| relationships between circulating s-antigens, naturally acquired antibodies to plasmodium falciparum exoantigens and malaria attack in a mesoendemic area. | a survey involving 77 individuals living in two savannah villages near bobo dioulasso (burkina faso, west africa), was performed in june 1987 (before), august-september (during) and january 1988 after the seasonal transmission. the clinical longitudinal study during the seasonal period permitted us to define three different groups in terms of both age and occurrence of malaria attack (ma; greater than or equal to 5000 parasites/mm3 of blood and axillary fever greater than or equal to 37.8 degree ... | 1992 | 1356300 |
| [variation of the parasite density of plasmodium falciparum in asymptomatic carriers: consequences for malaria chemoresistance studies]. | during the studies on malaria chemoresistance, we noted great variations in parasite density of plasmodium falciparum between screening in the morning and final selection in the afternoon, in asymptomatic people. to better understand this phenomenon, we conducted a study in october 1987 on primary school children in a village near the city of bobo-dioulasso, at the peak malaria prevalence. we performed 3 blood-smears at 8 a.m., 2 p.m. and 8 p.m., on day 0 and day 4, to an initial number of 86 ch ... | 1992 | 1435194 |
| [vaccination against malaria: initial trial with an ant-sporozoite vaccine, (nanp)3-tt (ro 40-2361) in africa (bobo-dioulasso, burkina faso)]. | the vaccine (nanp)3-tt is a synthetic peptide of the circumsporozoite protein (cs) of plasmodium falciparum coupled to tetanus toxoid (tt) as protein carrier and adsorbed to aluminium hydroxide as adjuvant. the objectives of the study were to assess the immunogenicity and the protective efficacy of the vaccine in an area where malaria is endemic. the study was conducted in a zone of irrigated rice cultivation known as the vallée du kou to the north of bobo-dioulasso. malaria transmission is perm ... | 1990 | 2119897 |
| [production of sporozoites of human plasmodium in bobo-dioulasso (burkina faso)]. | mass production of p. falciparum sporozoites requires an intensive production of mosquitoes and an experimental infection of this vector. a gambiae is the main vector of p. falciparum, and p. ovale in burkina. in the first part we study 3 factors interfering with breeding and experimental infection of this anopheline species. they are: insectarium temperature, pattern and rhythm of blood feeding. in the second part, we study "parasite", "host" and "mosquito" parameters which interfere with the y ... | 1989 | 2658878 |
| [iterative placental infection by p. falciparum during 2 successive pregnancies in bobo-dioulasso (burkina-faso)]. | a young woman living in a malaria endemic area in west africa, was contaminated twice with placental infection by plasmodium falciparum, in two successive pregnancies. no parasites were observed on blood smears both in mother peripheral blood and in cord blood. a parasitemia was described in the intervillous space in the placental. the first placental infection was attributed to a febrile illness ten days before the end of gestation. no reliable symptoms of malaria were found for the second infe ... | 1989 | 2670290 |
| [malaria in employees of an african industrial enterprise (bobo dioulasso, burkina faso)]. | | 1988 | 3069058 |
| [malaria morbidity in a hospital environment in burkina faso (west africa)]. | we carried out a study on malaria morbidity from november 1982 to october 1983 in the pediatric department of the hospital of bobo dioulasso (burkina faso, west africa). malaria fever attacks were present in 21.4% of all febrile cases. the highest rate was observed in the 2-4 age group (42%). we observed 97.4% of all malaria fever attacks during the rainy season and the beginning of the dry season (june to december). | 1988 | 3285119 |
| [longitudinal study of malaria indices in 2 villages of the bobo dioulasso region (burkina faso)]. | | 1985 | 3907536 |
| [the treatment of plasmodium falciparum malaria in the region of bobo-dioulasso, upper volta]. | | 1973 | 4597412 |
| [comparative study of a single dose of the pyrimethamine-sulfametopyrazine combination and chloroquine in the treatment of malaria attacks caused by plasmodium falciparum in semi-immune patients in endemic areas (study carried out in bobo-dioulasso, upper volta)]. | | 1972 | 4675015 |
| ten-year surveillance of drug-resistant malaria in burkina faso (1982-1991). | to understand the evolution of drug-resistant forms of malaria in time and in space, we carried out an analysis of the results of a series of passive and active surveys conducted in burkina faso between 1982 and 1991. a total of 607 tests for resistance to chloroquine and mefloquine were carried out in vitro and 3,679 tests for resistance to chloroquine, quinine, and sulfadoxine-pyrimethamine were performed in vivo. the surveys principally involved the two main cities of burkina faso, ouagadougo ... | 1994 | 8024062 |
| [malaria following surgery in an endemic region]. | the frequency of malaria attacks after surgery was determined during a 3-month period in the surgical ward of bobo-dioulasso hospital (burkina faso). the survey was carried out during the period of highest malarial morbidity. all adolescents and adults admitted to the ward were included, except women undergoing cesarian section and patients who died in the perisurgical period. patients were questioned as to the use of antimalarial drugs during the days prior to admission, their occupation and th ... | 1994 | 8186922 |
