| frequency of the asn-108 and thr-108 point mutations in the dihydrofolate reductase gene in plasmodium falciparum from southwest colombia. | several point mutations in the dihydrofolate reductase (dhfr) gene of plasmodium falciparum have been correlated with in vitro anti-folate drug resistance of laboratory and field isolates. furthermore, two different point mutations that generate amino acid substitutions at the same position of the enzyme have been observed in all the isolates studied to date. these point mutations change a serine (ser-108) in the wild type to an asparagine (asn-108 mutation) or to a threonine (thr-108 mutation). ... | 1998 | 9684639 |
| [concordance between thick blood smear, immunochromatography and polymerase chain reaction for malaria diagnosis]. | the rapid and effective diagnosis of malaria is the determining condition for an appropriate treatment and control of the disease. | 2008 | 18719728 |
| assessment of therapeutic response of plasmodium vivax and plasmodium falciparum to chloroquine in a malaria transmission free area in colombia. | in order to determine the frequency of therapeutic failures to chloroquine (cq) in patients with malaria due to either plasmodium falciparum or p. vivax, and to explore the usefulness of a malaria-free city as a sentinel site to monitor the emergence of drug resistance, 53 patients (44 infected with p. vivax and 9 with p. falciparum) were evaluated at the laboratory of parasitology, universidad del valle in cali, colombia. patients received 25 mg/kg of cq divided in three doses over 48 h; they w ... | 2002 | 12118291 |