| insecticide-treated bednets for the prevention of plasmodium falciparum malaria in cambodia: a cluster-randomized trial. | to validate and quantify the impact of insecticide-treated bednets (itn) on malaria morbidity and mortality in cambodia. | 2006 | 16903880 |
| sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in rattanakiri province, cambodia: implication for malaria elimination. | malaria microscopy and rapid diagnostic tests are insensitive for very low-density parasitaemia. this insensitivity may lead to missed asymptomatic sub-microscopic parasitaemia, a potential reservoir for infection. similarly, mixed infections and interactions between plasmodium species may be missed. the objectives were first to develop a rapid and sensitive pcr-based diagnostic method to detect low parasitaemia and mixed infections, and then to investigate the epidemiological importance of sub- ... | 2010 | 20409349 |
| spatial clustering and risk factors of malaria infections in ratanakiri province, cambodia. | malaria incidence worldwide has steadily declined over the past decades. consequently, increasingly more countries will proceed from control to elimination. the malaria distribution in low incidence settings appears patchy, and local transmission hotspots are a continuous source of infection. in this study, species-specific clusters and associated risk factors were identified based on malaria prevalence data collected in the north-east of cambodia. in addition, plasmodium falciparum genetic dive ... | 2014 | 25269827 |
| geographical patterns of malaria transmission based on serological markers for falciparum and vivax malaria in ratanakiri, cambodia. | malaria transmission is highly heterogeneous, especially in low endemic countries, such as cambodia. this results in geographical clusters of residual transmission in the dry, low transmission season, which can fuel the transmission to wider areas or populations during the wet season. a better understanding of spatial clustering of malaria can lead to a more efficient, targeted strategy to reduce malaria transmission. this study aims to evaluate the potential of the use of serological markers to ... | 2016 | 27756395 |
| ex vivo susceptibility of plasmodium falciparum to antimalarial drugs in western, northern, and eastern cambodia, 2011-2012: association with molecular markers. | in 2008, dihydroartemisinin (dha)-piperaquine (ppq) became the first-line treatment for uncomplicated plasmodium falciparum malaria in western cambodia. recent reports of increased treatment failure rates after dha-ppq therapy in this region suggest that parasite resistance to dha, ppq, or both is now adversely affecting treatment. while artemisinin (art) resistance is established in western cambodia, there is no evidence of ppq resistance. to monitor for resistance to ppq and other antimalarial ... | 2013 | 23939897 |
| efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated plasmodium falciparum and plasmodium vivax in cambodia, 2008 to 2010. | we describe here the results of antimalarial therapeutic efficacy studies conducted in cambodia from 2008 to 2010. a total of 15 studies in four sentinel sites were conducted using dihydroartemisinin-piperaquine (dp) for the treatment of plasmodium falciparum infection and chloroquine (cq) and dp for the treatment of p. vivax infection. all studies were performed according to the standard world health organization protocol for the assessment of antimalarial treatment efficacy. among the studies ... | 2013 | 23208711 |
| reduced artemisinin susceptibility of plasmodium falciparum ring stages in western cambodia. | the declining efficacy of artemisinin derivatives against plasmodium falciparum in western cambodia is a major concern. the knowledge gap in the understanding of the mechanisms involved hampers designing monitoring tools. here, we culture-adapted 20 isolates from pailin and ratanakiri (areas of artemisinin resistance and susceptibility in western and eastern cambodia, respectively) and studied their in vitro response to dihydroartemisinin. no significant difference between the two sets of isolat ... | 2013 | 23208708 |