Publications

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malaria in china and the equatorial pacific area from 1937 to 1943. 19734611054
chloroquine-resistant malaria in singapore. 19694906993
the importance of chloroquine resistant malaria in singapore in 1969. 19704918491
chloroquine-resistant falciparum malaria among british service personnel in west malaysia and singapore. 19714934534
chloroquine resistant malaria in children from a chinese albino family in pulau tekong. 19714937591
malaria outbreak at pulau tekong in singapore. 19714943953
imported malaria in a singapore hospital: clinical presentation and outcome.to evaluate the clinical presentation and outcome of imported malaria.199910460924
a comparison of antigen dipstick assays with polymerase chain reaction (pcr) technique and blood film examination in the rapid diagnosis of malaria.early diagnosis of malaria for military personnel training in the field is crucial in providing proper treatment for the infected and in taking appropriate preventive measures for the non-infected. present preliminary diagnosis of malaria in the field depends on the clinical symptoms of the patients and there is a need for rapid diagnosis of malaria in the field. the presence of drug-resistant strains of the plasmodium species in the region also increases the urgency of finding a quick and sensi ...199910561760
re-starting malaria research at the novartis institute for tropical diseases (nitd). 200717939125
a large cluster of imported plasmodium falciparum malaria among nigerian expatriate students.singapore reported the elimination of malaria in 1982, but this country remains vulnerable to imported malaria. we describe a large cluster of 16 cases of imported plasmodium falciparum malaria in visiting nigerian students. more than half were asymptomatic and diagnosed only on screening. although early diagnosis and treatment of patients averted local transmission of disease, our report illustrates the vulnerability of malaria-free countries to the introduction of malaria in this age of increa ...200717978088
lagunamides a and b: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium lyngbya majuscula.lagunamides a (1) and b (2) are new cyclic depsipeptides isolated from the marine cyanobacterium lyngbya majuscula obtained from pulau hantu besar, singapore. the planar structural characterization of these molecules was achieved by extensive spectroscopic analysis, including 2d nmr experiments. in addition to marfey's method and (3)j(h-h) coupling constant values, a modified method based on mosher's reagents and analysis using lc-ms was deployed for the determination of the absolute configurati ...201020936843
an integrated lab-on-chip for rapid identification and simultaneous differentiation of tropical pathogens.tropical pathogens often cause febrile illnesses in humans and are responsible for considerable morbidity and mortality. the similarities in clinical symptoms provoked by these pathogens make diagnosis difficult. thus, early, rapid and accurate diagnosis will be crucial in patient management and in the control of these diseases. in this study, a microfluidic lab-on-chip integrating multiplex molecular amplification and dna microarray hybridization was developed for simultaneous detection and spe ...201425078474
plasmodium knowlesi infection: a diagnostic challenge.plasmodium knowlesi malaria is an uncommon, but highly prevalent parasitic infection in parts of malaysia. this is the case of a 14-year-old singaporean boy presenting to our emergency department with an 11-day history of fever following a school trip to malaysia. hepatosplenomegaly was the only clinical finding; laboratory tests showed thrombocytopaenia, lymphopaenia, mild anaemia and liver transaminitis. specific malaria antigen tests were negative, but the peripheral blood film showed plasmod ...201323608876
malaria in a tertiary hospital in singapore--clinical presentation, treatment and outcome: an eleven year retrospective review.malaria remains a global health threat and poses significant health risks even in non-endemic regions like singapore.201525467088
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