| drug resistant malaria, with special reference to thailand. | drug resistance of malaria parasites is a major problem confronting efforts to treat and control malaria. starting with chloroquine, the emergence of resistance to other drugs has led to multi-drug resistance patterns that pose increasing threats for the future. this report reviews work carried out over the past decades at the hospital for tropical diseases, bangkok, which monitors patients from many areas, including the thai-cambodian border, which harbors the world's most severe multi-drug res ... | 1992 | 1298068 |
| comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria. | plasmodium falciparum malaria in thailand is highly resistant to available antimalarials, and alternative drugs are needed urgently. artemether is effective against falciparum malaria but associated with a high recrudescence rate. the proper dosage regimen remains to be defined. we have done a clinical trial comparing mefloquine 1250 mg in divided doses with oral artemether at 700 mg total dose given over 5 days in acute uncomplicated falciparum malaria. 46 patients, admitted to the bangkok hosp ... | 1992 | 1359318 |
| the future outlook of antimalarial drugs and recent work on the treatment of malaria. | with the emergence of multidrug-resistant falciparum malaria, new drugs and drugs in combination are urgently needed. new antimalarial drugs investigated at the hospital for tropical diseases of the faculty of tropical medicine at mahidol university in bangkok, thailand in recent years for treatment of uncomplicated and severe falciparum malaria are as follows: atovaquone, and artemisinin derivatives (artesunate, artemether, arteether, and dihydroartemisinin) combined with other antimalarials.ma ... | 2002 | 12234533 |
| efficacy of db289 in thai patients with plasmodium vivax or acute, uncomplicated plasmodium falciparum infections. | db289 is the orally active prodrug of the diamidine db75, which was developed for the treatment of human african trypanosomiasis. | 2005 | 15962227 |
| can treatment of p. vivax lead to a unexpected appearance of falciparum malaria? | of 994 patients admitted to the bangkok hospital for tropical diseases for p. vivax malaria, 104 (10.5%) experienced appearance of plasmodiumfalciparum following drug treatment for p. vivax . in all patients, p. falciparum parasites were not found by microscopic examination upon admission. the mean time for p. falciparum appearance was 12.6 days after the commencement of chloroquine treatment. patients experiencing appearance of p. falciparum had significantly lower hematocrit, and greater initi ... | 2001 | 11485096 |
| serological evaluation of malaria patients in thailand: antibody response against electrophoresed antigenic polypeptides of plasmodium falciparum. | it was reported that a 47kda antigenic polypeptide of plasmodium falciparum had been strongly presented by the sera from 1) imported japanese malaria patients with severe symptoms and 2) symptomatic and parasitemic inhabitants in endemic areas in the sudan, malaysia and the philippines. in the present study, we observed the reactivity of the sera from falciparum malaria patients who had been hospitalized in the bangkok hospital for tropical diseases, faculty of tropical medicine, mahidol univers ... | 1998 | 9886125 |
| quinine-tetracycline for multidrug resistant falciparum malaria. | plasmodium falciparum in southeast asia is highly resistant to chloroquine and sulfadoxine/ pyrimethamine. quinine-tetracycline has been used as a second line treatment for uncomplicated falciparum malaria, but duration of treatment varies from place to place. the 7-days course of this combination has been shown to be very effective. however, due to the cinchonism adverse effects, the patient compliance has not been satisfactory. we have evaluated the efficacy of a 7-days course of tetracycline ... | 1996 | 9031393 |
| comparison of oral artesunate and quinine plus tetracycline in acute uncomplicated falciparum malaria. | in thailand plasmodium falciparum malaria is highly resistant to available antimalarials. investigations on the efficacy of existing antimalarials and of alternative drugs are urgently needed. artesunate has been shown to be effective against falciparum malaria, but is associated with a high recrudescence rate. we have carried out a comparative clinical trial of the standard regimen of quinine + tetracycline versus oral artesunate at a 700-mg total dose given over 5 days to patients with acute u ... | 1994 | 8205643 |
