| investigation of malaria sporozoites by immunoradiometric assay. | two-site immunoradiometric assay (irma) (zavala et al., 1982) using monoclonal antibodies to p. falciparum and p. vivax was applied to detect sporozoites in laboratory-maintained an. dirus and also mosquitoes collected from endemic areas of malaria in thailand. study in p. falciparum infected mosquitoes revealed that the circumsporozoite (cs) antigen was first found in the abdominal portion on day 10 post-infection, while it could be observed in the salivary glands from day 15 onwards. the head- ... | 1988 | 3043705 |
| susceptibility of plasmodium falciparum to five drugs: an in vitro study of isolates mainly from thailand. | this paper describes the results of testing the susceptibility of 60 isolates of the human malaria parasite plasmodium falciparum from thailand, and single isolates from five other countries, to five drugs: chloroquine, pyrimethamine, quinine, mefloquine and amodiaquine. the thai isolates were obtained from patients in three different regions of the country (chantaburi, songkhla and mae sod), and were first grown in culture by the trager-jensen candle-jar technique. samples were then exposed to ... | 1983 | 6346591 |
| artemether or artesunate followed by mefloquine as a possible treatment for multidrug resistant falciparum malaria. | plasmodium falciparum in south-east asia is highly resistant to chloroquine and sulfadoxine-pyrimethamine. mefloquine used to be the chemosuppressant drug of choice in areas with chloroquine resistance. however, sensitivity to this drug has recently decreased in thailand, cambodia and myanmar, and there is no suitable single alternative drug. we therefore investigated possible alternative combination therapies for multidrug resistant falciparum malaria. 120 male thai patients at makarm malaria c ... | 1996 | 8882193 |
| plasmodium falciparum and p. vivax circumsporozoite proteins in anophelines (diptera: culicidae) collected in eastern thailand. | in total, 414 anophelines, consisting of anopheles karwari (james), an. splendidus koidzumi, an. dirus peyton & harrison, and an. barbirostris van der wulp were collected in 2 provinces in eastern thailand and tested by enzyme-linked immunosorbent assay for the presence of circumsporozoite proteins. plasmodium vivax cs protein was detected in 3.4% (2/54) of an. karwari and 4.8% (2/42) of an. barbirostris specimens. both p. vivax phenotypes, pv247 and pv210, were found in an. karwari, whereas onl ... | 1996 | 8961653 |
| a comparative study of artesunate and artemether in combination with mefloquine on multidrug resistant falciparum malaria in eastern thailand. | plasmodium falciparum in thailand is highly resistant to chloroquine, sulfadoxine-pyrimethamine and there is increasing resistance to quinine and mefloquine. the use of qinghaosu derivatives alone or in combination with mefloquine has been shown successfully effective against multidrug resistant p. falciparum in many clinical trials. however their applications with ambulatory treatment should be assessed. 394 uncomplicated falciparum malaria cases studied at trat and chanthaburi malaria clinics, ... | 1997 | 9561593 |
| two doses of artemether/mefloquine or artesunate/mefloquine combination for multidrug resistant falciparum malaria. | plasmodium falciparum in southeast asia is highly resistant to chloroquine, sulfadoxine/ pyrimethamine, quinine and even mefloquine. the use of two doses of short course artemether/mefloquine combination has been shown to be effective in a recent study. in the present study, we have assessed the efficacy of short course treatment with artesunate/mefloquine, in comparison with artemether/mefloquine in patients with multidrug resistant falciparum malaria. ninety-nine thai male patients who sought ... | 1997 | 9656393 |
| six-years monitoring the efficacy of the combination of artesunate and mefloquine for the treatment of uncomplicated falciparum malaria. | plasmodium falciparum in thailand is multi-drug resistant. in a previous study it was shown that artesunate and mefloquine were effective, as follow up, we monitored the efficacy of this regimen for six years. during 1997-2002, 516 adult male volunteer patients in chanthaburi province were enrolled (50 patients in the first year, 400 patients in 1998-2001 and 66 patients in 2002). the symptom complex and parasite count (thick blood film) were monitored on days 0, 1, 2, 7, 14, 21, 28, 35 and 42. ... | 2003 | 15115124 |
| molecular epidemiology of drug resistance markers of plasmodium falciparum malaria in thailand. | to determine differences in the distribution of drug resistance mutations in the plasmodium falciparum chloroquine resistance transporter (pfcrt) and p. falciparum multi-drug resistance 1 (pfmdr1) genes of p. falciparum isolates in thailand, a study was conducted using polymerase chain reaction-restriction fragment length polymorphism to detect mutations in p. falciparum isolates obtained from three areas with different levels of in vivo mefloquine (mq) resistance. all isolates carried mutant al ... | 2005 | 16045457 |
| saccharosporones a, b and c, cytotoxic antimalarial angucyclinones from saccharopolyspora sp. bcc 21906. | three new angucyclinones, saccharosporones a, b and c, together with (+)-ochromycinone, (+)-rubiginone b2, tetrangulol methyl ether and fujianmycin a, were obtained from fermentation of the terrestrial actinomycete of the genus saccharopolyspora bcc 21906 isolated from a soil collected in chanthaburi province, thailand. structures of the new compounds and their relative configurations were assigned by nmr spectral data interpretation. saccharosporones a and b exhibited antimalarial activity agai ... | 2013 | 23549355 |
| characteristics and malaria prevalence of migrant populations in malaria-endemic areas along the thai-cambodian border. | the rise of artemisinin resistant plasmodium falciparum along the thai-cambodian border is an urgent public health threat. we conducted an employer-based survey of migrant workers in two provinces in thailand along the thai-cambodian border to explore socio-economic conditions, bednet ownership, and parasite prevalence among migrant workers. five thousand three hundred seventy-one migrant workers were enrolled in this study; 56.9% were male. cambodians comprised 69.0%, migrants from myanmar comp ... | 2012 | 23082578 |