| prospective double-blind trial of two different doses of mefloquine plus pyrimethamine-sulfadoxine compared with pyrimethamine-sulfadoxine alone in the treatment of falciparum malaria. | this double-blind study is based on the treatment of 75 adult male patients suffering from plasmodium falciparum malaria in medellín, colombia, a city in which there is no malaria transmission. the patients, who came from regions with high resistance to antimalarials, were divided into three groups receiving single-dose treatment as follows: a combination of 280 mg mefloquine, 800 mg sulfadoxine and 40 mg pyrimethamine; a combination of 420 mg mefloquine, 1200 mg sulfadoxine and 60 mg pyrimetham ... | 1985 | 3910296 |
| susceptibility of different populations of colombian aotus monkeys to the fcb-1 strain of plasmodium falciparum. | p6udies of susceptibility to the fcb-1 strain of plasmodium falciparum from colombia were conducted in three different groups of aotus monkeys. the results indicated that aotus trivirgatus griseimembra from the north of the magdalena valley were the most susceptible host. a. t. griseimembra from the central magdalena valley appeared to be less susceptible to infection, while aotus monkeys from the eastern andes were even more resistant to infection. serum electrophoretic studies were not useful ... | 1984 | 6385739 |
| a clinical trial with halofantrine on patients with falciparum malaria in colombia. | a total of 120 semi-immune adult male malaria patients from an area of multidrug-resistant plasmodium falciparum malaria were hospitalized for 42 days in medellin, colombia (an area of no malaria transmission), and treated with halofantrine in a double-blind, randomized, prospective clinical trial according to five different treatment schedules. each patient was assigned to one of the following halofantrine schedules: i, one dose of 1000 mg; ii, three doses of 500 mg; iii, two doses of 500 mg; i ... | 1996 | 9060219 |
| [resistance of plasmodium falciparum to 3 antimalarials in turbo (antioquia, colombia), 1998]. | in 1998 we determined in vivo and in vitro the frequency and the degree of resistance of plasmodium falciparum to the three antimalarials (chloroquine, amodiaquine, and sulfadoxine/pyrimethamine) most utilized in the municipality of turbo (in the area of urabá, antioquia, colombia), in a sample representative of the population with malaria. we carried out clinical and parasitological analyses over a 14-day period using the standard test recommended by the world health organization. in vivo, p. f ... | 2001 | 11253274 |
| resistance of plamodium falciparum to antimalarial drugs in zaragoza (antioquia, colombia), 1998. | plasmodium falciparum sensitivity to chloroquine (chl), amodiaquine (amo) and sulfadoxine/pyrimethamine (sdx/pyr) was assessed in vivo and in vitro in a representative sample from the population of zaragoza in el bajo cauca region (antioquia-colombia). there were 94 patients with p. falciparum evaluated. for the in vivo test the patients were followed by clinical examination and microscopy, during 7 days. the in vitro test was performed following the recommendations of the world health organizat ... | 2002 | 12048572 |
| [comparison between optimal and the thick smear tests for malaria diagnosis in an endemic area during a non-epidemic period]. | the capacity of optimal to diagnose malaria was compared with the thick smear test in two representative samples, one with acute febrile syndrome (afs) n = 107, and another diagnosed by thick smear test (afs + m) n = 82. the samples were chosen from patients at the malaria diagnostic clinic in turbo, antioquia, colombia, between june and august 2000. the study was designed to be descriptive, prospective, and cross-sectional. the two tests were applied simultaneously in the afs group (parallel, d ... | 2002 | 12596444 |
| [therapeutic efficacy of 3 treatment protocols for non-complicated plasmodium falciparum malaria, antioquia, colombia, 2002]. | high resistance of plasmodium falciparum malaria to chloroquine poses malaria as a major public health problem in colombia. in this context, the therapeutic response of uncomplicated p. falciparum malaria patients to chloroquine (cq), sulfadoxine/pirymethamine (sdxp) and combined therapy (sdxp/cq) was evaluated according to the who/paho protocols of 1998. the comparisons were based on a sample of 160 patients with uncomplicated p. falciparum malaria in turbo and zaragoza (antioquia, colombia). p ... | 2003 | 14582335 |
| [gametocyte levels in response to differing malaria treatments in two municipalities of colombia]. | plasmodium falciparum gametocyte levels are influenced by level of regional endemicity, the antimalarial treatment, and the therapeutic response of patients. few previous studies have related these factors in colombia. here, gametocytaemia was evaluated with respect to two treatment schemes (sulfadoxine/pyrimethamine and sulfadoxine/pyrimethamine plus chloroquine), the patient response (adequate or failure), and the locality (two areas of varying case frequency). one hundred forty-eight resident ... | 2004 | 15239604 |
| nosocomial plasmodium falciparum infections confirmed by molecular typing in medellín, colombia. | three cases of nosocomial malaria are reported from patients of the internal medicine ward of a tertiary university teaching hospital in medellin, colombia. epidemiological research, based on entomological captures, medical records review and interviews of nursery staff about patient care practices potentially involving contact with blood, were carried out. molecular characterization of plasmodium falciparum was based on the amplification of msp1, msp2 and glurp genes. this method enabled confir ... | 2005 | 15703072 |
