| application of the indirect fluorescent antibody method in a study of malaria endemicity in mato grosso, brazil. | four surveys of malaria endemicity were conducted in the cuiabá sector of mato grosso state, brazil, at 6-month intervals during the period april 1970 to september 1971; during april 1970 a survey was also conducted in the campo grande sector. over 4,000 dual specimens--blood films for parasite diagnosis and filter paper blood spots for determination of fluorescent antibody (ifa) response--were collected from the general population, including school populations whenever possible. parasitologic e ... | 1975 | 1098491 |
| some observations on the mosquitoes of indian settlements in xingu national park, mato grosso state, brazil, with emphasis on malaria vectors. | a mosquito survey was carried out in malarious indian settlements in the xingu national park, brazil, by the end of the rainy season--march, 1987, when 27 species were collected. an. darlingi, the most frequent an anthropophilic mosquito, was found infected with p. falciparum and seems to be the principal malaria vector in the area. the other anophelinae and culicinae were little frequent or scarce. the local fauna includes vectors of yellow fever and of several other arbovirus. | 1989 | 2575265 |
| [migratory flow of cases of malaria in cuiabá/mt, 1986]. | | 1988 | 3065909 |
| chloroquine resistance of plasmodium falciparum in brazil detected by a simple in vitro method. | the sensitivity of plasmodium falciparum to antimalarial drugs is primarily determined by observing changes in the level of parasitaemia after administration of drugs to man. performance of such a study and interpretation of its results may present certain difficulties, especially when conducted among persons living in malarious areas. the present study was conducted to evaluate the usefulness of a simple in vitro method for detecting chloroquine-resistant strains among infected residents of mat ... | 1971 | 4945631 |
| antibody responses to plasmodium falciparum sporozoite-, liver- and blood-stage synthetic peptides in migrant and autochthonous populations in malaria endemic areas. | this study evaluates the differences in host immune responses to defined plasmodial antigens in four geographically different regions in which malaria is endemic. sera from 527 individuals were tested for the presence of antibodies specific for three types of plasmodial antigen: liver-stage antigen (lsa-1), blood-stage antigen (spf 70) and circumsporozoite (cs) antigen (nanp)4. the individuals taking part in the study comprised: patients with transfusional malaria due to plasmodium falciparum or ... | 1995 | 9137641 |
| characterization of plasmodium falciparum isolated from the amazon region of brazil: evidence for quinine resistance. | the prevalence and severity of drug-resistant malaria is emerging rapidly in the amazon basin of brazil. in support of clinical trials using the new antimalarial drug combination of atovaquone and proguanil, we performed in vitro drug sensitivities, molecular characterization of parasite populations using the circumsporozoite protein, merozoite surface antigen-1 (msa-1), and msa-2 markers, and an analysis of the plasmodium falciparum multidrug resistance (pfmdr1) gene sequence and copy number in ... | 1998 | 9598453 |
| [malaria in the region of campinas, são paulo, brazil, 1980 to 1994]. | according to epidemiological data, from 1980 to 1994, 2,781 cases of malaria were registered as follows: dir xii-campinas (49.3%), dir xv-piracicaba (41.3%) and dir xx-são joão da boa vista (9.4%). the plasmodium vivax was found in 70.6% of the patients; plasmodium falciparum in 25.4% and 4% of the patients presented a mixed infection. the epidemiological classification showed that 95% of the cases came from the states of rondônia, mato grosso and par. the masculine sex, between the age of 20 to ... | 2000 | 10881119 |
| mutations in plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the amazon region of brazil. | since the late 1970s pyrimethamine-sulfadoxine (ps; fansidartm hoffman-laroche, basel) has been used as first line therapy for uncomplicated malaria in the amazon basin. unfortunately, resistance has developed over the last ten years in many regions of the amazon and ps is no longer recommended for use in brazil. in vitro resistance to pyrimethamine and cycloguanil (the active metabolite of proguanil) is caused by specific point mutations in plasmodium falciparum dihydrofolate reductase (dhfr), ... | 2000 | 10998224 |
| spatial analysis for stratification of priority malaria control areas, mato grosso state, brazil. | the goal of this study was to stratify priority areas for malaria control in the state of mato grosso, brazil, based on spatial analysis. the variables used were: annual parasite index (api), plasmodium falciparum/plasmodium vivax ratio, population variation, number of families settled, and percent of deforested area. the moran's i and local moran test were applied, visualized with the box map and moran map, for 1986- 1991, 1992-1997, and 1998-2003. box map identified areas with high, low, and i ... | 2007 | 17486233 |
| prevalence and level of antibodies to the circumsporozoite protein of human malaria parasites in five states of the amazon region of brazil. | the aim of this study was to determine the prevalence of malaria infection and antibodies against the repetitive epitopes of the circumsporozoite (cs) proteins of plasmodium falciparum, p. malariae, p. vivax vk210, p. vivax vk247, and p. vivax-like in individuals living in the states of rondônia, pará, mato grosso, amazonas, and acre. active malaria transmission was occurring in all studied sites, except in acre. p. falciparum was the predominant species in pará and rondônia and p. vivax in mato ... | 2007 | 17568943 |
| differential antibody responses to plasmodium falciparum invasion ligand proteins in individuals living in malaria-endemic areas in brazil and cameroon. | antibody responses to malaria invasion ligands and proteins on the merozoite surface have been shown to interfere with red cell invasion and correlate with immunity to malaria. the current study is the first to characterize the antibody responses to eba-140 and eba-181, plasmodium falciparum invasion ligands implicated in the alternative pathways of invasion, in age-matched populations of individuals living in endemic areas in both brazil and cameroon. antibody responses to the proteins screened ... | 2007 | 17984363 |
| evaluation of the genetic polymorphism of plasmodium falciparum p126 protein (sera or serp) and its influence on naturally acquired specific antibody responses in malaria-infected individuals living in the brazilian amazon. | the plasmodium falciparum p126 protein is an asexual blood-stage malaria vaccine candidate antigen. antibodies against p126 are able to inhibit parasite growth in vitro, and a major parasite-inhibitory epitope has been recently mapped to its 47 kda n-terminal extremity (octamer repeat domain--or domain). the or domain basically consists of six octamer units, but variation in the sequence and number of repeat units may appear in different alleles. the aim of the present study was to investigate t ... | 2008 | 18667071 |
| spatial patterns of malaria in a land reform colonization project, juruena municipality, mato grosso, brazil. | in brazil, 99% of malaria cases are concentrated in the amazon, and malaria's spatial distribution is commonly associated with socio-environmental conditions on a fine landscape scale. in this study, the spatial patterns of malaria and its determinants in a rural settlement of the brazilian agricultural reform programme called "vale do amanhecer" in the northern mato grosso state were analysed. | 2011 | 21703018 |
| antiplasmodial and cytotoxic activities of toad venoms from southern amazon, brazil. | the drug-resistance of malaria parasites is the main problem in the disease control. the huge brazilian biodiversity promotes the search for new compounds, where the animal kingdom is proving to be a promising source of bioactive compounds. the main objective of this study was to evaluate the antiplasmodial and cytotoxic activity of the compounds obtained from the toad venoms of brazilian amazon. toad venoms were collected from the secretion of rhinella marina and rhaebo guttatus in mato grosso ... | 2016 | 27658592 |