemus sylvaticus (l.)) in north-west scotland. i. comparisons of individual characters. | | 1964 | 14224407 |
| the effect of multiple simple robertsonian heterozygosity on chromosome pairing and fertility of wild-stock house mice (mus musculus domesticus). | the influence of robertsonian (rb) heterozygosity on fertility has been the subject of much study in the house mouse. however, these studies have been largely directed at single simple heterozygotes (heterozygous for a single rb metacentric) or complex heterozygotes (heterozygous for several to many metacentrics which share common chromosome arms). in this paper we describe studies on male multiple simple heterozygotes, specifically the f(1) products of crosses between wild-stock mice homozygous ... | 2002 | 12438809 |
| paratuberculosis infection of nonruminant wildlife in scotland. | recent reports of natural paratuberculosis (or johne's disease) in rabbits, foxes, and stoats has focused debate on the presence and importance of wildlife reservoirs in the epidemiology of this disease. this paper describes an extensive study investigating 18 nonruminant wildlife species for evidence of paratuberculosis. using both culture and histopathological analysis, fox, stoat, weasel, crow, rook, jackdaw, rat, wood mouse, hare, and badger were found to harbor mycobacterium avium subsp. pa ... | 2001 | 11283080 |