| forty years of malaria eradication in sardinia. a new appraisal of a great enterprise. | the campaign against malaria in sardinia carried out by the ente regionale per la lotta anti-anofelica in sardegna (erlaas), appears today as one of the greatest efforts against malaria since the discovery of its aetiology and mode of transmission. the disease was eradicated without achieving the eradication of the vector, anopheles labranchiae, the main objective of the campaign. this species eradication failure had been at first attributed to the indigenous character of a. labranchiae and its ... | 1990 | 2132434 |
| genetic and population structure of four sardinian villages. | data on microgeographic population structure on four neighbouring villages of sardinia island (italy) are presented and discussed. two villages are located in the lowlands where malaria from plasmodium falciparum was endemic until the eradication of paludism. the other two villages are located in the highlands and they were malaria-free because of the altitude. census data, inbreeding, migration matrices and surname distributions have been collected. the genetic differentiation of the four villa ... | 1985 | 3865619 |
| status of malaria vectors in italy. | about 30 yr after malaria eradication, surveys to assess the presence and abundance of anopheline vectors were carried out in central and southern italy and in the islands of sardinia and sicily from 1992 to 1994. anopheles labranchiae falleroni was present in scattered foci in all regions, except for tuscany, where it breeds almost exclusively in rice fields (grosseto province). most common breeding sites were rivers and streams, followed by ponds and ground pools. the highest adult density was ... | 1997 | 9151488 |
| a 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-saharan to the mediterranean area: role of parasitic diseases and environmental conditions. | human chitotriosidase (chit) is a member of the chitinase family and it is synthesized by activated macrophages. recently, a genetic polymorphism was found to be responsible for the common deficiency in chit activity, frequently encountered in different populations. we analyzed the chit gene in some ethnic groups from the mediterranean and african areas, to evaluate whether the chit gene polymorphism correlates with the changes in environmental features and the disappearance of parasitic disease ... | 2003 | 14647197 |
| tnfa locus is associated with beta degrees 39 thalassemia in corsica and sardinia. | malaria causes more than one million deaths annually, worldwide. understanding the genetic defenses against this disease is an important challenge for science. we know that the long-term presence of endemic malaria has led to a prevalence of the beta degrees 39 heterozygous thalassemia mutation in the two islands of corsica and sardinia. the populations of both islands are isolated, which could make it easier to find other genetic traits selected by disease pressure. we chose to investigate gene ... | 2008 | 19103526 |
| evidence for malaria selection of a cr1 haplotype in sardinia. | complement receptor 1 (cr1) levels have been associated with malarial susceptibility and/or severity of the disease in different population groups, and cr1 is a receptor for plasmodium falciparum. in this study, multiple cr1 single-nucleotide polymorphisms (snps) showed strong evidence of population differentiation between sardinian and other european ethnic groups. cross population algorithms comparing haplotype structure and differences in haplotype and allele frequency distribution provided a ... | 2011 | 21593778 |
| anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the mediterranean area. | sardinia is a mediterranean area endemic for malaria up to the last century. during a screening study to evaluate the anti-plasmodial activity of some aromatic plants traditionally used in sardinia, myrtus communis (myrtle, myrtaceae), satureja thymbra (savory, lamiaceae), and thymus herba-barona (caraway thyme, lamiaceae) were collected in three vegetative periods: before, during and after flowering. | 2012 | 22747579 |