| evaluation of an in vitro assay system for drug susceptibility of field isolates of plasmodium falciparum from southern thailand. | an in vitro assay system has been developed to evaluate the susceptibility of field isolates of plasmodium falciparum to standard and new antimalarials. the assay used drugs which were serially diluted in the field and determined effective drug concentrations by quantitating schizont maturation after a variable incubation period. based on the id50 values, a series of isolates from yala in southern thailand were shown to be resistant to chloroquine (187 nm) but only moderately resistant to amodia ... | 1988 | 3277459 |
| genetic diversity and population structure of plasmodium falciparum in thailand, a low transmission country. | the population structure of the causative agents of human malaria, plasmodium sp., including the most serious agent plasmodium falciparum, depends on the local epidemiological and demographic situations, such as the incidence of infected people, the vector transmission intensity and migration of inhabitants (i.e. exchange between sites). analysing the structure of p. falciparum populations at a large scale, such as continents, or with markers that are subject to non-neutral selection, can lead t ... | 2009 | 19602241 |
| tracking origins and spread of sulfadoxine-resistant plasmodium falciparum dhps alleles in thailand. | the emergence and spread of drug-resistant plasmodium falciparum have been a major impediment for the control of malaria worldwide. earlier studies have shown that similar to chloroquine (cq) resistance, high levels of pyrimethamine resistance in p. falciparum originated independently 4 to 5 times globally, including one origin at the thailand-cambodia border. in this study we describe the origins and spread of sulfadoxine-resistance-conferring dihydropteroate synthase (dhps) alleles in thailand ... | 2010 | 20956597 |