| virus-like particle, 35 to 40 nm, associated with an institutional outbreak of acute gastroenteritis in adults. | in an outbreak of acute gastroenteritis in an institution for the mentally retarded at otofuke, hokkaido, japan, virus-like particles were observed by electron microscopy in five of seven stool specimens from the patients. the particles had 10 rod-shaped and 10 round projections or capsomeres on the periphery, measured 35 to 40 nm in diameter, and had a buoyant density of 1.35 to 1.37 g/ml in cesium chloride. attempts to culture these particles in tissue culture or in mouse brain were unsuccessf ... | 1979 | 94599 |
| epidemiological studies of hemorrhagic fever with renal syndrome (hfrs) related virus infection among urban rats in hokkaido, japan. | seroepidemiological studies of hemorrhagic fever with renal syndrome (hfrs) virus infection were carried out among urban rats (rattus norvegicus and rattus rattus) and small field rodents in hokkaido, japan. an urban rat colony that was seropositive to sr-11 strain of hfrs virus (laboratory rat origin) was demonstrated in february 1983 at a dumping ground area of kami-iso town near hakodate port. an hfrs-related virus, named ki-262 strain, was isolated from the lung tissue of a seropositive rat ... | 1986 | 2871823 |
| eimerians from different karyotypes of the japanese wood mouse (apodemus spp.), with descriptions of two new species and a redescription of eimeria montgomeryae lewis and ball, 1983. | examination of 131 wood mice (apodemus spp.) representing 2 species and 6 subspecies collected from the japanese islands of hokkaido, honshu, kyushu, and tsushima showed that 70 mice (53%) had coccidian oocysts in their feces. these included 21 of 42 (50%) apodemus argenteus argenteus; 7 of 14 (50%) apodemus argenteus hokkaidi; 2 of 3 (67%) apodemus argenteus sagax; 3 of 9 (33%) apodemus speciosus ainu; 36 of 61 (59%) apodemus speciosus speciosus; and 1 of 2 (50%) apodemus speciosus tusimaensis. ... | 1985 | 4093813 |
| mixed infection of different borrelia species among apodemus speciosus mice in hokkaido, japan. | the wood mouse (apodemus speciosus) serves as a wildlife reservoir for lyme disease spirochetes in hokkaido, japan. to isolate borrelia species, we captured 34 wood mice in an area where borrelia species are endemic during october 1993. the earlobes (right and left), heart, spleen, and urinary bladder from each mouse were used as culture sources. as a result of culture 73 isolates from 21 mice were classified by rrna gene restriction fragment length polymorphism analysis. ribotype groups iii (bo ... | 1995 | 7536218 |
| infectivity and early antibody response to borrelia burgdorferi sensu lato isolated in japan in outbred mice. | borrelia burgdorferi sensu lato isolated from ixodes ovatus (b. japonica), i. persulcatus and patients with erythema migrans (em) in japan were determined on infectivity and arthritis induction-activity in outbred mice. infectivity of b. japonica was weak and did not induce the development of footpad swelling by subcutaneous (s.c.) inoculation into the footpad. challenged strain, no129-m of b. japonica, to ddy mice were reinoculated to the mice at various cell numbers (1 x 10-1 x 10(6) cells/mou ... | 1994 | 7799835 |
| in vitro and in vivo antibiotic susceptibility of lyme disease borrelia isolated from the ixodid tick in japan. | antimicrobial susceptibility of the lyme disease borrelia, strain hp1 vi, isolated from the tick ixodes persulcatus in hokkaido, japan, was determined in vitro and in vivo. a broth dilution technique was used to determine the minimum inhibitory concentrations (mics) and minimum borreliacidal concentrations (mbcs) of five antimicrobial agents. strain hp1 vi was most susceptible to minocycline (mbc, 0.2 micrograms/ml). the other antimicrobial agents tested, aspoxicillin, cefmetazole sodium, imipen ... | 1995 | 8648001 |
| pathogenicity of tick-borne encephalitis virus isolated in hokkaido, japan in mouse model. | the pathogenic characteristics of tick-borne encephalitis (tbe) virus strain (oshima 5-10) isolated from a sentinel dog in hokkaido, japan, was compared by use of a mouse model with several inoculation routes to other strains of tbe virus (the far eastern subtype; sofjin strain and the western subtype; hochosterwitz strain) and tbe complex virus (langat virus; tp-21 strain). the degree of neuroinvasiveness of the strains in mice subcutaneously (s.c.) inoculated was sofjin equaled hochosterwitz w ... | 1999 | 10067683 |
| phylogenetic and virulence analysis of tick-borne encephalitis viruses from japan and far-eastern russia. | we have previously reported that tick-borne encephalitis (tbe) is endemic in a specific area of hokkaido, japan. in oshima, the southern part of hokkaido, tbe virus was isolated from sentinel dogs, ticks and rodents in 1995 and 1996. to identify when these tbe viruses emerged in hokkaido, the times of divergence of tbe virus strains isolated in oshima and far-eastern russia were estimated. tbe virus was isolated in khabarovsk in 1998 and the nucleotide sequences of viral envelope protein genes o ... | 1999 | 10567643 |
