| splenic lymphoma with villous lymphocytes should be included in the differential diagnosis of massive splenomegaly. | to distinguish between patients with reactive lymphocytosis and those with malignant lymphoid proliferations, with particular reference to hyper-reactive malarial splenomegaly and splenic lymphoma with villous lymphocytes. | 1998 | 9841942 |
| malariometric update for the rainforest and savanna of ashanti region, ghana. | the epidemiological features of human infection with plasmodium were studied in a community-based survey of 35 villages in the ashanti region of ghana. the overall prevalences of malarial parasitaemia in subjects aged > or = 2 years were 50.72% in forest areas and 49.72% in savanna. plasmodium falciparum was the predominant species everywhere, followed by p. malariae in the savanna and p. ovale in the forest. the highest prevalence of asexual parasitaemia (of any species) occurred in the younges ... | 2000 | 10723520 |
| ctla-4 positive t cells in contrast to procalcitonin plasma levels discriminate between severe and uncomplicated plasmodium falciparum malaria in ghanaian children. | procalcitonin (pct) plasma levels and the fraction of ctla-4-positive t cells are both elevated in acute plasmodium falciparum malaria in human adults and the degree of elevation is positively correlated with other markers of disease severity, for example with parasitaemia. however, the clinical manifestations of malaria are strongly age-dependent and children from endemic areas carry the main disease burden. therefore, we measured pct plasma levels and ctla-4 expression by t cells in four group ... | 2003 | 14629769 |
| malaria and anaemia among children in two communities of kumasi, ghana: a cross-sectional survey. | a survey in kumasi, ghana found a marked plasmodium falciparum prevalence difference between two neighbouring communities (moshie zongo and manhyia). the primary objective of this follow-up study was to determine whether this parasite rate difference was consistent over time. secondary objectives were to compare prevalences of clinical malaria, anaemia, intestinal parasite infections, and malnutrition between these communities; and to identify potential risk factors for p. falciparum infection a ... | 2006 | 17094806 |
| a randomized trial on effectiveness of artemether-lumefantrine versus artesunate plus amodiaquine for unsupervised treatment of uncomplicated plasmodium falciparum malaria in ghanaian children. | numerous trials have demonstrated high efficacy and safety of artemisinin-based combination therapy (act) under supervised treatment. in contrast, effectiveness studies comparing different types of act applied unsupervised are scarce. the aim of this study was to compare effectiveness, tolerability and acceptance of artesunate plus amodiaquine (asaq) against that of artemether-lumefantrine (al) in ghanaian children with uncomplicated plasmodium falciparum malaria. | 2008 | 19099594 |
| the lambaréné organ dysfunction score (lods) is a simple clinical predictor of fatal malaria in african children. | plasmodium falciparum malaria accounts for >1 million deaths annually, mostly among young children in sub-saharan africa. identifying those individuals who are likely to die is crucial. several factors have been independently associated with death. because malaria is a systemic disease, a quantitative score combining such risk factors may be superior. | 2009 | 19911989 |
| the effect of malaria and intestinal helminth coinfection on birth outcomes in kumasi, ghana. | this study was conducted to investigate the effect of plasmodium falciparum and intestinal helminth coinfection on maternal anemia and birth outcomes. a cross-sectional study of 746 women who delivered in two hospitals in kumasi was conducted. data were collected using an investigator-administered questionnaire and from patients' medical records. blood was collected for determination of p. falciparum and hemoglobin levels. adverse pregnancy outcomes were high (44.6%). coinfection (versus no infe ... | 2010 | 20064991 |
| exploring the relationship between chronic undernutrition and asymptomatic malaria in ghanaian children. | a moderate association has been found between asymptomatic parasitaemia and undernutrition. however, additional investigation using the gold standard for asymptomatic parasitaemia confirmation, polymerase chain reaction (pcr), is needed to validate this association. anthropometric measurements and blood samples from children less than five years of age in a rural ghanaian community were used to determine if an association exists between chronic undernutrition and pcr-confirmed cases of asymptoma ... | 2010 | 20122258 |
| differing effects of hbs and hbc traits on uncomplicated falciparum malaria, anemia, and child growth. | the high prevalence of hemoglobin s (hbs) in africa and hemoglobin c (hbc) in parts of west africa is caused by the strong protection against severe falciparum malaria during childhood. much less is known about the effect of hbs and especially hbc on plasmodium falciparum infection, uncomplicated malaria, and anemia. a total of 1070 children from the ashanti region, ghana, were enrolled at the age of 3 months and visited monthly until 2 years of age. the effects of the beta-globin genotype on th ... | 2010 | 20231425 |
| malaria transmission in two rural communities in the forest zone of ghana. | malaria transmission was assessed in two rural communities, kona and afamanaso in sekyere south district, ashanti region, in the forest zone of ghana to provide baseline data for ongoing clinical studies and the evaluation of the effect of interventions. altogether, 3,479 anopheles gambiae and 1,157 anopheles funestus were caught by human landing catches. sporozoite rates determined by either microscopy of salivary glands or enzyme-linked immunosorbent assay (elisa) for plasmodium falciparum in ... | 2010 | 21153839 |
| geographically weighted regression of land cover determinants of plasmodium falciparum transmission in the ashanti region of ghana. | malaria is a mosquito-borne parasitic disease that causes severe mortality and morbidity, particularly in sub-saharan africa. as the vectors predominantly bite between dusk and dawn, risk of infection is determined by the abundance of p. falciparum infected mosquitoes in the surroundings of the households. remote sensing is commonly employed to detect associations between land use/land cover (lulc) and mosquito-borne diseases. due to challenges in lulc identification and the fact that lulc merel ... | 2014 | 25270342 |
| rickettsia felis infection in febrile children, ghana. | rickettsial infections are an underrecognized cause of febrile illness in sub-saharan africa. to evaluate the epidemiology and clinical features of rickettsial disease in pediatric patients in ghana, we screened blood samples from febrile children aged less than 15 years presenting to an outpatient department in ghana's ashanti region for the presence of rickettsial dna. we detected rickettsia felis in 7/470 (1.5%) blood samples, using two independent real-time polymerase chain reactions. no oth ... | 2017 | 28115672 |
| lack of association of cd55 receptor genetic variants and severe malaria in ghanaian children. | in a recent report, the cellular receptor cd55 was identified as a molecule essential for the invasion of human erythrocytes by plasmodium falciparum, the causal agent of the most severe form of malaria. as this invasion process represents a critical step during infection with the parasite, it was hypothesized that genetic variants in the gene could affect severe malaria (sm) susceptibility. we performed high-resolution variant discovery of rare and common genetic variants in the human cd55 gene ... | 2017 | 28104671 |