| selected p. falciparum specific immune responses are maintained in aids adults in burkina faso. | in tropical areas where plasmodium falciparum malaria is endemic, co-infection with hiv-1 does not lead to a worsening of malaria, raising questions about the immunological interactions between both infections. alterations of immune response to malaria during hiv-1 infection was investigated in the town of bobo dioulasso, burkina faso. sixty-six adults were enrolled, including 37 hiv-1 positive subjects with < 250 cd4+ cells/microliter and clinical aids, and 29 hiv-1, negative healthy subjects. ... | 1996 | 9229386 |
| in vitro sensitivity of plasmodium falciparum to halofantrine compared with chloroquine, quinine and mefloquine in the region of bobo-dioulasso, burkina faso (west africa). | the in vitro sensitivity of p. falciparum drug-resistant isolates was evaluated in the region of bobo-dioulasso during the 1995 and 1996 rainy seasons. two routinely used antimalarials (chloroquine and quinine) and two new antimalarials (mefloquine and halofantrine) were assessed using 24-hour in vitro cultures with tritiated hypoxanthine and a parasite density > or = 4,000/microl of blood. the proportion of chloroquine-resistant isolates was 20% in 1995 and 19% in 1996, whilst in 1996, the prop ... | 1998 | 9623943 |
| [analysis of the genetic factors controlling malarial infection in man]. | genetic factors have clearly been shown to play a role in controlling malarial infection in animal models. there is now also increasing evidence for the genetic control of malaria in man. we carried out a segregation analysis based on blood parasite load phenotype for a population of the town of bobo-dioulasso (burkina-faso). this analysis demonstrated a strong genetic effect. our results were not consistent with the segregation of a major gene and thus suggest that parasite load is under the co ... | 1999 | 10210803 |
| chloroquine and sulphadoxine-pyrimethamine efficacy for uncomplicated malaria treatment and haematological recovery in children in bobo-dioulasso, burkina faso during a 3-year period 1998-2000. | we determined the parasitological resistance and the clinical failure to chloroquine (cq) and sulphadoxine-pyrimethamine (sp) by the who 14-day in vivo test over three consecutive years in 948 children aged 6-59 months with uncomplicated malaria attending four health centres in the province of houet, burkina faso. children were alternatively allocated to either cq or sp. packed cell volume (pcv) was measured at days 0 and 14. parasitological resistance (ri, rii and riii) to cq was 18% (83 of 455 ... | 2002 | 12390597 |
| [in vitro susceptibility of 232 isolates of plasmodium falciparum to antimalarials in burkina faso (west africa)]. | plasmodium falciparum in vitro susceptibility to chloroquine, quinine, mefloquine and halofantrine was investigated in patients living in bobo-dioulasso (burkina faso, west africa). our study was carried out from july to november 1997 at the malaria chemoresistance reference centre, centre murazioccge. inclusion criteria were: presence of a single infection by r falciparum with a parasite count > or =4000 infected red cells/mm3. the susceptibility to drugs was measured after an incubation period ... | 2001 | 16579075 |
| roles of specific plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in burkina faso. | we evaluated associations between key polymorphisms in target genes and responses to treatment with sulfadoxine-pyrimethamine (sp) or amodiaquine (aq) for uncomplicated plasmodium falciparum malaria in bobo-dioulasso, burkina faso. presence of the dihydrofolate reductase (dhfr) 108n or 59r mutations (but not dhfr 51i or dihydropteroate synthetase [dhps] 437g) and p. falciparum chloroquine resistance transporter (pfcrt) 76t or p. falciparum multidrug resistance 1 (pfmdr1) 86y or 1246y mutations ( ... | 2006 | 16837725 |
| [in vivo sensitivity of plasmodium faciparum to chloroquine and sulfadoxine pyrimethamine in the bobo dioulasso region (1998-2001): risk factors associated with treatments failures to the two drugs]. | the therapeutic efficacy of chloroquine (cq) and sulfadoxine-pyrimethamine (sp) was determined over a 4 year period (1998-2001) in bobo dioulasso, burkina faso, with an analysis of the risk factors associated to treatment failures to the 2 drugs. in total, 2008 children (6 months-15 years old) attending in 4 health centres (1 urban and 3 rural) were included in the study. children were alternatively allocated to either cq or sp the who 14-days in vivo field test was carried out. pcv was measured ... | 2006 | 16983817 |
| randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated plasmodium falciparum malaria in burkina faso. | combination antimalarial therapy is advocated to improve treatment efficacy and limit selection of drug-resistant parasites. we compared the efficacies of 3 combination regimens in bobo-dioulasso, burkina faso: amodiaquine plus sulfadoxine-pyrimethamine, which was recently shown to be highly efficacious at this site; artemether-lumefantrine, the new national first-line antimalarial regimen; and dihydroartemisinin-piperaquine (dp), a newer regimen. | 2007 | 17990228 |