| molecular markers of anti-malarial drug resistance in central, west and east african children with severe malaria. | the plasmodium falciparum multidrug resistance 1 (pfmdr1), p. falciparum ca(2+)-atpase (pfatp6) and kelch-13 propeller domain (pfk13) loci are molecular markers of parasite susceptibility to anti-malarial drugs. their frequency distributions were determined in the isolates collected from children with severe malaria originating from three african countries. | 2017 | 28535801 |
| dynamics in multiplicity of plasmodium falciparum infection among children with asymptomatic malaria in central ghana. | the determinants of malaria parasite virulence is not entirely known, but the outcome of malaria infection (asymptomatic or symptomatic) has been associated with carriage of distinct parasite genotypes. alleles considered important for erythrocyte invasion and selected as candidate targets for malaria vaccine development are increasingly being shown to have distinct characteristics in infection outcomes. any unique/distinct patterns or alleles linked to infection outcome should be reproducible f ... | 2017 | 28716086 |
| natural antibody responses to plasmodium falciparum msp3 and glurp(r0) antigens are associated with low parasite densities in malaria patients living in the central region of ghana. | plasmodium falciparum genetic diversity and multiplicity of infection (moi) are parasite features that have been suggested to influence the acquisition of protective immunity against malaria. this study sought to assess the relationship between moi and parasite density (pd) in malaria patients living in the central region of ghana and to determine whether naturally occurring antibody levels against p. falciparum glurp (pf3d7_1035300) and msp3 (pf3d7_1035400) antigens are associated with decrease ... | 2017 | 28835262 |
| estimating malaria parasite density: assumed white blood cell count of 10,000/μl of blood is appropriate measure in central ghana. | white blood cells count (wbcc) is a bedrock in the estimation of malaria parasite density in malaria field trials, interventions and patient management. white blood cells are indirectly and relatively used in microscopy to estimate the density of malaria parasite infections. due to frequent lack of facilities in some malaria-endemic countries, in order to quantify wbcc of patients, an assumed wbcc of 8.0 x 10(9)/l has been set by the world health organization to help in estimating malaria parasi ... | 2012 | 22823983 |
| use of proscribed chloroquine is associated with an increased risk of pfcrt t76 mutation in some parts of ghana. | after years of disuse of chloroquine (cq) as first-line anti-malarial drug in ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of t76 mutation in the pfcrt gene. this situation has several health implications, one being that mutations that confer resistance to cq have been reported to show substantial cross-resistance to other anti-malarial drugs. it is important to identify some of the factors contributing to the continuous presence of cq resis ... | 2014 | 24969960 |
| epidemiology of malaria in the forest-savanna transitional zone of ghana. | information on the epidemiology of malaria is essential for designing and interpreting results of clinical trials of drugs, vaccines and other interventions. as a background to the establishment of a site for anti-malarial drugs and vaccine trials, the epidemiology of malaria in a rural site in central ghana was investigated. | 2009 | 19785766 |
| relationship of hepcidin with parasitemia and anemia among patients with uncomplicated plasmodium falciparum malaria in ghana. | the pathogenesis of malarial anemia is incompletely understood. hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation. the specific aim of the study was to characterize the association between urinary hepcidin, hemoglobin, and parasitemia in 199 patients presenting for evaluation of plasmodium falciparum malaria in ghana. urinary hepcidin was semi-quantitatively assessed using surface-e ... | 2007 | 17978060 |
| population pharmacokinetics of intramuscular quinine in children with severe malaria. | we present the first population pharmacokinetic analysis of quinine in patients with plasmodium falciparum malaria. ghanaian children (n = 120; aged 12 months to 10 years) with severe malaria received an intramuscular loading dose of quinine dihydrochloride (20 mg/kg of body weight). a two-compartment model with first-order absorption and elimination gave post hoc estimates for pharmacokinetic parameters that were consistent with those derived from non-population pharmacokinetic studies (clearan ... | 2001 | 11353629 |
| seasonal characteristics of malaria infection in under-five children of a rural community in southern ghana. | in a quarterly survey of malaria infection in the under-five children conducted at gomoa onyadze/otsew jukwa, a rural community in the central region of ghana from december, 1986 to september, 1987, crude parasite rates ranged from 19.6 to 33.5 per cent in the dry season (december and march) and 33.0 to 44.0 per cent in the wet season (june and september). p. falciparum was the predominant parasite species by parasite formula analysis with higher rates in the rainy season (94.2 to 95.8 per cent) ... | 1993 | 8512880 |