| japanese scrapie cases. | worldwide attention has been given to scrapie, because bovine spongiform encephalopathy (bse) could be experimentally transmitted to sheep. this ovine form of bse was clinically identical to scrapie. in japanese scrapie cases, a majority of the diseased sheep were from suffolk, while 8 cases were from corriedale. it is very likely that sheep-to-sheep transmission of scrapie has taken place in obihiro, hokkaido. normal prion protein may play a role in the morphoregulatory signaling pathway, which ... | 2000 | 10871915 |
| epidemiology of tick-borne encephalitis (tbe) and phylogenetic analysis of tbe viruses in japan and far eastern russia. | in oshima, the southern part of hokkaido, a tick-borne encephalitis (tbe) patient was found in 1993; in addition tbe virus was isolated from the blood samples of sentinel dogs, ticks pools, and rodents spleens in 1995 and 1996 by suckling mice. to identify when these tbe viruses emerged in hokkaido, the times of divergence of tbe virus strains isolated in oshima and far eastern russia were estimated. tbe virus was isolated in khabarovsk in 1998, and the nucleotide sequences of viral envelope pro ... | 2001 | 11326122 |
| differential geographic patterns of mitochondrial dna variation in two sympatric species of japanese wood mice, apodemus speciosus and a. argenteus. | we examined the gene sequences of mitochondrial cytochrome b (cyt b) in two japanese wood mouse species, apodemus speciosus (n = 89) and a. argenteus (n = 46), which are distributed on the four main islands of japan (hokkaido, honshu, shikoku, and kyushu) and on the small islands surrounding them. apodemus speciosus, the larger of the two species, showed substantial genetic variation, with a maximum of 3% sequence divergence, and remarkable phylogenetic subdivision with two major clades. one cla ... | 2004 | 15329497 |
| phylogeographic origin of hokkaido house mice (mus musculus) as indicated by genetic markers with maternal, paternal and biparental inheritance. | we examined intraspecies genetic variation in house mice (mus musculus molossinus) from the northern third of the japanese islands, in order to obtain evidence of the history of mouse colonization that might have shaped the current genetic diversity. we extended the previous sampling of mitochondrial cytochrome b sequence and added information from the y-linked sry gene and ribosomal rna gene surveys. we distinguish mitochondrial haplotypes characteristic of the north asian musculus subspecies g ... | 2006 | 16391552 |
| [lipophilic toxin profiles associated with diarrhetic shellfish poisoning in scallops, patinopecten yessoensis, collected in hokkaido and comparison of the quantitative results between lc/ms and mouse bioassay]. | lipophilic toxins associated with diarrhetic shellfish poisoning (dsp) in scallops, patinopecten yessoensis, collected in hokkaido, japan were quantified by liquid chromatography-mass spectrometry (lc/ms). pectenotoxin-6 (ptx6) and yessotoxin (ytx) were the dominant toxins in the scallops, although the percentages of these toxins were different depending on the production area or the sampling period. the quantitative results obtained for the scallops in lc/ms and in mouse bioassay (mba) were com ... | 2006 | 16729662 |
| a trend of central versus peripheral structuring in mitochondrial and nuclear gene sequences of the japanese wood mouse, apodemus speciosus. | a phylogeographic analysis was performed on japanese endemic wood mice (apodemus speciosus) using nuclear interphotoreceptor retinol binding protein (irbp) gene sequences (1,152 bp), together with previously published mitochondrial cytochrome b (cyt b) data. in the irbp analysis, 40 haplotypes were recovered from 84 individuals by statistical and subcloning methods. substantial sequence variation was determined from the irbp data (pi=0.0047), and no significant evidence of recombination was dete ... | 2008 | 18393564 |
| Interspecific Differences in Tannin Intakes of Forest-Dwelling Rodents in the Wild Revealed by a new Method Using Fecal Proline Content. | Mammalian herbivores adopt various countermeasures against dietary tannins, which are among the most widespread plant secondary metabolites. The large Japanese wood mouse Apodemus speciosus produces proline-rich salivary tannin-binding proteins in response to tannins. Proline-rich proteins (PRPs) react with tannins to form stable complexes that are excreted in the feces. Here, we developed a new method for estimating the tannin intake of free-living small rodents, by measuring fecal proline cont ... | 2011 | 22161223 |
| environmental dna enables detection of terrestrial mammals from forest pond water. | terrestrial animals must have frequent contact with water to survive, implying that environmental dna (edna) originating from those animals should be detectable from places containing water in terrestrial ecosystems. aiming to detect the presence of terrestrial mammals using forest water samples, we applied a set of universal pcr primers (mimammal, a modified version of fish universal primers) for metabarcoding mammalian edna. the versatility of mimammal primers was tested in silico and by ampli ... | 2017 | 28603873 |