| correlation between in vivo and in vitro response of chloroquine-resistant plasmodium falciparum in calabar, south-eastern nigeria. | since chloroquine-resistant plasmodium falciparum (crpf) has emerged in nigeria, we monitored the susceptibility of the parasite strain to a standard chloroquine (c25) dose in our children's emergency unit. chloroquine (cq) is the drug of choice for malaria chemotherapy in nigeria. the who 7-day in vivo evaluation and rieckmann's microtitre technique (in vitro test) were used. 33 children of mean age 4.9 years were enrolled in the study. 27 (81.8%) of the in vitro cultures were successful. 16 (5 ... | 1991 | 1680278 |
| problems of chloroquine-resistant p. falciparum in nigeria: one antimalaria drugs' utilisation in metropolitan calabar. | we studied the antimalarial drugs utilisation pattern in urban calabar, with a view to determining what drugs people take when they have malaria attack and who diagnoses and prescribes the drugs. we used a standard questionnaire data sheet to record the results of the interview carried out by the authors. malaria symptoms and the drugs consumed were diagnosed and prescribed respectively by self (54pc), qualified medical doctor (32pc) and others including paramedical staff (2pc). the rest (12pc) ... | 1991 | 2060003 |
| sensitivity of plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine in nigerian children. | the in vivo sensitivity of plasmodium falciparum to chloroquine and sulfadoxine/pyrimethamine was evaluated in children under 5 years of age in two areas of southern nigeria in 1987. a modification of the who standard field and extended tests (in vivo) was used, with follow-up on days, 2, 3, 7, and 14 after treatment with 25 mg chloroquine per kg body weight given over 3 days, or with standard doses of sulfadoxine/pyrimethamine. clinical and parasitological evaluations were performed. at igbo or ... | 1990 | 2189585 |
| haemoparasites of blood donors in calabar. | the study of haemoparasites in our blood donors revealed the following parasite prevalences: microfilaria (mf) of loa loa (1.3%); dipetalonema perstans (15.6%); loa loa and d. perstans (0.2%), plasmodium falciparum (3.3%), plasmodium malariae (1.0%) and a mixture of p. falciparum and p. malariae (0.2%). no trypanosomes were observed in the 480 blood samples screened. there were more cases of d. perstans infection in the 24-30 year age group, indicating their increased exposure frequencies. match ... | 1989 | 2763348 |
| htlv-i antibodies in blood donors, patients with leukaemia, acute malaria and multiple blood transfusion recipients in the cross river state of nigeria. | | 1988 | 3071466 |
| antibodies to human immunodeficiency virus (htlv-iii/lav) in people from lagos and cross river states of nigeria. | using enzyme-linked immunosorbent assay (elisa) and confirmatory immunoprecipitation tests, sera from 640 nigerians from lagos and cross river states were examined for antibodies against hiv. these comprised 570 blood donors and their family members, 56 patients with various haematological conditions and 14 patients with acute plasmodium falciparum infection. none of the sera was positive for htlv-iii/lav antibodies by immunoprecipitation, although 12 (1.9%) sera were positive by elisa. | 1988 | 3124480 |
| congenital malaria at university of calabar teaching hospital with reference to haemoglobin and immunoglobulin. | | 1985 | 3914920 |
| upsurge of malaria-related convulsions in a paediatric emergency room in nigeria. consequence of emergence of chloroquine-resistant plasmodium falciparum. | from january through december 1988 the causative factor of each case of childhood seizure seen in the children's emergency room of the university of calabar teaching hospital, calabar, nigeria, was prospectively studied with a focus on the relative importance of malaria-related seizures. of the 134 seizure cases seen, febrile convulsion (fc) formed the majority (55%) with cerebral malaria (cm) as the only major (33%) rival. other conditions such as meningitis, epilepsy, hypoglycaemia and drug po ... | 1993 | 8362450 |
| in vivo efficacy of chloroquine, halofantrine, pyrimethamine-sulfadoxine and qinghaosu (artesunate) in the treatment of malaria in calabar, nigeria. | we used the who in vivo seven day test, extended to 14 day follow up to evaluate the efficacy of the alternative antimalarial drugs in nigeria (1992), where chloroquine resistant p. falciparum (crpd) has been confirmed. one thousand and four patients were screened. those fulfilling recruitment criteria were randomly treated with chloroquine (cq), n = 50, halofantrine (h), n = 53, pyrimethamine-sulfadoxine (p-s), n = 52 and qinghaosu (q), n = 53. parasitological treatment failures were found with ... | 1996 | 8791866 |
| chloroquine-resistant plasmodium falciparum among children in calabar, south eastern nigeria. | sixty-nine children aged between 6 and 60 months with parasitologically proven plasmodium falciparum malaria were treated with chloroquine (2.5 mg/kg) in the children's emergency room of the university of calabar teaching hospital (ucth) in 1993. thirty subjects (mean age 27.8 months) and 39 (mean age 29.5 months) received chloroquine phosphate suppository (pharma deko) and chloroquine sulphate syrup (may & baker), respectively. the world health organization (who) 14-day in vivo field test was u ... | 1997 | 9227007 |
| efficacy and tolerability of a low-dose mefloquine-sulfadoxine-pyrimethamine combination compared with chloroquine in the treatment of acute malaria infection in a population with multiple drug-resistant plasmodium falciparum. | the efficacy and tolerability of single, low-dose mefloquine, sulfadoxine-pyrimethamine (msp) combination was compared with chloroquine (cq) for malaria treatment in a malaria-endemic area of nigeria with multiple drug-resistant plasmodium falciparum. the two drug regimens (msp and cq) were tested in a 12-month prospective population study. the patients were divided into two groups. group 1 patients were treated presumptively, based on malaria symptoms. group 2 patients were treated based on a p ... | 1999 | 10432067 |
| artemether-lumefantrine versus artesunate plus amodiaquine for treating uncomplicated childhood malaria in nigeria: randomized controlled trial. | the therapeutic efficacy of artesunate plus amodiaquine and artemether/lumefantrine were assessed in an area of nigeria with high levels of plasmodium falciparum resistance to chloroquine and sulphadoxine-pyrimethamine. | 2006 | 16704735 |
| antimalarial drug prescribing practice in private and public health facilities in south-east nigeria: a descriptive study. | nigeria's national standard has recently moved to artemisinin combination treatments for malaria. as clinicians in the private sector are responsible for attending a large proportion of the population ill with malaria, this study compared prescribing in the private and public sector in one state in nigeria prior to promoting acts. | 2007 | 17480216 |
| the prevalence of congenital malaria among neonates with suspected sepsis in calabar, nigeria. | we studied the prevalence of congenital malaria among neonates with suspected sepsis and its outcome at the university of calabar teaching hospital, calabar, nigeria. all in-born neonates admitted to the newborn unit with clinical features suggestive of sepsis were recruited. they were screened for bacterial sepsis and malaria. the mothers of the neonates that had parasitaemia were further screened for malaria and anaemia. a total of 546 in-born neonates were admitted to the neonatal unit and 20 ... | 2008 | 18453488 |