| [drug-resistant tropical malaria in angola]. | three antimalarial treatment regimens by the complete standard who tests were examined in 105 plasmodium falciparum-infected patients who were nonimmune newcomers treated at the russian hospital in luanda in 1991-1992, 61% showed chloroquine resistance and 40% fansidar resistance. all 59 patients with high rates of parasitemia were successfully cured with quinine in combination with tetracycline. thick, if required thin, blood smears were microscopically examined. the findings suggest that fansi ... | 1994 | 7935196 |
| infectious aetiology of jaundice among pregnant women in angola. | the contribution of viral hepatitis, human immunodeficiency virus (hiv) infection and malaria to jaundice among pregnant women in luanda, angola, was studied. 20 pregnant women with jaundice (cases) were identified in 2 large maternity hospitals and compared with 40 pregnant women without jaundice (controls). among the cases 6 patients died, whereas no death occurred in the control group (p < 0.001). five spontaneous abortions and 6 stillbirths were also noted among the cases, implying foetal lo ... | 2003 | 12953953 |
| assessment of clinical course and outcome of plasmodium falciparum malaria in angola diagnosed by microscopic and molecular methods. | malaria still remains the main infectious cause of morbidity and mortality in the world. the majority of cases occur in tropical africa, including angola. the study was performed in angola, in the health centre of st. lucas in kifangondo, near luanda during the dry season, from may to october 1999. 168 patients with symptoms of malaria were referred for study enrolment. in the study we assessed the efficacy of treatment in falciparum malaria based on clinical, microscopic and polymerase chain re ... | 2004 | 15881545 |
| malaria vectors in angola: distribution of species and molecular forms of the anopheles gambiae complex, their pyrethroid insecticide knockdown resistance (kdr) status and plasmodium falciparum sporozoite rates. | malaria is by far the greatest cause of morbidity and mortality in angola, being responsible for 50% of all outpatient attendance and around 22% of all hospital deaths, yet by 2003 only 2% of under-5s used insecticide-treated nets. entomological studies are an essential foundation for rational malaria control using insecticide-treated nets and indoor residual spraying, but there have been no published studies of malaria vectors in angola over the 27 years of the civil war, to its end in 2002. th ... | 2006 | 16420701 |
| detection of atovaquone-proguanil resistance conferring mutations in plasmodium falciparum cytochrome b gene in luanda, angola. | the fixed dose combination atovaquone-proguanil is a recently introduced antimalarial for treatment and prophylaxis of plasmodium falciparum malaria. it is highly effective with a good tolerability profile and a convenient prophylactic regimen. nevertheless, cases of treatment failure have already been reported, which have been associated to mutations in the cytochrome b gene of the plasmodium (pfcytb). the presence of atovaquone-proguanil in vivo resistance conferring mutations in pfcytb gene i ... | 2006 | 16597338 |
| prevalence of pfmdr1, pfcrt, pfdhfr and pfdhps mutations associated with drug resistance, in luanda, angola. | malaria is the infectious disease causing the highest morbidity and mortality in angola and due to widespread chloroquine (cq) resistance, the country has recently changed its first-line treatment recommendations for uncomplicated malaria, from cq to artemisinin combination therapies (act) in adults, and sulphadoxine/pyrimethamine (s/p) in pregnant women. loss of sp sensitivity is, however, progressing rapidly in africa and, in this study, were investigated a number of molecular markers associat ... | 2008 | 19014684 |
| plasmodium falciparum isolates from angola show the stctvmnt haplotype in the pfcrt gene. | effective treatment remains a mainstay of malaria control, but it is unfortunately strongly compromised by drug resistance, particularly in plasmodium falciparum, the most important human malaria parasite. although p. falciparum chemoresistance is well recognized all over the world, limited data are available on the distribution and prevalence of pfcrt and pfmdr1 haplotypes that mediate resistance to commonly used drugs and that show distinct geographic differences. | 2010 | 20565881 |
| prevalence and risk factors of plasmodium falciparum infections in pregnant women of luanda, angola. | pregnant women are at increased risk of malaria, but in angola, epidemiologic data from this group is almost inexistent. we conducted a cross-sectional study to determine the prevalence and risk factors of plasmodium falciparum infections in 567 pregnant angolan women living in luanda province. one in five women had p.-áfalciparum at delivery, diagnosed by pcr assay. age, residence and history of malaria during pregnancy were significantly associated with p.-áfalciparum infection, but gravidity ... | 2011 | 21729222 |
| molecular markers of antifolate resistance in plasmodium falciparum isolates from luanda, angola. | plasmodium falciparum malaria remains a leading health problem in africa and its control is seriously challenged by drug resistance. although resistance to the sulphadoxine-pyrimethamine (sp) is widespread, this combination remains an important component of malaria control programmes as intermittent preventive therapy (ipt) for pregnant women and children. in angola, resistance patterns have been poorly characterized, and ipt has been employed for pregnant women since 2006. the aim of this study ... | 2011 | 21864379 |
| evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and k13-propeller polymorphisms in luanda, angola. | drug resistance in plasmodium falciparum has posed an obstacle to effective treatment and challenges many malaria control programmes in endemic areas. in angola, until 2003, chloroquine (cq) was used as first-line therapy for uncomplicated malaria. it was replaced initially by amodiaquine and, in 2006, by artemisinin-based combination therapy (act) with artemether-lumefantrine (al, coartem(®)). efficacy study of act, conducted in angola between 2004 and 2005, showed a baseline efficacy of ≈99%. | 2015 | 26670642 |
| tuberculosis with malaria or hiv co-infection in a large hospital in luanda, angola. | three major public health problems, tuberculosis, malaria and hiv/aids, are widespread in angola, often as co-infections in the same individual. in 2009, it was assumed that 44,151 new cases of tb occurred in angola. interestingly, interventions such as treatment/prevention of malaria appear to reduce mortality in hiv-infected and possibly tb co-infected patients. however, despite the seriousness of the situation, current data on tb and co-infection rates are scarce. this study aimed to characte ... | 2013 | 23493006 |
| plasmodium falciparum infection in pregnant women attending antenatal care in luanda, angola. | malaria during pregnancy remains a serious public health problem. the aim of this study was to establish the prevalence and possible risk factors for malaria in pregnant women attending antenatal care at augusto ngangula specialized general hospital in luanda, angola. | 2012 | 22760138 |