| a new look at the protection of hemoglobin as and ac genotypes against plasmodium falciparum infection: a census tract approach. | a total of 4,097 randomly selected children under 5 years in accra, ghana were investigated for hb type, malarial parasite species, and parasite density. even though malarial infection rates in this metropolitan population were lower as compared to holoendemic areas, the differential survival of hb s carriers was confirmed. in addition, similar but less pronounced survival effects were seen in hb c heterozygotes. hb s carriers had the highest infection rates. more females than males were infecte ... | 1976 | 773175 |
| plasmodium falciparum: susceptibility in vitro and in vivo to chloroquine and sulfadoxine-pyrimethamine in ghanaian schoolchildren. | in ghana, resistance of plasmodium falciparum to chloroquine was observed for the first time in 1986. by the end of 1991 it had reached a high frequency and a substantial degree. a combined study in vivo and in vitro of the response of p. falciparum to chloroquine and sulfadoxine/pyrimethamine was carried out in madina, accra, in the coastal area of ghana, late in 1991. 96 valid tests in vivo were performed with children and adolescents. there were 52 successful tests in vitro with chloroquine, ... | 1994 | 7570837 |
| selective activation of tcr-gammadelta+ cells in endemic burkitt's lymphoma. | the overlap in geographical distribution of plasmodium falciparum malaria and endemic burkitt's lymphoma (ebl)--an aggressive epstein-barr virus (ebv)-associated b-cell tumour occurring almost exclusively in the tropics--strongly suggests a link between the two diseases. it is suspected that the polyclonal b-cell activation in p. falciparum malaria may precipitate a breakdown in homeostatic t-cell control of ebv-immortalized b-cell proliferation. previous studies have suggested that a particular ... | 2007 | 17521425 |
| retinopathy in severe malaria in ghanaian children--overlap between fundus changes in cerebral and non-cerebral malaria. | in malaria-endemic areas, reliably establishing parasitaemia for diagnosis of malaria can be difficult. a retinopathy with some features unique to severe malaria with a predictive value on prognosis, has been described. detection of this retinopathy could be a useful diagnostic tool. this study was designed to determine the diagnostic usefulness of retinopathy on ophthalmoscopy in severe malaria syndromes: cerebral malaria (cm) and non-cerebral severe malaria (non-cm), i.e. malaria with respirat ... | 2010 | 20704742 |
| notes from the field: malaria imported from west africa by flight crews --- florida and pennsylvania, 2010. | on september 15, 2010, cdc notified the florida and pennsylvania departments of health of four plasmodium falciparum--associated malaria cases among employees of a single commercial airline. all four employees had traveled to accra, ghana, during august 25-september 2, 2010, two of whom were on the same flight. their duration of stay in accra ranged from 48 to 80 hours. all had stayed at the same hotel and spent time outdoors near the swimming pool, in restaurants without air conditioning, and i ... | 2010 | 21077407 |
| antibodies reactive to plasmodium falciparum serine repeat antigen in children with burkitt lymphoma from ghana. | the role of protective immunity to plasmodium falciparum (pf) malaria in burkitt lymphoma (bl) is unknown. we investigated the association between bl and antibodies reactive to se36 antigen, a recombinant protein based on pf-sera5 gene, targeted by protective malaria immune responses. cases were children (0-14 years) enrolled at the korle-bu teaching hospital, accra, ghana, during 1965-1994 with bl confirmed by histology or cytology (92% of cases). controls were healthy appearing children enroll ... | 2011 | 21630256 |
| burden of malaria in mobile populations in the greater accra region, ghana: a cross- sectional study. | the burden of malaria in mobile populations remains poorly documented in sub-saharan africa. this study determined the prevalence of malaria among hawkers and long-distance truck drivers in the greater accra region of ghana. | 2017 | 28274262 |