Publications

potential impact of seasonal malaria chemoprevention on the acquisition of antibodies against glutamate-rich protein and apical membrane antigen 1 in children living in southern senegal.	seasonal malaria chemoprevention (smc) is defined as the intermittent administration of full treatment courses of an antimalarial drug to children during the peak of malaria transmission season with the aim of preventing malaria-associated mortality and morbidity. smc using sulfadoxine-pyrimethamine (sp) combined with amodiaquine (aq) is a promising strategy to control malaria morbidity in areas of highly seasonal malaria transmission. however, a concern is whether smc can delay the natural acqu ...	2015	26283746
mutations in plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in senegal.	senegal recently (2004) switched to sulfadoxine-pyrimethamine (sp) with amodiaquine as first line therapy for malaria in response to increasing chloroquine resistance. in anticipation of emerging resistance to sp as a result of this change in drug pressure, we set out to define the baseline prevalence of sp-associated mutations in the dhfr and dhps genes in plasmodium falciparum using geographically diverse and longitudinally collected samples. a total of 153 blood samples were analysed from pat ...	2005	16262743