| [blood levels of sulfadoxine and pyrimethamine, according to the malaria-treatment response, in two municipalities of antioquia, colombia]. | there has been a constant increase in the level of therapeutic failure of the sulfadoxine-pyrimethamine (sp) combination for treating uncomplicated plasmodium falciparum malaria. | 2005 | 16156957 |
| therapeutic efficacy test in malaria falciparum in antioquia, colombia. | evaluate the frequency of failure of eight treatments for non-complicated malaria caused by plasmodium falciparum in patients from turbo (urabá region), el bagre and zaragoza (bajo cauca region), applying the 1998 protocol of the world health organization (who). monotherapies using chloroquine (cq), amodiaquine (aq), mefloquine (mq) and sulphadoxine-pyrimethamine (sp), and combinations using chloroquine-sulphadoxine-pyrimethamine (cq-sp), amodiaquine-sulphadoxine-pyrimethamine (aq-sp), mefloquin ... | 2006 | 16504002 |
| [assessment of the efficacy of antimalarial drugs in tarapacá, in the colombian amazon basin]. | the current antimalarial drug policy in colombia has been based on studies conducted in antioquia and the pacific coast. however, the efficacy of antimalarial drugs in other endemic regions is unknown. | 2007 | 17546230 |
| [polymorphisms of the pfmdr1 gene in field samples of plasmodium falciparum and their association with therapeutic response to antimalarial drugs and severe malaria in colombia]. | the pfmdr1 gene of plasmodium falciparum has been described as a gene conferring resistance to several antimalarial drugs. in particular, polymorphisms on specific codons have been associated with resistance and treatment failure with cloroquine, amodiaquine and mefloquine. however, the role of these polymorphisms in treatment response to antimalarials remains unexplored in colombia. furthermore, the relationship of these polymorphisms to severe malaria is unknown. | 2007 | 17713631 |
| [evaluation of ict malaria immunochromatographic binax now ict p.f/p.v test for rapid diagnosis of malaria in a colombian endemic area]. | one of the strategies to reduce malarial morbidity and mortality is to make an early diagnosis, using simple rapid tests which are highly sensitive and specific. furthermore, the tests must be easy to perform and understand by local people in such a way that a suitable and prompt antimalarial treatment is guaranteed. | 2007 | 17713633 |
| [gametocytemia in falciparum malaria treated with amodiaquine or artesunate]. | antimalarial treatment effects on plasmodium falciparum gametocytemia has been the focus of few studies in the americas. | 2008 | 18719722 |
| near-fixation of a pfmsp1 block 2 allelic variant in genetically diverse plasmodium falciparum populations across western colombia. | assessment of the genetic diversity of plasmodium falciparum in 110 colombian isolates revealed that nearly all the parasites in the 97 isolates collected in endemic regions west of the andes shared the same pfmsp1 block 2 mad20-type allelic variant, despite showing high diversity for other genetical markers. analysis of published data indicated that the prevalence of this allelic variant of a major vaccine candidate antigen was already dominant since 1998. this phenomenon, which had not been hi ... | 2010 | 20060375 |
| species composition and natural infectivity of anthropophilic anopheles (diptera: culicidae) in the states of córdoba and antioquia, northwestern colombia. | malaria is a serious health problem in the states of córdoba and antioquia, northwestern colombia, where 64.4% of total colombian cases were reported in 2007. because little entomological information is available in this region, the aim of this work was to identify the anopheles species composition and natural infectivity of mosquitoes distributed in seven localities with highest malaria transmission. a total of 1,768 anopheles mosquitoes were collected using human landing catches from march 200 ... | 2009 | 20140372 |
| origin and dissemination across the colombian andes mountain range of sulfadoxine-pyrimethamine resistance in plasmodium falciparum. | the therapeutic efficacy of sulfadoxine-pyrimethamine (sp) in treating uncomplicated plasmodium falciparum malaria is unevenly distributed in colombia. the andes mountain range separates regions in the west where malaria is endemic from those in the east and constitutes a barrier against gene flow and the dispersal of parasite populations. the distribution of dhfr and dhps genotypes of 146 p. falciparum samples from the eastern amazon and orinoco basins and northwest and southwest pacific region ... | 2010 | 20498318 |
| dynamics of plasmodium falciparum parasitemia regarding combined treatment regimens for acute uncomplicated malaria, antioquia, colombia. | selecting suitable anti-malarial treatment represents one of the best tools for reducing morbidity and mortality caused by this disease. sexual and asexual parasite dynamics were thus evaluated in patients involved in antimalarial drug efficacy studies by using combined treatment with and without artemisinin derivatives for treating uncomplicated acute plasmodium falciparum malaria in antioquia, colombia. all treatment doses were supervised and administered according to patients' weight; sexual ... | 2010 | 20595483 |