| malaria among puerto rican veterans of the viet nam conflict. | | 1967 | 5342620 |
| evaluation of the flora of puerto rico for in vitro antiplasmodial and antimycobacterial activities. | the emergence of resistant strains of plasmodium falciparum and mycobacterium tuberculosis underscores the need for novel drugs that are effective against these microorganisms. as part of our screening programme of the flora of puerto rico, we tested a number of ethanol extracts of higher plants for antiplasmodial and antimycobacterial activities. a total of 40 extracts belonging to 23 plant families and 37 species were tested for antiplasmodial activity. five extracts demonstrated activity agai ... | 2001 | 11746852 |
| briarellins j-p and polyanthellin a: new eunicellin-based diterpenes from the gorgonian coral briareum polyanthes and their antimalarial activity. | a new chemical study of the hexane extract of the gorgonian briareum polyanthes collected in puerto rico afforded 10 new diterpenes of the eunicellin class, briarellins 1-9 and polyanthellin a (10), along with the known diterpene briarellin d (11). the structures and relative stereochemistry of metabolites 1-10 were assigned on the basis of nmr studies, chemical methods, and comparisons to the spectral properties of 11. a reassessment of prior structural assignment for briarellin a and two known ... | 2003 | 12662092 |
| plakortides m and n, bioactive polyketide endoperoxides from the caribbean marine sponge plakortis halichondrioides. | from a small specimen of the marine sponge plakortis halichondrioides collected in puerto rico we have isolated the known unsaturated ester methyl (2z,6r,8r,9e)-3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate (1) along with the known cyclic peroxide plakortide f (2). in addition, the structures of two new polyketide endoperoxides, namely, plakortide o (3) and plakortide p (4), were fully characterized by spectroscopic and chemical methods. the absolute stereochemistry of plakortide o methyl ester ... | 2003 | 12762801 |
| sesquiterpenoid metabolites with antiplasmodial activity from a caribbean gorgonian coral, eunicea sp. | a chemical investigation of the caribbean gorgonian octocoral eunicea sp. collected along the northwest coast of puerto rico has afforded seven new secondary metabolites, 1-7, belonging to several types of sesquiterpenes, including elemane, eudesmane, and germacrane types, along with the known steroidal glycoside 8. some of the new metabolites, 4-7, carry an unusual ester side chain at the c-6 position. the structures of all compounds, including their relative stereochemistry, were determined by ... | 2005 | 16180813 |
| bioactive compounds from the gorgonian briareum polyanthes. correction of the structures of four asbestinane-type diterpenes. | our extended chemical investigation of the crude meoh-chcl3 extract of the gorgonian octocoral briareum polyanthes from puerto rico has led to the isolation of three eunicellin-type diterpenoids, 1-3, along with five (4-8) diterpenoids of the asbestinane-type and one (9) of the briarane-type of polycyclized diterpenes. the structures and relative stereochemistry of the new compounds 1-9 were established on the basis of spectroscopic analysis (1h nmr, 13c nmr, hmqc, hmbc, noesy). the biological a ... | 2006 | 17190449 |
| bioactive cycloperoxides isolated from the puerto rican sponge plakortis halichondrioides. | two new five-membered-ring polyketide endoperoxides, epiplakinic acid f methyl ester (1) and epiplakinidioic acid (3), and a peroxide-lactone, plakortolide j (2), were isolated from the puerto rican sponge plakortis halichondrioides, along with two previously reported cyclic peroxides, 4 and 5. the structures of the new metabolites were determined by spectroscopic and chemical analyses. the absolute stereostructures of 1, 2, and 5 were determined by degradation reactions followed by application ... | 2010 | 20923180 |
| molecular characterization of a cluster of imported malaria cases in puerto rico. | the caribbean island of hispaniola is targeted for malaria elimination. currently, this is the only island with ongoing transmission of malaria in the caribbean. in 2015, six patients from puerto rico and one from massachusetts, who traveled to punta cana, dominican republic, were confirmed to be infected with plasmodium falciparum. additional molecular analysis was performed at the centers for disease control and prevention to characterize the drug-resistant alleles and plasmodium population ge ... | 2017 | 28749761 |