| efficacy of insecticide impregnated bed-nets to control malaria in a rural forested area in southern cameroon. | due to current spreading of chemoresistant strains of plasmodium falciparum malaria control must incorporate vector control programmes. due to well known constraints house sprayings cannot be performed as before. personal protection can be developed and a large scale use of insecticide treated bed-nets appeared to be very useful to reduce man-vector contact in asia, south america and west and east africa. no trial has been done in forest central africa where transmission is permanent. we perform ... | 1992 | 1343714 |
| chloroquine resistant plasmodium falciparum in indigenous residents of cameroon. | thirty-nine percent (36 of 92) of children in limbe, cameroon, treated with chloroquine (10 mg/kg body weight on days 1 and 2, and 5 mg/kg on day 3) for falciparum malaria failed to respond within 7 d of treatment. twenty-two of these children with chloroquine-resistant malaria were successfully treated with fansidar [one-half tablet (250 mg sulfadoxine and 25 mg pyrimethamine) per 10 kg body weight], while the other 14 children were cured with mefloquine (25 mg/kg body weight). in vitro, a comb ... | 1989 | 2694461 |
| molecular epidemiology of malaria in cameroon. xi. geographic distribution of plasmodium falciparum isolates with dihydrofolate reductase gene mutations in southern and central cameroon. | the dna sequence of the dihydrofolate reductase (dhfr) gene, a molecular marker for pyrimethamine resistance, was determined for 178 field isolates of plasmodium falciparum collected along the east-west axis in southern cameroon. the proportion of isolates having the wild-type dhfr allele varied from 48.1% in the east (city of bertoua) to 11.3-15.7% in central provinces (yaounde and eseka) and 0% in the littoral region (port city of douala). isolates with a single asn-108 mutation or double muta ... | 2002 | 12452492 |
| molecular epidemiology of malaria in cameroon. xxii. geographic mapping and distribution of plasmodium falciparum dihydrofolate reductase (dhfr) mutant alleles. | sulfadoxine-pyrimethamine (sp) is still a useful drug to combat chloroquine-resistant plasmodium falciparum malaria in cameroon. because of several disadvantages of the in vivo test and in vitro drug sensitivity assays, molecular assays are an alternative laboratory tool to monitor the evolution of antifolate resistance, especially over the entire country that is characterized by several epidemiologic strata and malaria transmission patterns. in this study, 1,430 blood samples from either sympto ... | 2006 | 16968912 |
| the clinical spectrum of severe malaria in children in the east provincial hospital of bertoua, cameroon. | severe malaria claims 1.5 to 2.7 million lives annually most of which are young children in rural areas in sub-saharan africa. we retrospectively reviewed the files of 387 patients, admitted and treated for severe malaria according to who guidelines, in the bertoua provincial hospital, a peripheral health center in east cameroon from 1st october 1998 to 30h october 2000. our main objective was to study the epidemiological aspects, clinical presentation and outcome. the mean age was 2.7 years (ra ... | 2004 | 17304741 |