| mefloquine resistant malaria in cameroon and correlation with resistance to quinine. | based on the results of in vitro sensitivity of plasmodium falciparum to chloroquine, quinine and mefloquine, and evaluation of drug consumption conducted in 1987-1988 in four areas in the north and south-west of cameroon, two opposite situations were encountered in this country. in northern cameroon where mefloquine resistance is prevalent a close correlation was found between the responses of p. falciparum to mefloquine and to quinine, but not between mefloquine and chloroquine. in the south, ... | 1992 | 1343701 |
| chloroquine sensitivity of plasmodium falciparum in vivo in a savanna town in cameroon. | chloroquine-resistant plasmodium falciparum has been reported in the sahel and forest regions of cameroon since 1985. in vivo response to chloroquine treatment (25 mg/kg) was assessed in 19 patients with malaria in the savanna north-west province. 58% of the cases showed rii resistance to chloroquine. riii resistance was suspected in one patient. only 35% of cases showed complete parasite clearance by day 5 of treatment. chloroquine reduced parasite counts by at least 87% in all patients. chloro ... | 1992 | 1412637 |
| multi-drug resistant falciparum malaria in cameroon in 1987-1988. i. stable figures of prevalence of chloroquine- and quinine-resistant isolates in the original foci. | the status of drug-resistant plasmodium falciparum in cameroon was determined in 1987-1988 in 221 children who were selected for chloroquine and quinine in vitro microtests. resistance to quinine was found in 17% of 72 isolates from the southern part of the country, and in 7% of 87 isolates from the northern part of the country. the effective concentrations of 50% and 90% (ec50 and ec90) differed little from those observed in 1986. in southern cameroon, 38 (51%) of 74 individuals harbored chloro ... | 1992 | 1536378 |
| [epidemiologic study of malaria in the rice-growing regions of yagoua and maga (north cameroon)]. | the results of the malaria investigation carried out in april 1981 in the irrigated regions of the logone valley show that plasmodium falciparum is the only species o. the genus plasmodium to be found there. in terms of parasitaemia in blood, the prevalence of malaria is highest in the 5 to 9 year-old age group, whereas fluorescent antibodies are to be found progressively greater quantities as subjects grow older. from the age of 40, 95% of the inhabitants of the region present circulating antib ... | 1985 | 2863004 |
| patterns of in vitro resistance to chloroquine, quinine, and mefloquine of plasmodium falciparum in cameroon, 1985-1986. | the drug sensitivity of 246 plasmodium falciparum isolates was studied in vitro in five areas of cameroon at the end of 1985. results demonstrate that parasites resistant either to chloroquine, quinine, or mefloquine, or to two of these drugs, were prevalent in four of the areas investigated, but the drug response pattern varies widely from one area to another. the recent explosive emergence of chloroquine resistance in the south of the country, where both prevalences and levels are very high (u ... | 1988 | 3044155 |
| low prevalence of p. falciparum in-vivo resistance to chloroquine in northern cameroon in 1986. | the response to chloroquine of 49 plasmodium falciparum isolates from the northern dry areas of cameroon was assessed by 7 day in-vivo assays. twenty seven patients were treated with the standard 25 mg/kg dose, and 22 received a reduced, but frequently used, 10 mg/kg dose. the results of these in vivo assays are in agreement with in-vitro data showing a low prevalence and a low degree of chloroquine resistance. in contrast with p. falciparum isolates from southern cameroon, no case of rii or rii ... | 1988 | 3057593 |
| [malaria vector control in cameroon: past, present, future. reflections]. | during the fifties, large scale malaria vector control projects based upon house spraying were implemented in southern and northern parts of cameroon in line of malaria eradication concept. in the south, the pilot zone of yaounde gathered about 150,000 inhabitants, in the forest area. first operations started in 1953 but the programme became actually operational in 1956. it was divided in two parts: the western part was treated with ddt, while the eastern one was treated with dieldrin. at the sa ... | 2001 | 16579079 |
| molecular epidemiology of malaria in cameroon. xxii. geographic mapping and distribution of plasmodium falciparum dihydrofolate reductase (dhfr) mutant alleles. | sulfadoxine-pyrimethamine (sp) is still a useful drug to combat chloroquine-resistant plasmodium falciparum malaria in cameroon. because of several disadvantages of the in vivo test and in vitro drug sensitivity assays, molecular assays are an alternative laboratory tool to monitor the evolution of antifolate resistance, especially over the entire country that is characterized by several epidemiologic strata and malaria transmission patterns. in this study, 1,430 blood samples from either sympto ... | 2006 | 16968912 |
| efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated plasmodium falciparum malaria in children in cameroon at the time of policy change to artemisinin-based combination therapy. | the efficacy of amodiaquine (aq), sulphadoxine-pyrimethamine (sp) and the combination of sp+aq in the treatment of cameroonian children with clinical malaria was investigated. the prevalence of molecular markers for resistance to these drugs was studied to set the baseline for surveillance of their evolution with time. | 2010 | 20105282 |
| role of anopheles (cellia) rufipes (gough, 1910) and other local anophelines in human malaria transmission in the northern savannah of cameroon: a cross-sectional survey. | as part of a study to determine the impact of insecticide resistance on the effectiveness of long-lasting insecticide treated nets (llins) in the north of cameroon, the unexpectedly high density and anthropophilic behaviour of anopheles rufipes lead us to investigate this species bionomics and role in human malaria parasite transmission. | 2017 | 28077167 |