| elevated serum levels of il-10 and ifn-gamma in patients with acute plasmodium falciparum malaria. | serum levels of interleukin-10 (il-10) and interferon-gamma (ifn-gamma) were determined in 37 patients with acute plasmodium falciparum malaria in bangkok, thailand. serum levels of il-10 and ifn-gamma were markedly elevated in patients with malaria prior to treatment (717 +/- 260 pg/ml versus 2.2 +/- 1.3 pg/ml in healthy controls; 123 +/- 71 pg/ml versus 29 +/- 9 pg/ml, respectively; mean +/- sd). serum levels of ifn-gamma and il-10 dropped significantly during treatment and were normal 14 and ... | 1995 | 7994921 |
| pharmacokinetic study of mefloquine in thai children aged 5-12 years suffering from uncomplicated falciparum malaria treated with msp or msp plus primaquine. | a triple combination of mefloquine, sulfadoxine and pyrimethamine (msp) was used with primaquine for the radical treatment of falciparum malaria in thailand. primaquine was reported to inhibit hepatic microsomal enzymes and drug metabolism in animal and man. 23 children hospitalized in the hospital for tropical diseases, faculty of tropical medicine, bangkok, thailand, were randomly allocated into two groups, group i received msp equivalent to 20 mg base of mefloquine/kg body weight and group ii ... | 1994 | 7957448 |
| cutaneous delayed-type hypersensitivity responsiveness in patients during and after plasmodium falciparum and plasmodium vivax infections. | to assess cellular immune function in malaria, 61 patients admitted to the bangkok hospital for tropical diseases with plasmodium falciparum (pf) or plasmodium vivax malaria were examined with the multitest cmi system (merieux institute, florida) to evaluate delayed-type hypersensitivity (dth) during and after acute disease over 4 weeks. all patients demonstrated significantly decreased responsiveness to seven commonly encountered recall antigens. this deficit was most severe immediately upon ad ... | 1995 | 7554489 |
| a longitudinal study of seroreactivities to a major blood stage antigen (pf155/resa) of the malaria parasite plasmodium falciparum in an endemic area of thailand. | we have performed a longitudinal study of the formation of antibodies to plasmodium falciparum in an area of thailand where malaria transmission is moderate and seasonal. the study population comprised 118 subjects living in two villages 230 km southeast of bangkok. all subjects included in this study were seropositive for antibodies to the blood stages of p. falciparum but only approximately 80% had antibodies to the blood stage antigen pf155/resa when assayed by erythrocyte membrane immunofluo ... | 1994 | 7529944 |
| sulfadoxine-pyrimethamine resistant falciparum malaria in thai children. | sixty-eight children with uncomplicated falciparum malaria admitted to the hospital for tropical diseases in bangkok during april-december 1980 were randomly divided into 3 groups and given 3 regimens. group 1 of 27 cases were treated with a single dose of sulfadoxine 20 mg per kg body wt and pyrimethamine 1.0 mg per kg body wt. two cases (7.4%) were cured (s) while 4 cases (14.8%) showed ri failure, 17 cases (63.0%) rii failure and 4 cases (14.8) riii failure. in group 2, 18 cases were treated ... | 1981 | 7043751 |
| a phase-iii clinical trial of mefloquine in children with chloroquine-resistant falciparum malaria in thailand. | mefloquine is a highly effective drug for the treatment of falciparum malaria among adults, but studies of its effects on children are lacking. an open, noncomparative trial of mefloquine was therefore carried out among 84 children aged 5-12 years who were patients at the hospital for tropical diseases, mahidol university, bangkok, thailand. the drug was administered as a single dose of 18-29 mg base per kg body weight. eighty-two of the 84 children completed a 42-day period of post-treatment ob ... | 1987 | 3301042 |
