| unexpected trend in chemosensitivity of plasmodium falciparum in brazzaville, congo. | | 1991 | 1678846 |
| [comparative efficacy of chloroquine and amodiaquine (25 and 35 mg/kg) in school children infected with p. falciparum (brazzaville, march 1990)]. | the efficacy of 4 therapeutic schedules was compared in march and april 1990 in brazzaville school children, aged between 6 and 8 years, with parasitaemia of at least 1,000 trophozoites of plasmodium falciparum per mm3. it was possible to interpret 125 simplified in vivo tests. the results showed that the activity of amodiaquine is still relatively satisfactory. the activity of chloroquine was slightly lower with the schedule of 25 mg/kg but was good at 35 mg/kg. although these results were obta ... | 1991 | 2065405 |
| [surveillance of the in vivo sensitivity of plasmodium falciparum to antimalarial agents: the results of initial tests of the oceac malaria network]. | the malaria control division of the organization for endemic disease control in central africa (oceac) has developed a standardized method to measure the in vivo sensitivity of plasmodium falciparum to antimalarial drugs. between may 1996 and february 1997, a first series of tests using this method was carried out to determine the sensitivity of plasmodium falciparum to chloroquine and amodiaquine in infected school children in four capital cities: yaoundé, brazzaville, malabo, and libreville. a ... | 1997 | 9612776 |
| widespread in vitro resistance to chloroquine of plasmodium falciparum in the congo, 1987. | the drug sensitivity of 184 plasmodium falciparum isolates was studied in vitro in three areas of the congo in january 1987. results show that parasites resistant to chloroquine but not to quinine or mefloquine were prevalent in the three investigated regions, but the drug response pattern varied widely. in brazzaville, after the outburst of chloroquine resistance in 1985, prevalence of chloroquine resistant isolates seemed to have stabilized around 60%. the phenomenon more recently reached the ... | 1991 | 2052858 |
| [prevention and treatment of malaria in expatriates living in black africa. influence of chemoresistance. investigations conducted in brazzaville (congo)]. | the therapeutic, preventive and curative, habits concerning malaria of expatriates living in brazzaville, congo, were investigated on two occasions. in march 1989 and april 1990, a questionnaire was handed out to the pupils of the french school to be filled in by their parents. three quarters of the expatriates are europeans, and 85 percent of these are french. in this country where the chemoresistance of plasmodium falciparum has been established since 1985, chemoprophylaxis was regularly perfo ... | 1991 | 1830144 |
| [clinical presentation of non-pernicious malaria attacks in patients hospitalized in brazzaville (congo) in 1989]. | the clinical manifestations observed in 102 malaria patients (parasitaemia of over 8,000 plasmodium falciparum/mm3) hospitalized in 1989 in brazzaville (congo) were analyzed after ruling out the cases of pernicious malaria. the clinical picture was fever, stomach upset with headache and musculo-articular pain as in classical cases. in children these manifestations were frequently associated with convulsions. diarrhoea was not uncommon in young children. vomiting was frequent in both children and ... | 1991 | 1764754 |
| genetic polymorphism of merozoite surface protein-1 and merozoite surface protein-2 in plasmodium falciparum isolates from brazzaville, republic of congo. | the characterization of malaria parasite populations circulating in an area is part of site characterization, as a basis for evaluating the impact of malaria interventions on genetic diversity, parasite species, and multiplicity of infection. the present study was aimed at analysing genetic diversity of plasmodium falciparum merozoite surface proteins 1 and 2 (msp-1 and msp-2) and to determine the multiplicity of infection in clinical isolates collected from children living in the southern distr ... | 2011 | 21936949 |
| plasmodium falciparum: differential selection of drug resistance alleles in contiguous urban and peri-urban areas of brazzaville, republic of congo. | the african continent is currently experiencing rapid population growth, with rising urbanization increasing the percentage of the population living in large towns and cities. we studied the impact of the degree of urbanization on the population genetics of plasmodium falciparum in urban and peri-urban areas in and around the city of brazzaville, republic of congo. this field setting, which incorporates local health centers situated in areas of varying urbanization, is of interest as it allows t ... | 2011 | 21858115 |
