| pcr-amplification, sequencing, and comparison of the var/pfemp-1 gene from the blood of patients with falciparum malaria in the philippines. | the adhesion of plasmodium falciparum-infected erythrocytes to vascular endothelium and to uninfected red blood cells (rbcs) plays a key role in the pathology of severe malaria. adhesion is known to be mediated in part by the antigenically-variant erythrocyte membrane protein-1 (pfemp-1), which is encoded by the var-gene family of p. falciparum. it has recently been reported that in vitro a single parasite simultaneously transcribes multiple var-genes but that, through a developmentally regulate ... | 2002 | 12971466 |
| in vitro susceptibility of plasmodium falciparum isolates to chloroquine and mefloquine in southeastern mindanao island, the philippines. | although the presence of multi-drug-resistant falciparum malaria has been reported in the philippines, the distribution of drug-resistant malaria parasites has not yet been determined in mindanao island. in vitro susceptibility of p. falciparum to both chloroquine and mefloquine was assessed to forecast the spread of drug-resistant parasites in various foci in southeastern mindanao island. of the 33 isolates of p. falciparum successfully tested, 10 (30%) were susceptible, 12 (36%) showed decreas ... | 2003 | 15115125 |
| field evaluation of malaria rapid diagnostic tests for the diagnosis of p. falciparum and non-p. falciparum infections. | the objective of this study was to evaluate various malaria rapid diagnostic tests as a tool in the detection of p. falciparum and non-p. falciparum infections in field conditions. four field surveys were conducted in malaria-endemic areas of palawan and davao del norte, philippines to validate the various rapid diagnostic tests, namely diamed optimal 48 (diamed ag, switzerland), parahit f (span diagnostics, india), orchid optimal, and paracheck pf (both from orchid biomedical systems, india). t ... | 2005 | 16124416 |
| phylogenetic relationship of plasmodium falciparum populations in the philippines. | malaria is one of the major infectious diseases in the philippines. it is being targeted for control through sustained early diagnosis, treatment and mosquito control. it is in this light that understanding the genetic background of the parasite population is important not only for basic biology of the organism but also for epidemiology and control of the disease. in the present study, molecular phylogenetic relationships of the 3 plasmodium falciparum populations in the philippines with the oth ... | 2008 | 18564702 |
| genetic diversity and population structure of plasmodium falciparum in the philippines. | in the philippines, malaria morbidity and mortality have decreased since the 1990s by effective malaria control. several epidemiological surveys have been performed in the country, but the characteristics of the plasmodium falciparum populations are not yet fully understood. in this study, the genetic structure of p. falciparum populations in the philippines was examined. | 2009 | 19422722 |