| plasmodicidal effect of desferrioxamine b in human vivax or falciparum malaria from thailand. | desferrioxamine b (dfo, desferal), an iron chelator, was earlier shown to be active against plasmodium falciparum in vitro and in vivo. the present open pilot study served to assess its clinical tolerability and efficacy in human malaria under hospital conditions. continuous intravenous dfo was administered to 28 thai males at a dose of 100 mg/kg over 24 h for 3 consecutive days. no other antimalarial therapy was administered unless recrudescence had occurred. the first 14 patients had symptomat ... | 1992 | 1359761 |
| in vivo and in vitro studies of chloroquine-resistant malaria in thailand. | fourteen patients infected with falciparum malaria admitted to the hospital for tropical diseases in bangkok, faculty of tropical medicine, mahidol university, were studied. in vivo and in vitro methods were used to compare the effects of chloroquine on plasmodium falciparum. the results showed that ri in vivo corresponded to samples containing chloroquine base 2.5-3.5 millimicromoles per ml of blood in vitro and rii in vivo corresponded to samples with chloroquine base of 4.0 millimicromoles pe ... | 1977 | 339855 |
| dose ranging studies of new artemisinin-piperaquine fixed combinations compared to standard regimens of artemisisnin combination therapies for acute uncomplicated falciparum malaria. | to determine the optimum dose of artemisinin-piperaquine combination therapies for acute uncomplicated plasmodium falciparum malaria, we examined 7 candidate regimens in 411 patients admitted to the bangkok hospital for tropical diseases. the studies were performed from may 2005 to october 2005 and november 2005 to june 2006. we compared 3-day courses of artesunate-mefloquine, artemether-lumefantrine (coartem) and of dihydroartemisinin-piperaquine (artekin) as reference antimalarial treatments, ... | 2007 | 18613536 |
| travelers' malaria among foreigners at the hospital for tropical diseases, bangkok, thailand - a 6-year review (2000-2005). | we retrospectively examined the charts of travelers admitted to the hospital for tropical diseases, bangkok, thailand, with malaria during the years 2000-2005. twenty-one cases of malaria were identified, of which 12 (57%) were plasmodium vivax infections and 9 (43%) were p. falciparum infections. there was one mixed case with vivax and falciparum infection. only 1 p. falciparum case had complications. all cases were successfully treated with standard antimalarial drugs. only 3 of the 21 cases w ... | 2006 | 16969060 |
| evaluation of the kat-quick malaria rapid test for rapid diagnosis of falciparum malaria in thailand. | in recent years, several rapid diagnostic tests for falciparum malaria have been developed. kat test results were compared with microscopy on 90 consecutive patients hospitalized at the hospital for tropical diseases, bangkok, thailand. fifty-one patients had p. falciparum infections while 49 had malaria due to other plasmodium species. for a geometric mean +/-sd (min;max;range) parasitemia of 11,481 +/- 5.0 (88;713,838;713,750), the sensitivity of the kat test was 96% (95% ci = 86-99.5), the sp ... | 2004 | 15272742 |
| frequency of early rising parasitemia in falciparum malaria treated with artemisinin derivatives. | to define the frequency of the early rising of parasitemia in falciparum malaria patients treated with artemisinin derivatives, a retrospective chart review of 497 patients admitted to the hospital for tropical diseases, bangkok in 1996 was carried out. early rising parasitemia, defined as an increase in the parasite count over the baseline pretreatment level during the first 24 hours of treatment, was found in 59/229 episodes (25.8%) of uncomplicated, and 111/268 episodes (41.3%) of complicated ... | 2001 | 11485095 |
| a comparative clinical trial of two different regimens of artemether plus mefloquine in multidrug resistant falciparum malaria. | plasmodium falciparum in thailand is highly resistant to available antimalarial drugs. artemether, a derivative of artemisinin, is a promising compound currently used to cope with this situation but the course of treatment has to be at least 5 d. an effective short treatment course of this drug is possible when used in combination with mefloquine. we now report a trial of different regimens of the combination artemether/mefloquine. fifty-seven male thai patients, admitted to the bangkok hospital ... | 1995 | 7660440 |