| [malaria in health centres in the southern districts of brazzaville, congo]. | during the surveys on antimalarial drug efficacy carried out from 2003 to 2006, we systematically checked the presence of plasmodium falciparum in patients consulting in two health centres located in the south of brazzaville. the first centre is situated in the urban zone; the second, in the semi rural area. the objective of this survey was to determine the prevalence of malaria-infected patients among the consulting patients and the prevalence of symptomatic patients with acute malaria attacks ... | 2008 | 18956816 |
| therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in brazzaville, congo. | to test the efficacy of sulfadoxine-pyremethamine (sp) monotherapy and establish the prevalence of mutations in dhfr and dhps in brazzaville, congo. | 2007 | 17956498 |
| epidemiology of drug-resistant malaria in republic of congo: using molecular evidence for monitoring antimalarial drug resistance combined with assessment of antimalarial drug use. | in congo, urgent efforts are needed to help with the revision of the national antimalarial drug policy. despite its high resistance level, chloroquine (cq) is still extensively used as the first-line treatment for uncomplicated plasmodium falciparum malaria. the study was conducted in children under 5 years with uncomplicated malaria in pointe-noire and brazzaville, the two largest cities that contain approximately 60% of the population of congo. we investigated by polymerized chain reaction and ... | 2005 | 16185238 |
| in vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in plasmodium falciparum isolates from the republic of congo. | chloroquine (cq) resistance in plasmodium falciparum has been particularly associated with mutations in the pfcrt gene. the present study was carried out in the malaria hyperendemic town of brazzaville (republic of congo, central africa) where cq is still recommended and used as a first-line drug for p. falciparum malaria. we assessed the efficacy of cq in vivo, and the association between pfcrt mutation at codon 76 and treatment outcome in 50 children with uncomplicated malaria. the failure rat ... | 2005 | 16002038 |
| efficacy of sulfadoxine/pyrimethamine in the treatment of uncomplicated plasmodium falciparum malaria in republic of congo. | congo is facing frequent failures of treatment of plasmodium falciparum malaria with chloroquine (cq), which is still recommended and used as a first-line drug. in pointe-noire and brazzaville, the two largest cities that contain approximately 60% of the population of congo, we compared the efficacy of cq versus sulfadoxine/pyrimethamine (sp) for treatment of uncomplicated malaria in children 6-59 months old (mean = 33 months) using the standard world health organization (who) 14-day in vivo tes ... | 2004 | 14993623 |
| [no variation in chloroquine resistance (plasmodium falciparum) from 1986 to 1996 in semi-immune children in brazzaville (congo)]. | a simplified plasmodium falciparum in vivo test was carried out in brazzaville (congo) in april 1996. chloroquine was prescribed at 25 mg/kg for 3 days in asymptomatic brazzavillian school children who presented parasitemia > 800 p. falciparum trophozoïtes and lived in a highly endemic district. a massive decrease of parasitemia was observed on day 2. the percentage of resistance (presence of p. falciparum trophozoïte on day 7 in a thick blood film) was 43.5, 28 and 21 respectively (ic: 95%: 29- ... | 1998 | 9642475 |
| [drug sensitivity of plasmodium falciparum in vivo and in vitro in brazzaville (congo)]. | various projects were launched in 1993 to monitor the chemosensitivity of plasmodium falciparum in congo. resistance of 34 strains in brazzaville to chloroquine, quinine and mefloquine and of 35 to halofantrine was investigated in an in vitro survey using an isotopic micro test. the resistance rates were 61.8, 14.7, 3.0 and 0.0% respectively. thus, the chemoresistance which first appeared in 1990 is confirmed and is stable in the population. this finding was further confirmed by a parallel in vi ... | 1995 | 7894826 |
| [plasmodium falciparum index and level of parasitemia: diagnostic and prognostic value in the congo]. | parasitological data of various malarial studies performed in the congo where plasmodium falciparum malaria is holo-endemic in rural and suburban zones, between 1988 and 1991, were analyzed with the intention of establishing diagnosis and prognosis value of plasmodium falciparum parasitaemia in areas with high perennial transmission. in such an area congolese school-children (6-10 years old) had 88% p. falciparum index, this is the same percentage as that for children hospitalized with a pernici ... | 1995 | 7794061 |
