| rapid detection of pfcrt and pfmdr1 mutations in plasmodium falciparum isolates by fret and in vivo response to chloroquine among children from osogbo, nigeria. | chloroquine (cq) has been in use in africa for a long time. because of misuse, this drug has now lost its efficacy due to the emergence of resistance strains in most parts of africa. recently, it was shown that after chloroquine has been withdrawn from the market, chloroquine-sensitive plasmodium falciparum re-emerged and chloroquine could again be used successfully as an antimalarial. surveillance of parasite populations is, therefore, important to decide whether chloroquine could be re-introdu ... | 2007 | 17428334 |
| chloroquine resistant plasmodium falciparum malaria in osogbo nigeria: efficacy of amodiaquine + sulfadoxine-pyrimethamine and chloroquine + chlorpheniramine for treatment. | chloroquine (cq) resistance in plasmodium falciparum contributes to increasing malaria-attributable morbidity and mortality in sub-saharan africa. despite a change in drug policy, continued prescription of cq did not abate. therefore the therapeutic efficacy of cq in uncomplicated falciparum malaria patients was assessed in a standard 28-day protocol in 116 children aged between six and 120 months in osogbo, southwest nigeria. parasitological and clinical assessments of response to treatment sho ... | 2008 | 18368238 |
| prevalence and transmission pattern of plasmodium falciparum infection in osogbo metropolis, southwest, nigeria. | plasmodium falciparum malaria is an endemic disease especially in tropical areas with heavy rainfall that spread round the year. we therefore sought to investigate the prevalence pattern and clinical presentation of falciparum malaria in oso degrees c were assessed and screened for plasmodium falciparum infection by clinical assessment and microscopy using both thick and thin blood smears over a period of 12 months- august 2004 and july 2005. the prevalence of plasmodium falciparum infection was ... | 2007 | 18564645 |
| molecular surveillance of drug-resistant plasmodium falciparum in two distinct geographical areas of nigeria. | drug resistance against p. falciparum has been recognized as the crucial obstacle to curbing mortality and morbidity from malaria. we therefore determined the baseline distribution of pfcrt and pfmdr1 genes associated with resistance to chloroquine and pfdhfr gene associated with resistance to pyrimethamine in p. falciparum isolates collected from two geographically distinct areas of nigeria. we use rt-pcr assays and sequencing to determine the prevalence of these mutations. the combined prevale ... | 2010 | 21120702 |
| allelic diversity of merozoite surface protein 2 gene of p falciparum among children in osogbo, nigeria. | the genetic diversity of plasmodium falciparum (p falciparum) infections in humans is implicated in the pathogenesis of malaria. this study provides the first estimate of the genetic diversity and genotype multiplicity of plasmodium falciparum infection in children with uncomplicated p falciparum malaria in osogbo, nigeria. one hundred and one isolates were used for analysis of parasite population polymorphism and genotyped by nested-pcr of merozoite surface protein 2 (msp2) block 3. amplicons w ... | 2011 | 21809706 |
| plasma cytokines, chemokines and cellular immune responses in pre-school nigerian children infected with plasmodium falciparum. | malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. this study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school nigerian children infected with plasmodium falciparum from four semi-urban villages near ile-ife, osun state, nigeria. | 2013 | 23294670 |