| [plasmodium falciparum malaria and sickle cell gene in the popular republic of congo. i. relationship between parasitemia and sicke cell trait in djoumouna (region of brazzaville) (author's transl)]. | the relationship between sickle cell trait and falciparum malaria was studied in the village of djoumouna, twenty kilometers south west of brazzaville. malaria is characterized by a stable high intensity of transmission on the average one infective mosquito bite by night and by child contrasting with a relatively low malarial infection rate. the prevalence of carriers of an s gene (as) does not change with age: 22.2% for children under 5 years, 22.1% for childrern between 5 and 15 years, and 22. ... | 1981 | 7036841 |
| [plasmodium falciparum and drepanocytic gene in popular republic of congo. i. prevalence of malaria and drepanocytic trait among school children in brazzaville area (author's transl)]. | from 1978 to 1979, 5 surveys, among schoolchildren, were carried out during the rainy season in the neighbourhood of brazzaville (r.p. congo): 3 in pk 45 village (northern part of the capital), 2 in djoumouna village (southern part), and 1 in "talangai" (a suburb of the capital). 868 exams (plasmodic and splenic index fitted with hemoglobin composition [hb aa or hb as]) were done. it appeared that 19,6% of schoolchildren examined were heterozygous sicklers (as). this percentage confirmed the pre ... | 1981 | 7031402 |
| [drug resistance of plasmodium falciparum in congo. i. in vivo study with 10 and 25 mg/kg of chloroquine (235 tests)]. | an evaluation of chloroquine resistance in p. falciparum was conducted in four different areas of the people's republic of the congo during the months of october and november 1985. using the simplified seven day in vivo test protocol, 235 tests were completed in 92 children aged three months to five years seen at the maternal child health clinics (54 children were treated by a single dose at 10 mg/kg and 38 children were treated by the three day dose of 25 mg/kg) and 143 school children aged six ... | 1986 | 3542258 |
| malaria and urbanization in central africa: the example of brazzaville. part iv. parasitological and serological surveys in urban and surrounding rural areas. | five schools were chosen in different districts of brazzaville where the intensity of malaria transmission, determined in a previous study, is representative of the very varied conditions observed in this town in relation to urbanization. the parasitological and serological results found in schoolchildren are analysed according to the level of transmission to which they are exposed, and compared with the results of a longitudinal survey carried out in the rural area of the brazzaville region. in ... | 1987 | 3332057 |
| [studies on malaria in a mosaic forest-savanna zone in central africa, brazzaville region. ii. parasite density]. | malaria is holoendemic in rural areas in the brazzaville region: according to the villages, the crude parasite rate in schoolchildren varies from 81% to 94%. prevalence of classes 3 to 5 parasite densities is high until the age of 15 (41%-63%) and appears to reflect the entomological inoculation rate. parasite rates and densities in young children are lower than expected. this is probably due to the widespread use of antimalarials by this age-group. | 1987 | 3319261 |
| [drug resistance of plasmodium falciparum in the congo. 2. comparative study in vivo of chloroquine and amodiaquine in brazzaville schoolchildren (november 1986)]. | this study was conducted in brazzaville, the capital of congo, for the purpose of assessing the resistance to chloroquine and amodiaquine of plasmodium falciparum. 64 in vivo tests using the who protocol--trial period 7 days after administration over 3 days of a dose of 25 mg/kg (n = 31 for chloroquine, 33 for amodiaquine)--were performed in schoolchildren aged 6 to 7 years, with parasite counts of at least 1,000 trophozoites/mm3. the respective percent resistance was found to be 38.7% (9.7% at ... | 1987 | 3319250 |
| [plasmodium falciparum drug resistance in the congo. evaluation of surveys carried out from 1985 to 1989]. | surveys on drug sensitivity of plasmodium falciparum carried out between 1985 and 1989 included 7-day in vitro tests and in vivo tests. 485 in vivo tests were carried out in eight surveys conducted in brazzaville and in several inland regions. the subjects were congolese children aged between 3 months and 15 years old. they were recruited in hospital, mother-child clinics or at school. the drugs studied were chloroquine, amodiaquine and the sulfadoxine-pyrimethamine combination. 182 strains were ... | 1990 | 2208453 |